Steatosis AOP (Homo sapiens)

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SteatosisCytosolic fatty acidsAKT1S1RICTORMLST8NFE2RPTORSREBF1MTORNR1H2TELO2NR1H4PI3KSCDMTORNR0B2PRKCIMAPKAP1MLST8PPARGINSRFABP1AKT2FASNHSD17B4LipogenesisAKT1TTI1DEPTORNR1H3InsulinFatty Acid Beta OxidationPPARANR5A2


Description

Adverse outcome pathway for steatosis, originating from the AOPXplorer app for Cytoscape (http://apps.cytoscape.org/apps/aopxplorer).

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
95967view12:55, 10 February 2018EgonwConverted a metabolic species to a Metabolite DataNode with ChEBI ID.
95966view12:53, 10 February 2018EgonwConverted mim-conversions to arrows for gene-gene and protein-protein.
93132view13:22, 31 July 2017Marvin M2Ontology Term : 'disease pathway' added !
92712view13:11, 29 June 2017Marvin M2Ontology Term : 'fatty liver disease' added !
92711view13:09, 29 June 2017Marvin M2Modified description
92710view13:09, 29 June 2017Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
Cytosolic fatty acidsMetaboliteCHEBI:35366 (ChEBI)
DEPTORGeneProductENSG00000155792 (Ensembl)
FABP1GeneProductENSG00000163586 (Ensembl)
FASNGeneProductENSG00000169710 (Ensembl)
Fatty Acid Beta OxidationPathwayWP143 (WikiPathways)
HSD17B4GeneProductENSG00000133835 (Ensembl)
INSRGeneProductENSG00000171105 (Ensembl)
InsulinProteinA6XGL2 (Uniprot-TrEMBL)
LipogenesisPathwayWP3965 (WikiPathways)
MAPKAP1GeneProductENSG00000119487 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NFE2GeneProductENSG00000123405 (Ensembl)
NR0B2GeneProductENSG00000131910 (Ensembl)
NR1H2GeneProductENSG00000131408 (Ensembl)
NR1H3GeneProductENSG00000025434 (Ensembl)
NR1H4GeneProductENSG00000012504 (Ensembl)
NR5A2GeneProductENSG00000116833 (Ensembl)
PI3KGeneProduct
PPARAGeneProductENSG00000186951 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PRKCIGeneProductENSG00000163558 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
SCDGeneProductSCD (HGNC)
SREBF1GeneProductENSG00000072310 (Ensembl)
TELO2GeneProductENSG00000100726 (Ensembl)
TTI1GeneProductENSG00000101407 (Ensembl)

Annotated Interactions

No annotated interactions

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