PTEN Regulation (Homo sapiens)

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1-4, 7, 8, 10...2327, 34, 37, 693671254, 648, 27, 32, 34, 37...839, 63234972, 2023745, 6971477137, 2311, 524, 6, 7, 23, 26...4973850, 564, 5847, 485, 11, 13, 16, 18...45812, 423333625, 51, 661324436722, 653231, 4677, 333323, 6776, 2623, 6729, 507024cytosolnucleoplasmlysosomal membraneRCOR1 PREX2PolyUb-PTENmiR-17 RISC:CNOT6LmRNAEIF2C4 EIF2C3 CHD3 PTEN mRNA PolyUb-PTEN miR-106b HDAC2 EIF2C4 PSMD9 PTEN gene UBB(153-228) MOV10 PTEN mRNA miR-93:PTEN mRNAmiR-106 RISC:VAPAmRNAAGO2 RPTOR miR-214 RPS27A(1-76) miR-106a miR-20b miR-20b TNRC6A miR-20b UBC(609-684) UBC(381-456) NAMMTA3 UBB(153-228) EIF2C4 EIF2C1 AGO2 miR-106a p-T69,T71-ATF2 UBC(229-304) HDAC1 UBC(457-532) TNRC6A RPS27A(1-76) p-T309,S474-AKT2 EIF2C3 JUN:PTEN geneUBC(305-380) CBX8 GATAD2B PSMB9 TNRC6C GATAD2A TNRC6A TNRC6A miR-17 miR-22 RISC:PTENmRNAPTEN mRNAMOV10 CBX6 MTOR MOV10 miR-20 RISC:PTENmRNATNRC6A PTEN mRNA UBC(381-456) EED HDAC1 miR-20b TNRC6B CSNK2A2 PHC2 CHD3 miR-106 RISC:PTENmRNAEIF2C1 UBC(457-532) miR-93 TNRC6B miR-22 UBC(229-304) NuRD complexTNRC6C miR-19a RISCp-T308,S473-AKT1 TNRC6C MTORC1:Ragulator:Rag:GNP:RHEB:GTPmiR-26A1 PSMA4 MOV10 ADPATPPSMC2 AGO2 miR-20a MOV10 UBC(1-76) GDP UBC(533-608) EIF2C3 TNRC6B EIF2C1 EED AGO2 EIF2C3 p-S60,S68,S75-MAF1p-T305,S472-AKT3 TNRC6B miR-19a EIF2C1 UBC(533-608) UBB(1-76) MOV10 TNRC6B MOV10 miR-19b2 CBX2 UBC(1-76) MAF1PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTENPSMD14 UBC(533-608) TNRC6A PTEN gene CSNK2A1 PTEN gene PTEN mRNA EIF2C4 AGO2 miR-205 TNRC6C HDAC3,5,7 PPARG PTEN mRNA TNRC6C UBB(77-152) PMLADPEIF2C1 EIF2C3 HDAC2 miR-25 RISCmiR-17 RISC:VAPAmRNAEIF2C4 PHC3 TNRC6C PTENP1 mRNA ATPTNRC6A TP53 ATPPHC2 EIF2C3 EIF2C1 UBC(153-228) PTEN gene TNRC6A UBA52(1-76) UBC(609-684) UBC(77-152) EIF2C1 TNRC6B CNOT6L mRNA TNRC6C Actos UBC(153-228) TNRC6C miR-19b RISC:CNOT6LmRNANR2E1 RGZ TNRC6A PTEN gene EGR1 EIF2C3 miR-20 RISC:PTENP1mRNARBBP4 ATN1 MECOM UBB(77-152) EIF2C1 LAMTOR3 CSNK2B UbPSMB11 USP13 CBX2 PTENMOV10 UbTNKS PIP3 activates AKTsignalingEIF2C1 SHFM1 p-T202,Y204-MAPK3 PSMD11 MOV10 EIF2C3 p-3S,2T-PTEN miR-214 TNRC6A TNRC6B AGO2 miR-26A RISCmiR-19b1 PSMD6 MECOM:(PRC1.4,PRC2(EZH2) core):PTENgeneMonoUb-K13,K289-PTENTNRC6B VAPA mRNA EIF2C1 EIF2C3 UBA52(1-76) NEDD4 miR-19a RISC:CNOT6LmRNAMOV10 p-Y387-FRK miR-214NonendonucleolyticRISC:PTEN mRNASCMH1-2 PSMC4 TNRC6C PSMD7 LAMTOR1 GATAD2B PTEN UBC(153-228) TNRC6A