Phase I - Functionalization of compounds (Homo sapiens)

From WikiPathways

Jump to: navigation, search
32, 126, 16976, 8940, 9414, 935, 11, 54, 591641053, 13, 49461623, 9536, 1347425, 91, 123, 1389422, 117113452771, 158107, 1481506015618, 56865351, 8224, 142119, 157154, 167100, 129, 1609034, 15710411375, 1418556112, 43, 1366244, 165, 16638, 4111157, 108, 139102, 17058, 11614026, 109, 125, 13233, 124, 15597, 133, 16312868, 1068147, 14367112117, 131, 1593, 1310, 21, 39, 48, 85...5638, 4120, 6419, 872917, 11822, 34, 1574, 79, 13713515, 50, 72, 73, 98...96, 16812778, 1521, 65, 80, 846, 637311018869, 99119, 15737, 523538, 4177, 16166, 146301301622870, 121147nucleoplasmendoplasmic reticulum lumenperoxisomal matrixmitochondrial matrixtransport vesicle membranelipid dropletmitochondrial intermembrane spacenucleoplasmcytosolNADPHH2ONAD+CYP11A1:FDXR:FDX1,FDX1L (red.)H2OO2H+CYP2C8 CYP2C9 CYP3A43H2OCH2ONADP+CYP2E1 Cytochrome P450(CYP4F2/4F3 based)19OH-PGH2CYP3A7 NR1H4 HPTXLCYP3A43 NADP+H2OALDH3A1CYP2W1 NADPH5HIALDParaxanthineCYP2A6 C6H6CYP4F11 6BHTO2CCl4CYP27B1(?-508)COUMH2ODDCXCTLADSQCYP2B6 CYP2R1ARAPGI2CYP2A13 CYP4F22 Fe2+ H2OH2OCYP4A22 CYP2S1 DCA VCCYP11A1 NADPHPTGIS H2O2O2NADP+H2OCYP11A1:FDXR:FDX1,FDX1L (ox.)Cytochrome P450(CYP4B1 based)H2OCYP2C19 FMO3 H2OCYP4A22 O2NADP+H+PTGS1 dimerCYP2S1 Cytochrome P450(CYP2C19 based)H+CYP4V2CYP2A6 O2CYP2C8 8,9-EET NADP+H+NADP+FAD LNSOLCYP11A1 NASPMH2OCYP2A7 Cu2+ PTCNDOXOL2CEONADP+O2CYP19A1CH3CHOAc-CoAFe3+ NADPHO2CYP2B6 H2OISCALCYP2D6 H2OCytochrome P450(CYP2W1 based)H+H+FMO3:FADLTB4CYP11B1 20OH-TrXA3CYP4A22 H+NADPHPORH+NADP+CYP21A2NH3EPHX1TMAOPhenytoinFDX1 CYP2C9 NADPHAFXBOH2ONADP+NADP+CYP2S1 AMPH+Cytochrome P450(CYP11B1 based)LCHA O2CYP2E1 CYP2A6 NADP+H2OSPNNADP+CORSTADH1A CYP2F1 4CHOL7a,24(S)DONENADP+NADPHCYP24A1CYP8B1 H2ONADPHSPMALDH1A1 tetramerO2CYP2J2 NOHA1,25(OH)2DH+H2OH2OH2O2NADP+ALDH2 O2CYP2A13 H2ONAD+4CHOL7a,27DONEH2OH+CYP4B1 Mo-MPT NADP+H+18OH-ARAHTOLBH+CYP4F22 FMO2:FAD:Mg2+Cytochrome P450(CYP7A1 