Selective serotonin reuptake inhibitors lead to several adverse outcomes (Homo sapiens)

From WikiPathways

Jump to: navigation, search
Intracellular Ca2+StressDepressionPhospholipase CSSRI5-HTRHTR2ACortisoneNeuroplasticityVascular smooth muscle contractionBDNFIntracellular Na+HypertensionExtracellular norepinephrineAgitationCalmodulinExtracellular serotoninSLC6A4Glucocorticoid receptorInositol trisphosphateMyosin light chain phosphorilationSynaptic releaseIntracellular Cl-SeizureHTR3AExtracellular Cl-Exracellular Na+Intracellular serotoninPackaged serotonin


Description

Adverse Outcome Pathway (AOP) for Selective serotonin reuptake inhibitors (SSRIs), originating from the AOPXplorer app for Cytoscape.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
96738view05:52, 2 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96281view08:24, 5 March 2018EgonwNot a mim:conversion.
93133view13:30, 31 July 2017Marvin M2Connected an unconnected arrow
92898view09:17, 15 July 2017EgonwOntology Term : 'disease pathway' added !
92866view17:22, 10 July 2017Marvin M2Modified description
92865view17:21, 10 July 2017Marvin M2Modified title
92864view15:32, 10 July 2017Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5-HTR
Agitation
BDNFGeneProductENSG00000176697 (Ensembl)
CalmodulinProteinE7EMB3 (Uniprot-TrEMBL)
CortisoneMetaboliteCHEBI:16962 (ChEBI)
Depression
Exracellular Na+MetaboliteCHEBI:29101 (ChEBI)
Extracellular Cl-MetaboliteCHEBI:17996 (ChEBI)
Extracellular norepinephrineMetaboliteCHEBI:33569 (ChEBI)
Extracellular serotoninMetaboliteCHEBI:28790 (ChEBI)
Glucocorticoid receptorProteinE5KQF5 (Uniprot-TrEMBL)
HTR2AGeneProductENSG00000102468 (Ensembl)
HTR3AGeneProductENSG00000166736 (Ensembl)
Hypertension
Inositol trisphosphateMetaboliteQ138145 (Wikidata)
Intracellular Ca2+MetaboliteCHEBI:29108 (ChEBI)
Intracellular Cl-MetaboliteCHEBI:17996 (ChEBI)
Intracellular Na+MetaboliteCHEBI:29101 (ChEBI)
Intracellular serotoninMetaboliteCHEBI:28790 (ChEBI)
Myosin light chain phosphorilation
Neuroplasticity
Packaged serotoninMetaboliteCHEBI:28790 (ChEBI)
Phospholipase CMetaboliteQ420248 (Wikidata)
SLC6A4GeneProductENSG00000108576 (Ensembl)
SSRIMetaboliteCHEBI:50949 (ChEBI)
Seizure
Stress
Synaptic release
Vascular smooth muscle contractionPathwayWP3811 (WikiPathways)

Annotated Interactions

No annotated interactions

Personal tools