PSMA3 REST PTEN gene EIF2C3 AGO2 TNRC6B EIF2C3 TNRC6C miR-25 RISC:PTENmRNAp-3S,2T-PTENAGO2 REST UBC(1-76) PSMB6 MTA1 miR-17 TNRC6B UBB(153-228) TNRC6B PSMD8 TNRC6C EIF2C3 PSME1 miR-19b1 EIF2C4 ADPEIF2C1 TNRC6C EIF2C1 TNRC6A TNRC6C AGO2 miR-93 PolyUb-PTEN,K48polyUb-K289-PTENTNRC6A TNRC6B EIF2C1 EIF2C4 AGO2 TNRC6B UBC(381-456) PSMA1 TNRC6A EIF2C4 UBB(153-228) RRAGC EIF2C1 MOV10 NEDD4,STUB1,WWP2 andXIAPEIF2C3 UBC(533-608) TNRC6B UBC(457-532) RibC-E40,E150,D326-PTENEIF2C3 AGO2 TNRC6C RPS27A(1-76) UBC(305-380) EIF2C4 PHC1 UBC(533-608) K48polyUb-K289-PTEN miR-20a TNRC6C MAF1 TNRC6C GATAD2A SCMH1-2 PTEN PSMF1 UBC(457-532) MOV10 RNF146JUN AGO2 AGO2 p-T69,T71-ATF2:PTENgenemiR-19a RISC:VAPAmRNAUBB(1-76) PTEN RBBP4 miR-26A2 miR-19a EGR1:PTEN geneTNRC6B TNRC6B TP53 TetramerEIF2C4 13(S')-HODE TNRC6C EIF2C4 EIF2C1 RGZ LAMTOR5 H2OMKRN1UBB(77-152) RRAGD RING1 EIF2C4 miR-106b MOV10 UBC(77-152) PSMB2 TNRC6A EIF2C1 TNRC6B CNOT6L mRNA UBC(609-684) RPS27A(1-76) SNAI1 UBB(77-152) TNRC6C miR-20b miR-25 p-S109-MKRN1RPS27A(1-76) MOV10 miR-106b MAF1XIAP PSMB1 PTEN mRNA:miR-26ARISCEIF2C4 EIF2C3 PPARG:Fatty AcidLigandK48polyUb-K289-PTEN miR-22 RISCMOV10 TNRC6A miR-106 RISCmiR-20a TNRC6C TNRC6C EIF2C3 RHEB PTEN:TRIM27PHC3 MOV10 SNAI2 UBA52(1-76) EIF2C3 CBX8 NR2E1:(CoRESTcomplex,ATN1,HDAC3,HDAC5,HDAC7)UBC(533-608) miR-214NonendonucleolyticRISCOTUD3 PPARG:Fatty AcidLigand:PTEN genePSMA7 UBC(609-684) miR-21 PTENP1 mRNA miR-19a UBC(381-456) MECOM PSMB10 EIF2C3 MECOM:PTEN geneUBB(77-152) STUB1 PolyUb-PTEN,K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTENPSMD12 EIF2C3 PSMD5 UBC(1-76) EIF2C4 K48polyUb-K289-PTENUBB(153-228) ATN1 miR-17 CHD4 Actos miR-19b2 AGO2 miR-106a TNRC6A miR-106 RISC:CNOT6LmRNAUSP7EIF2C3 UBB(1-76) PTEN mRNA MECOMEIF2C3 AGO2 MOV10 MOV10 AGO2 UBC(609-684) TNRC6B LAMTOR2 EIF2C1 Casein kinase IIRRAGA AGO2 miR-22 miR-26A1 TNRC6A miR-205 RISC:PTENmRNAEIF2C4 TNRC6C PSMB8 PSMD1 MOV10 TNRC6A AGO2 EIF2C3 RBBP7 NAD+EIF2C3 EIF2C1 EIF2C3 TNRC6A PTEN geneUBC(229-304) MOV10 VAPA mRNA HDAC2 UBC(457-532) RBBP4 TNRC6B HDAC3,5,7 PSMC5 miR-20 RISC:VAPAmRNASNAI1,SNAI2:PTENgeneUBC(305-380) AGO2 EIF2C3 MOV10 VAPA mRNA p-Y387-FRKEIF2C4 26S proteasomePSMB4 UBA52(1-76) AGO2 PSME3 13(S')-HODE PSMA8 MOV10 ADPEIF2C4 PRC1.4,PRC2 (EZH2)corePSMA2 RBBP4 EIF2C1 UBC(305-380) EIF2C4 TNRC6B PTEN gene MBD3 miR-19b2 PolyUb-PTEN MAF1:PTEN geneCBX4 EIF2C4 JUNMOV10 PSMB7 PSMD4 UBC(229-304) PTEN, p-3S,2T-PTENEIF2C4 RING1 PTEN gene