based)NADPHCYP3A43 H2O12OH-DDCXH2OO2H2OH+CoA-SH27OH-CHOLO2H2OO2MINDLTB4NADPHNAD+H2OPhenylacetaldehydeCYP2C18 NADPHH2OCYP4B1 NADPHPGG2H2OO2ACV11DCORSTH2OTBXAS1EtOADH4 HBrADH6 NADP+HPHTNADP+H2O5,6-EET NHABPO2CYP2B6 NADPHO2ABPHBZALNADPH11DCORSTCYP4A22 H+O2HCOOHPGH2CYP4F12 CYP2U1NH3CYP4F22 H2OCYP2C8 NADPHO2Cytochrome P450(CYP2D6 based)CPMH+NADPHCYP2B6 O2NADPHLPAMNADPHH+CYP4A11 O2NADPHH+H+CYP4F22CYP4F11 H2OCYP4F2 25OH-CHOLCYP2C9 CYP2F1 ADH1B CYP2F1 CYP4A11 CYP4 H2OL-ValCytochrome P450(CYP2A3 based)H+EtOHCYP3A5 O2(2Fe-2S)2+ 19HETEAHR NADP+Cytochrome P450(CYP3A5 based)TMAH+quinoneNADPH17aHPREGHCOUH+H2OH2OCYP2F1 TrXA3NADP+CH3COO-H2ONADP+Cytochrome P450(CYP4A11 based)CH3CHOO2AOC1 Zn2+ PTGIS NADPHH+NADPHPOMC(138-176)O2CYP2E1 CYP2A13 CYP2C19 H+EST17bCYP2C19 FDX1 COCN12-HETEO2CYP3A4 4HPAANADPHS-HMGSHH2OH+NADP+NADPHCYP2F1 ADH1C CYP2C9 CYP4F2 TrichloromethylradicalATPCu2+ H+H2OADH5 H+MARC2 CTLH+DEXTMAOA PREGCytochrome P450(CYP4F12 based)(2Fe-2S)(1+) NADPHNADP+CYP26C1NADPHH+MTZNADPHCYP4F11 CYP4F3 NADHH2O2TYRFAD H+CYP4F3 FMO1:FADH2OCHOL3b,7a,25TRIOLNADPHTAMDEXMO2CYP4F8 CYP2C19 NADP+O2CYP2E1 diketoneO2Cytochrome P450(CYP3A7 based)NADP+H2ONADPHMAOB INDOLH2O2NADPHBaP4,5OCYP39A1CoA-SHMAOA:FADCYP2S1 CYP2A7 H+NADP+CYP2C19 H+CHOLO2CYP3A5 BaP4,5-DHDO2O2H2OCYP2F1 ACSS2CYP2W1 OxindoleCYP26B1 Ca2+ H2O2CYP2B6 NADPHH+H2O2CYP4F3 NADP+CYP2C18 CHOLH2OCYP2J2 H2OSPMH2OBEGH+Zn2+ CYP27A1ADH5:2xZn2+ dimerALDH1A1 H+PREGN-demethylatedloperamideCYP2C19 CYP2A7 NADP+O2CYP2S1 MLTNADP+Cytochrome P450(CYP4F11 based)H+NADPHCYP2C19 cis-EETH2OCYP2A13 6BHTP4TFACH+CYP4F2 H2OCYP7A1 H+H2OCytochrome P450(CYP2C18 based)NQO2:FAD dimerCYP1B1heme b NADP+CYP8B1 NADHCYP4F8 CYP26A1 CYP2F1 H+CES2 CYP2F1 CORTNADP+NADP+NADP+CYP4F3 CYP2D6 TESO2CYP17A1NADPHCES1 trimer, CES2I4AHCYP4A11 FDX1L NAD+NADP+NADP+NADP+CYP2A7 CYP2C8 NADPH20a,22b-DHCHOLNASPNNADP+FAD CYP2J2 Acetaminophen (TNTYLENOL)O27alpha-hydroxycholesterolO2VACVH+CYP2A13 4OH-EST17bPEACytochrome P450(CYP2C9 based)NADHH2OCYP51A1O2BPHLH2ONH3RFNACYP2E1 