Clathrin-mediated endocytosis (Homo sapiens)

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1, 21, 24, 28, 29, 32...20, 24, 36, 50, 56...21, 24, 36, 48, 65...22, 63, 89, 101, 12727, 39, 97, 125, 1465, 19, 22, 24, 36...8, 23, 25, 36, 46...25, 46, 47, 13724, 4414, 34, 48, 65, 99...27, 39, 97, 125, 1463, 17, 24, 26, 36...2, 12, 17, 18, 24...12, 16, 18, 24, 29...37, 61, 94, 146, 15418, 24, 30, 35, 36, 53...24, 31, 43, 45, 68...4, 10, 49, 52, 1597, 10, 11, 16, 24...24, 29, 60, 79, 82...22, 41, 62, 63, 89...clathrin-coated endocytic vesiclecytosolUBC(457-532) UBC(77-152) EPS15L1 EPS15 p-Y371-CBL AP2M1 PL N4GlycoAsn-PalmS WNT5A(36-380) UBC(533-608) CLTC VAMP2 EPN1 NECAP2 SYT8 AP2B1 VAMP3 N-WASP UBA52(1-76) ARF6 AP2A1 LDLR VAMP7 CLTCL1 ACTR3 PiAP2A2(1-939) AGFG1 ADR ATP SNAP91 HGS UBC(609-684) CLTB CLTC UBC(609-684) UBC(229-304) p-6Y-EGFR ARRB1 SH3GL3 EGF STON1 AAK1 CLTC DAB2 PACSIN2 SNX9 UBB(77-152) VAMP3 pS-ADRB2 AP2S1 AP2M1 UBC(77-152) PACSIN3 AP2S1 TRIP10 EPN1 DNM2 UBC(153-228) GDP CHOL AVP(20-28) AP-2 YXXPhi cargo N4GlycoAsn-PalmS WNT5A(36-380) HIP1 ITSN1 STAM2 STON2 SH3GL1 VAMP7 STAM2 EPN2 NECAP2 CLTC CLTA CLTA DAB2 ARPC1A AVP(20-28) NECAP2 p-Y850 EPS15 CLTCL1 EPN2 SGIP1 VAMP8 AAK1 AVP(20-28) SYT8 VAMP8 AAK1 DAB2 FNBP1 VAMP2 SYT2 SNAP91 SYT1 AP2A2(1-939) TAGs TRIP10 TAGs p-6Y-EGFR AGTR1 AP2M1 SYT9 STAM ARRB2 SH3KBP1 TRIP10 EPS15L1 AP2A1 SH3GL1 PiLDLRAP1 REPS2 DAB2 SH3KBP1 UBC(77-152) NECAP1 DAB2 VAMP7 APOB(28-4563) STAM2 p-DVL2 ADR RPS27A(1-76) AGFG1 NECAP2 GAK UBC(305-380) NECAPsSTAM2 AVPR2 AVP(20-28) PICALM STAM p-DVL2 BIN1 SNX18 SYT11 SGIP1 SH3GL1 CLTC VAMP3 p-Y371-CBL ITSN1 ARPC3 AP2B1 Cargo recognitionforclathrin-mediatedendocytosisPACSIN2 p-Y850 EPS15 AP2A2(1-939) UBC(305-380) UBB(153-228) GRB2-1 ARRB1 HSPA8 UBC(1-76) EPS15 LDLR DNAJC6 SYT8 TAGs UBC(609-684) ACTR2 FNBP1L AP2A2(1-939) AP2A2(1-939) SYNJ1 PI(4,5)P2 DNM3 UBB(1-76) STAM VAMP3 p-DVL2 ACTR2 DNM1 HIP1R PI(4,5)P2 AP2M1 EPS15 SNAP91 STON2 PI(4,5)P2 SYT2 HIP1 RPS27A(1-76) LDLRAP1 UBC(533-608) UBC(381-456) UBC(77-152) SH3GL1 cholesterol esters p-Y371-CBL GGC-RAB5B GTP