UBB(77-152) PSMC3 miR-19b RISC:PTENmRNAPSMA6 CBX6 PSMD2 PPARG miR-19b2 CNOT6L mRNATNRC6B MOV10 SALL4 PTEN mRNA TNRC6B UBC(229-304) miR-205 EIF2C4 PHC1 AGO2 TNRC6B RBBP7 TNRC6A p-T,p-S-AKTEIF2C4 miR-21NonendonucleolyticRISCTNRC6C EIF2C4 miR-17 RISC:PTENmRNACNOT6L mRNA SNAI1,SNAI2EIF2C1 PSMB5 AGO2 miR-106b KDM1A EGR1MLST8 TRIM27USP13,OTUD3HDAC2 PSMD3 TNRC6A miR-19a RISC:PTENmRNAEIF2C4 MOV10 MonoUb-K13,K289-PTENRCOR1 EIF2C4 TNRC6B TNRC6A MTA2 UBC(229-304) EIF2C4 TNRC6B TNRC6A EIF2C3 TNRC6A BMI1 RNF2 PTEN PSMD10 SALL4:PTEN geneTNRC6B miR-19b RISC:PTENP1mRNAEIF2C4 UBC(457-532) TNRC6A UBC(1-76) UBC(77-152) MOV10 SALL4 TNRC6C TNRC6A PTENNR2E1 BMI1 EIF2C3 TNRC6A miR-25 CNOT6L mRNA miR-17 EIF2C4 UBC(77-152) PSMC6 RNF2 UBB(1-76) TNRC6B miR-21 SLC38A9 UbTNRC6C miR-93 RISCSNAI1 miR-205 RISCEIF2C3 miR-20a PTEN mRNA RBBP7 PTEN mRNA LAMTOR4 PTEN:p-Y387-FRKTNRC6C EIF2C3 PTEN mRNA TNRC6A p-T,Y MAPK dimersAGO2 RRAGB RBBP7 SNAI2 PSMD13 MOV10 EZH2 MOV10 PSMB3 TNRC6B TNRC6B EIF2C1 EZH2 SALL4:NuRD:PTEN genemiR-19b1 miR-19b RISCPSME2 EIF2C3 UBA52(1-76) TNRC6A ATPMOV10 PREX2:PTEN,p-3S,2T-PTENmiR-21NonendonucleolyticRISC:PTEN mRNATNRC6B K27polyUb-PTENUBC(77-152) AGO2 EIF2C4 PTEN mRNA UBC(153-228) TP53 TNRC6C UBA52(1-76) MTA3 HDAC1 miR-19a EIF2C1 H2OKDM1A TNRC6C MTA2 miR-26A2 TNRC6C CHD4 AGO2 PTEN gene TNRC6C HDAC1 p-Y336-PTEN9S-HODE AGO2 MOV10 NR2E1:(CoRESTcomplex,ATN1,HDAC3,HDAC5,HDAC7):PTEN GeneTNRC6B UBC(1-76) AGO2 SUZ12 EIF2C4 PSMC1 VAPA mRNAEIF2C3 XIAP,NEDD4EIF2C4 UBC(305-380) TNRC6C UbmiR-20 RISCmiR-17 RISCmiR-19b1 PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN EIF2C3 miR-20a EIF2C4 p-3S,2T-PTEN UBC(381-456) GTP MOV10 MTA1 TNRC6A TNRC6A MOV10 TNRC6B AGO2 PSMA5 TNRC6B PTENP1 mRNAMOV10 EIF2C1 EIF2C4 PREX2 MBD3 AGO2 TNRC6A EIF2C1 RPS27A(1-76) CBX4 SUZ12 EIF2C1 EIF2C1 TNRC6C miR-106a PTEN gene EIF2C3 AGO2 WWP2 CNOT6L mRNA AGO2 XIAP PTEN gene EIF2C3 VAPA mRNA TNKS1/2p-T69,T71-ATF2TRIM27 SALL4TNRC6B TNRC6A MOV10 EIF2C1 PSME4 EIF2C1 UBB(1-76) UBC(305-380) UBC(153-228) UBB(153-228) EIF2C1 TNRC6B EIF2C4 EIF2C3 EIF2C1 UBC(609-684) TNRC6C miR-20 RISC:CNOT6LmRNAEIF2C1 EIF2C1 EIF2C4 UBB(1-76) EIF2C1 NEDD4 TP53 Tetramer:PTENGeneEIF2C1 TNRC6C UbPTEN mRNA TNRC6A p-T185,Y187-MAPK1 TNRC6C TNKS2 UBC(381-456) UBC(153-228) Ub9S-HODE PTEN gene UBC(77-152) TNRC6C MOV10 EIF2C1 731, 4673362133577, 33243335, 557775, 51, 666, 262, 2023, 677, 2347, 489, 2861711, 525, 51, 6649712, 20750, 562322, 6523, 67703354, 642, 2029, 5023613238444723