Liver steatosis AOP (Homo sapiens)

From WikiPathways

Jump to: navigation, search
11, 1611, 1611, 161011, 16Fatty acid lysisgenesAhR Target genesCAR Target genesMitochondrialBeta-oxidationgenesCAR coregulatorsFAS genesLXR Target genesMIE(KE:10101)KE(KE:10201)LDLRMitochondrialBeta-oxidationKE(KE:10102)HMGCS2CytoplasmdisplacementMIE(KE:228)PXR activationMIE(KE:227)LXR activationFatty LivercellsEndoplasmicreticulum stressMIE(KE:245KE(KE:10201)KE(KE:258)KE(KE:1214)Triglyceride accumulationin LivercellsMIE(KE:167)CAR activationChREBPKE(KE:472)Fatty acid lysisHSD17B10SCDKE(KE:264)KE(KE:10201)SREBP-1cCPT1APPARAPPARDAhR activationKE(KE:66)AO(KE:345)KE(KE:466)KE(KE:474)KE(KE:116)KE(KE:10201)FOXA2KE(KE:860)KE(KE:471)FA influxFASKE(KE:115)Liver SteatosisKE(KE:54)PPARGKE(KE:10106)KE(KE:291)CD36De novoFA synthesisMIE(KE:18)KE(KE:10110)MitochondrialdisruptionNucleusdistortionKE(KE:89)CYP2C9ABCB163UGT1A119ABCC27CYP2A6CYP4A113CYP2C1976SULT1A1GSTA253CYP3A5SULT2A1614CYP3A4ALAS16EHHADH3CYP2B67ABCC36UGT1A47UGT1A68UGT1A98UGT1A38FOXO181NCOA6SP1NCOA1PPARGC1ANCOA2SMC1Ap27Kip113CYP1A1CYP1A218CYP1B12p21cip115, 17ABCG89CYP3A44ABCG59CYP2B64CYP7A14SREBF1FASN4SCD4PXR Target genesPXR coregulatorsCYP3A76UGT1A68UGT1A38UGT1A9CYP2A68UGT1A468SLCO1B112SRPX2NCOA3FOXO11CYP4F12CYP3A412UGT1A1612ABCC412NRIP1CYP2B6GSTA26PSMC512PPARGC1ANCOA1NCOA2ABCB112CYP2C9CYP3A56CYP2C1966SULT2A114ABCC24ABCC34SRCNCOA2NCOA3PSMC5NRIP1SRPX2PPARGC1AACSL4SCP2CPT2EHHADHACSL1DCIACADSHADHACPT1AACSL2ACSL3ACADLACADMACADVLHADHSCSLC25A20PECRECHS1ACSL5PECRECHDC2ACACAECHDC1ACSL4ACAS2ECHDC3ACLYFASNACSL3HADHSCACACBACSL1ACAA2MECRDECR1ACSL6ECH1PRKAR1BPRKAR2BATGLHSLPRKAG3PRKAG1ABHD5PRKACGPRKACAPRKAA1PRKACBPRKAB2PRKAB1PRKAA2PRKAG2PRKAR1APRKAR2Ade novoFA synthesisECHS1ACSL5PECRECHDC2ACACAECHDC1ACSL4ACAS2ECHDC3ACLYFASNACSL3HADHSCACACBACSL1ACAA2MECRDECR1ACSL6ECH1