EGF ATP ADPUBC(153-228) DNM2 SGIP1 STAM2 FZD4 EPS15L1 PL OCRL EPN1 EPS15 CLTCL1 PL RPS27A(1-76) CHRM2 LDLR AP2B1 SGIP1 LDLR EPN1 p-T156 AP2M1 PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1UBC(77-152) OCRL SYNJ1 TACR1 UBB(77-152) UBC(457-532) STAM CLTA PI(4,5)P2 REPS2 ARRB2 DNM3 REPS2 AP2A2(1-939) UBC(77-152) f-actin CLTCL1 UBC(1-76) RPS27A(1-76) STAM N4GlycoAsn-PalmS WNT5A(36-380) LDLRAP1 OCRL LDLRAP1 p-Y371-CBL ITSN1 ITSN2 UBC(1-76) AP2A2(1-939) SYT8 EPS15L1 CTTN AVPR2 DNM1 VAMP2 clathrin:HSPA8:ADPSH3GL3 AVP(20-28) FZD4 SGIP1 ARRB2 AGFG1 UBC(533-608) SYT11 PICALM UBB(77-152) ADR PI4PEGF SYT2 ARPC4 VAMP7 LRP2 STAM STAM2 AMPH ARPC4 ARRB2 GRB2-1 NECAP2 HSPA8 SYT2 N-WASP AP-2 YXXPhi cargo STAM BIN1 UBC(457-532) EGF GGC-RAB5C FNBP1 ITSNsp-Y850 EPS15 UBC(457-532) PIK3C2API(4)P:p-T156AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJsSYT2 CLTA FZD4 UBC(305-380) CLTC SYT1 OCRL EPS15 HIP1R UBC(305-380) AP2A2(1-939) ITSN1 DNM3 LDLRAP1 TACR1 EPS15 ARRB2 PL p-Y850 EPS15 BIN1 ARRB1 NECAP1 PICALM TRIP10 NAd p-AVPR2 GGC-RAB5A cholesterol esters ARPC3 p-T156 AP2M1 FZD4 UBC(1-76) SNX9 CLTB GAPVD1 AP-2 dileucine-containing cargo ADR AP2A1 ATP PI(4,5)P2:p-T156AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2AATP ARPC1A AP-2 dileucine-containing cargo SNAP91 PI4P CLASP proteins:cargoVAMP7 ACTR3 SNAP91 NECAP1 AP-2 dileucine-containing cargo SYT9 EPN1 UBC(381-456) CLTA SYT11 PACSIN3 EPN1 EPS15 PACSIN3 AP2B1 GRB2-1 GGC-RAB5B SNX18 UBC(533-608) UBC(77-152) EGF AGFG1 EPS15 N4GlycoAsn-PalmS WNT5A(36-380) ARRB1 UBB(1-76) AP2A2(1-939) EPN2 SH3GL2 SNX9 NECAP1 EPS15L1 STON1 AP-2 ComplexPL AP2B1 HIP1 UBC(77-152) TAGs EPS15L1 UBC(533-608) AP2B1 HGS PL LDLRAP1 REPS1 SYT11 SGIP1 UBC(1-76) SH3GL3 p-Y371-CBL p-6Y-EGFR HGS AGFG1 AAK1 EPN1 SH3KBP1 DNM3 STAM2 FNBP1 p-T156 AP2M1 UBC(153-228) SYT9 UBC(1-76) AVP(20-28) AVP(20-28) EPS15EPS15 cholesterol esters ITSN2 CHRM2 AP2A2(1-939) CLTA SH3GL3 STON1 UBC(229-304) AP2B1 ITSN1 SYT2 AP-2 YXXPhi cargo ADPOCRL REPS1 SYT11 AP2B1 SH3KBP1 p-DVL2 FNBP1 NECAP1 ITSN2 UBC(153-228) CLTA NECAP1 ATPEGF AP2M1 GRB2-1 