O2atRAH+H+NH3H+CYP4F2 CXPAH2OCYP2C19 O2O24CHOL7aOLONENADP+ADH7 FDX1L NADPHO24CHOL7a,12a,24(S)TONECH3COO-CYP2C9 H+24OH-CHOLCYP4F2 NADP+O2TYRNADP+FMO2 CHESTH2ONADP+H2Ohydroxydocosahexaenoic acidH2NADPHCYP2C18 CYP2E1 NADPHCYP4F12 4,4DMCHtOLNADP+NADP+CYP4F11 NADP+AOC3 CYP2A13 CYP2C18 CYP2A13 ANDSTHistH2O3AAPNALNH34CHOL7a,12a,27TONE3OH-PALMCytochrome P450(CYP2F1 based)CYP3A4 CYP3A4 ALDH2 tetramerNADPHH+ALDH1B1 tetramerBZAMPPiH2ONADPHCa2+ 5HTCYP1A2H2O2TXA2O2H+H2OCYP2C8 CYP4F11 CYP26C1 O2O2CYP2E1 CHOL7a,24(S)DIOLTCDD Cytochrome P450(CYPIIIA4 based)H2OH+PHENresveratrolCytochrome P450(CYP2B6 based)CYP4A11 RXRA CYP11B2CHOLO2NADP+Aryl hydrocarbonreceptor signallingNADPHS-FGSHCYP3A5 ARNT H2OCytochrome P450(CYP7B1 based)PTGS1 NADPHCYP2B6 4-ethoxyanilineH2OCES1 O2H2O25(OH)DH2OPAOX:FADH2O2H2OCYP450:Fe2+NADPHCl-O2NADP+O2CYP2E1 MAOB:FADNADP+NADPHO2O2e-O2PGH23AAPNALacetyl groupNADPHH+CYP2C9 NCOA2 O2OLMS3MEINH2OCYP1A111DCORT11,12-EET O2ALDH1B1 Cytochrome P450(CYP4F8 based)H+H+H2OAc-CoAATPCYP2A7 AOC2CYP7B1 H2OCytochrome P450(CYP2J2 based)CYP4F22 CYP2D6 H+VD3TBMAFB1CYP4B1 NADPHH2OH2O2NADP+NADP+NADPHO220OH-LTB4HOMZCYP2J2 H+RFDHNNADPHNADPH14,15-EET CH2OO2CYP4F8 CYP4F3 O2FAD CH3CHONADP+O2Cytochrome P450(CYP2C8 based)TAMOadenosine5'-monophosphateNQO2 H2OH+LosecH+H2OFDXR H+O2NADPHNADP+MTZ-SOXO2MyrG-CYB5R3(2-301) FMO1 CYP2A7 AOC3dimer:2xCu2+:4xCa2+4OH-atRACytochrome P450(CYP2E1 based)NADP+H2OH2OMg2+ MeOHCYP2A13 CYP2B6 AHR:TCDD:ARNTNADPH24OH-CHOLCBR3CHOLH2OH+O2TESNADPHCYP2A7 NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHANCOA1 CYP2D6 PPiCYP2C9 hydroquinoneCYP2S1 H+CYB5B CYP2A13 CYP2C9 H2OCMBLCYP2F1 NADPHLCFA(-)CAFCytochrome P450(CYP8B1 based)O2PAOX NADPHCYP4F2 NADPHNADP+CYP4 NADPHMARC1 NADPHARNT2 CYP46A1HDBQPTGIS,CYP8B1DOX18HCORSTEtOHCYP4B1 NADP+H+O2NADP+CYP2B6 NADPHNADP+H2OH2ONH3H2OPhOHNADPHCYP2D6 CYP2C9 H+NADPHCYP26A1,B1,C1HCPMFAD NAD+CYP4A22 25(OH)DCYP2C19 CYP2S1H+O2E1NADHCYP7B1 SMOX-3HALONADP+CDCA FAD alcoholdehydrogenasecomplexCytochrome P450(CYP2A13 based)