HIP1R VAMP7 VAMP2 LDLRAP1 HSPA8:ATPUBC(533-608) LDLR STON1 ITSN2 CLTCL1 SGIP1 LDLR AP2A1 PI(4)P:p-T156AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinAP2M1 SH3GL2 FCHO1 EPS15 N4GlycoAsn-PalmS WNT5A(36-380) ARPC2 GAPVD1 EPS15 p-DVL2 GRB2-1 AP2M1 GTP UBC(229-304) STAM2 AAK1 UBC(457-532) DNM3 ADR GDP AP-2 YXXPhi cargo UBB(77-152) EPN2 FZD4 UBC(533-608) UBA52(1-76) VAMP7 GAK UBB(153-228) VAMP3 SH3GLsDNM:GTPGDP UBC(229-304) EGF DNM3 GAK SGIP1 TAGs SH3KBP1 AMPH CLTC UBC(381-456) EPN1 GAK AP2M1 EPS15L1 PiSYT1 CLTC CHRM2 N4GlycoAsn-PalmS WNT5A(36-380) PICALM ITSN2 ITSN2 CLTCL1 UBA52(1-76) VAMP2 CHOL UBC(381-456) VAMP8 EPN1 PICALM EPN1 ARRB2 UBB(153-228) CLTB AP2A2(1-939) UBC(229-304) UBC(609-684) p-6Y-EGFR CHOL CLTA FCHO1 ADR NECAP1 PACSIN1 AP-2 YXXPhi cargo AP2A2(1-939) N4GlycoAsn-PalmS WNT5A(36-380) AAK1UBB(77-152) AP2A1 CLTB UBC(609-684) UBC(77-152) AP2M1 CLTB AGFG1 clathrin triskelionEPS15L1 GAPVD1 AGTR1 PACSIN1 BIN1 SH3GL1 AP2S1 SGIP1 AP2A1 ARPC2 NECAP2 ATP HIP1R SYT8 CLTC AP2B1 ITSN2 CLTA UBC(381-456) SYNJ2 CLTC AP2A1 APOB(28-4563) SYT8 ADP NECAP1 ARRB2 UBA52(1-76) p-T156 AP2M1 FZD4 STAM2 SYT2 CHRM2 AP2M1 CLTCL1 CTTN GTP SGIP1 pS-ADRB2 AP2S1 AVPR2 p-Y371-CBL p-6Y-EGFR cholesterol esters TRIP10 PI4PSNX18 PACSIN2 FNBP1L UBB(153-228) TACR1 NECAP2 FCHO1 SYT11 DNM1 AAK1 HIP1 TACR1 APOB(28-4563) REPS1 SGIP1 EPS15 STON2 UBC(305-380) LRP2 PACSIN1 TAGs AAK1 AAK1 PACSIN2 STON2 UBC(1-76) UBC(381-456) STON2 UBC(305-380) ARPC5 SYT1 p-T156 AP2M1 AP2A2(1-939) CHOL ITSN1 SNX18 CLTB FNBP1L AP2A2(1-939) ARPC2 ARPC1A RPS27A(1-76) CTTN RPS27A(1-76) p-AVPR2 UBC(229-304) VAMP2 DNM2 PL PI(4)P:p-T156AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinRPS27A(1-76) HIP1R AGTR1 ARPC5 APOB(28-4563) SYT11 p-AVPR2 SNX18 AP2A1 SYT11 AVP(20-28) AP-2 dileucine-containing cargo OCRL LRP2 SNAP91 UBC(1-76) N-WASP HGS N-WASP SYT9 SH3GL1 EPS15L1 ARPC3 AVPR2 UBC(1-76) BIN1 p-6Y-EGFR SYT2 ARPC1A SGIP1 SYNJ2 ARRB2 UBC(77-152) ATP AGTR1 UBC(229-304) AP2B1 UBB(77-152) EPS15L1 FNBP1 TACR1 UBB(1-76) AP2A2(1-939) STAM2 AP2M1 UBC(229-304) CLASP proteins:cargoEGF p-Y371-CBL REPS2 EGF GRB2-1 FZD4 p-DVL2 EPN2 CLTA FNBP1L CLTA DNAJC6 REPS2 UBC(381-456) NAd AAK1 CLTC SYNJs,OCRLREPS1 CHRM2 p-6Y-EGFR UBC(533-608) SYNJ2 SNX9 UBC(609-684) DAB2 ITSN2 UBC(153-228) STAM2 HGS clathrin triskelionUBC(1-76) GGC-RAB5B FNBP1L UBB(77-152) p-DVL2 PL RPS27A(1-76) ARPC5 REPS1 PI(4)P:p-T156AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJsREPS2 UBB(77-152) TAGs NAd AP-2 YXXPhi cargo SYT1 ACTR3 TAGs UBB(153-228) EPN2 AAK1 CHOL STON1 ARPC2 LDLR SYT9 PACSIN2 AP2A1 ADR STON1 PACSIN3 f-actin ACTR3 AP-2 YXXPhi cargo CLTC HGS UBB(153-228) EPN2 NECAP2 ARPC1A SYT11 CHOL REPS1 PICALM PI(4,5)P2:p-T156AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimersN-WASP AP-2 YXXPhi cargo ARPC4 GAK HGS ACTR3 UBC(533-608) PACSIN1 SH3KBP1 ARRB2 FCHO1 N4GlycoAsn-PalmS WNT5A(36-380) AP2A1 EPN1 p-Y850 EPS15 DNM1 ARPC2 PI(4)P:p-T156AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATPp-AVPR2 ARRB1 UBA52(1-76) SH3KBP1 CLTCL1 RPS27A(1-76) AP2M1 UBC(229-304) SYT8 UBB(153-228) ARPC1A AP2M1 PICALM PICALM SYT1 OCRL SYNJ2 CLTA AP2M1 TRIP10 dimerITSN1 APOB(28-4563) PACSIN3 DNM3 REPS1ATP VAMP2 UBC(153-228) SNAP91 pS-ADRB2 ARPC3 CLTC AP2B1 p-Y850 EPS15 AP2M1 GRB2-1 VAMP7 SYNJ1 CLTCL1 VAMP8 UBC(381-456) VAMP2 SYT8 SYT2 CLTC GTP AP2A1 AMPH GRB2-1 SYT9 PI(4,5)P2:AP-2:clathrinAP2A1 DAB2 AMPH REPS2 DNAJC6 CLTC HGS EPN2 SH3GL1 VAMP8 p-6Y-EGFR AP2M1 CLTC CLTC CLTA CLTA ARFGAP1 AAK1 UBC(305-380) UBC(609-684) SYT11 AGTR1 AP2S1 ARRB2 ARPC4 CLTB UBB(153-228) UBB(153-228) AP2M1 AP2S1 SGIP1 NECAP2 AP2A2(1-939) TAGs ARPC2 UBC(609-684) UBC(457-532) BIN1 STON1 AP2B1 pS-ADRB2 CHRM2 AP-2 YXXPhi cargo N-WASP cholesterol esters HIP1R CHRM2 CLTA AP2S1 SH3GL3 AP2S1 FZD4 DNAJC6 VAMP8 UBB(77-152) UBC(305-380) AGTR1 N4GlycoAsn-PalmS WNT5A(36-380) GGC-RAB5C FNBP1 dimerFCHO1 DNM1 ARPC5 EPN2 TAGs UBB(1-76) HIP1 AP-2 dileucine-containing cargo NECAP1 p-6Y-EGFR SH3GL1 AMPH SYT11 NECAP1 AGTR1 UBC(381-456) STON2 NAd AGFG1 EGF p-Y371-CBL CTTN STON1 PI4P cholesterol esters PI(4,5)P2UBC(153-228) CHRM2 SH3GL2 AP2A1 UBA52(1-76) SYT8 UBC(457-532) CHOL SNX9 SYT9 N4GlycoAsn-PalmS WNT5A(36-380) VAMP3 UBC(457-532) AP2B1 SYNJ1 UBB(1-76) VAMP8 SYT9 GRB2-1 VAMP7 SNX18 AP2B1 AVPR2 AP2B1 SH3GL1 CLTCL1 pS-ADRB2 AMPH:BIN1SGIP1 VAMP8 VAMP3 VAMP8 CLTA CHOL UBB(153-228) BIN1 BIN1 SGIP1 UBC(305-380) ITSN1 UBC(305-380) p-DVL2 UBC(1-76) UBC(305-380) REPS2 PACSIN1 APOB(28-4563) PI(4,5)P2 CLTA HIP1R SYT1 ARPC5 CLTB cholesterol esters AP-2 dileucine-containing cargo AGTR1 CLTC ACTR2 N-WASP CHOL REPS2 ARPC5 AP2B1 TACR1 ATP AVP(20-28) CLTA PACSIN1 GGC-RAB5A EPN1 PI4P TAGs PACSIN1 CLTC AP2A2(1-939) pS-ADRB2 EGF p-T156 AP2M1 STAM SNAP91 SNAP91 PACSIN2 AP-2 YXXPhi cargo ADR EPS15 APOB(28-4563) ACTR2 GTP TACR1 CTTN CHOL LRP2 ARPC3 SYT2 HGS DNM1 SH3GL2 p-Y371-CBL FNBP1 SGIP1 CLTC ARPC2 pS-ADRB2 AP2A2(1-939) SNX9 EPN2 ADR DNAJC6 ITSN2 SYT9 STAM2 AVP(20-28) REPS1 AAK1PIK3C2A AVP(20-28) UBC(229-304) CHRM2 DNM2 UBC(533-608) AGTR1 FNBP1 p-AVPR2 ARPC3 UBB(77-152) AP2A2(1-939) EGF p-6Y-EGFR TACR1 pS-ADRB2 REPS1 ACTR2 EPN2 ARPC5 p-T156 AP2M1 APOB(28-4563) AGFG1 FZD4 REPS2 p-6Y-EGFR REPS2 ACTR2 SNAP91 SH3KBP1 pS-ADRB2 UBC(457-532) GGC-RAB5:GDP:GAPVD1UBA52(1-76) LDLRAP1 HIP1 UBC(609-684) UBB(1-76) UBB(1-76) STON1 AVP(20-28) p-AVPR2 ARPC5 DAB2 p-Y371-CBL LRP2 FCHO2 SH3GL2 PI(4,5)P2:p-T156AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1CLTCL1 AP2A2(1-939) UBB(1-76) AP2A1 FNBP1L TACR1 PL FCHO1 HIP1R LDLRAP1 SH3GL2 ARFGAP1:ARF6:GTPp-DVL2 STON1 GDP p-Y371-CBL AP2B1 SYNJ1 LDLRAP1 AP-2 YXXPhi cargo AP2S1 PACSIN2 EPS15 SH3GL2 APOB(28-4563) EPN1 NECAP2 AP2S1 REPS2 HIP1R UBB(1-76) p-DVL2 ADR GAK EGF HGS AP2A2(1-939) LDLRAP1 p-T156 AP2M1 PI(4,5)P2 AP2A2(1-939) N4GlycoAsn-PalmS WNT5A(36-380) EPN1 NECAP1 PICALM DNM1 LRP2 CHOL UBC(1-76) EPS15L1 p-Y371-CBL CLTCL1 EPS15 SH3GL3 APOB(28-4563) SYT11 CLTC CLTCL1 AGTR1 SH3GL1 HGS UBC(153-228) ACTR3 APOB(28-4563) ARRB1 STAM AP2M1 AGFG1 N-WASP ARPC4 VAMP8 CHRM2 TRIP10 SNX18 SH3GL3 UBC(609-684) REPS2 cholesterol esters ADR UBB(153-228) GRB2-1 UBC(229-304) SH3GL2 p-Y371-CBL UBB(1-76) AP2S1 ATP AP2A1 SYT1 AP-2 ComplexLRP2 UBA52(1-76) FCHO2 ITSN2 STON2 UBC(77-152) AGTR1 ACTR3 CTTN REPS1 SYT9 AP2B1 f-actin VAMP7 AP2B1