Description

Liver steatosis AOP

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. ''''; , PubMed Europe PMC
  2. Quattrochi LC, Vu T, Tukey RH; ''The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports AH-receptor binding and promoter-specific induction.''; J Biol Chem, 1994 PubMed Europe PMC
  3. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC
  4. Handschin C, Meyer UA; ''''; , PubMed Europe PMC
  5. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC
  6. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC
  7. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC
  8. Bock KW; ''''; , PubMed Europe PMC
  9. Hashimoto K, Mori M; ''Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review].''; Endocr J, 2011 PubMed Europe PMC
  10. Brigitte Landesmann, Marina Goumenou, Sharon Munn, Maurice Whelan; ''Description of Prototype Modes-of-Action Related to Repeated Dose Toxicity ''; http://publications.jrc.ec.europa.eu/repository/bitstream/JRC75689/lb-na-25631-en-n.pdf, 2012
  11. Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck JR, Girard J, Postic C; ''Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.''; Diabetes, 2006 PubMed Europe PMC
  12. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC
  13. Kolluri SK, Weiss C, Koff A, Gأ¶ttlicher M; ''p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells.''; Genes Dev, 1999 PubMed Europe PMC
  14. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC
  15. Tang YM, Wo YY, Stewart J, Hawkins AL, Griffin CA, Sutter TR, Greenlee WF; ''Isolation and characterization of the human cytochrome P450 CYP1B1 gene.''; J Biol Chem, 1996 PubMed Europe PMC
  16. Mellor CL, Steinmetz FP, Cronin MT; ''The identification of nuclear receptors associated with hepatic steatosis to develop and extend adverse outcome pathways.''; Crit Rev Toxicol, 2016 PubMed Europe PMC
  17. Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K; ''Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.''; Drug Metab Dispos, 2001 PubMed Europe PMC
  18. Nebert DW, Petersen DD, Puga A; ''Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin.''; Pharmacogenetics, 1991 PubMed Europe PMC
  19. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.''; Hepatology, 2001 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
95148view03:34, 17 November 2017AlexanderPicofixed interactions
93179view11:11, 2 August 2017JJvdHeijdenMaking the AOP network (biological) more compact
93178view11:10, 2 August 2017JJvdHeijdenDeleted a error
93177view11:09, 2 August 2017JJvdHeijdenFatty acid lysis underling pathway added and colour of non-crossref IDs changed to red
93127view08:27, 31 July 2017JJvdHeijden
93126view08:25, 31 July 2017JJvdHeijdenAdded restored an earlier broken connection
93124view07:39, 31 July 2017JJvdHeijdenremoval of feedback loop
92719view07:58, 30 June 2017JJvdHeijdenAdded the missing line between KE466 and KE115
92709view13:00, 29 June 2017JJvdHeijdenAdded missing connections (in AOP network) from KE228 - KE264 and KE54
92708view12:23, 29 June 2017JJvdHeijdenCyt. Dis., Nuc. Dis., Mit. Dis., Endop. Ret. is now one single KE (KE:10201) Cellstress
92707view10:47, 29 June 2017JJvdHeijdenconnected KE:472 - KE:860 as was already displayed by the link between CPT1A and Mit. B-oxidation
92706view10:44, 29 June 2017JJvdHeijdenRemoval of some personal notes
92703view08:38, 29 June 2017JJvdHeijdenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB1GeneProduct5243 (Entrez Gene) ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB1GeneProductENSG00000085563 (Ensembl)
ABCC2GeneProduct1244 (Entrez Gene) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC3GeneProduct8714 (Entrez Gene) ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC3GeneProductENSG00000108846 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
ABCG5GeneProduct64240 (Entrez Gene) ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8GeneProduct64241 (Entrez Gene) ATP-binding cassette, sub-family G (WHITE), member 8
ABHD5GeneProductENSG00000011198 (Ensembl)
ACAA2GeneProduct10449 (Entrez Gene)
ACACAGeneProduct31 (Entrez Gene)
ACACBGeneProduct32 (Entrez Gene)
ACADLGeneProduct33 (Entrez Gene)
ACADMGeneProduct34 (Entrez Gene)
ACADSGeneProduct35 (Entrez Gene)
ACADVLGeneProduct37 (Entrez Gene)
ACAS2GeneProduct55902 (Entrez Gene)
ACLYGeneProduct47 (Entrez Gene)
ACSL1GeneProduct2180 (Entrez Gene)
ACSL2GeneProduct80221 (Entrez Gene)
ACSL3GeneProduct2181 (Entrez Gene)
ACSL4GeneProduct2182 (Entrez Gene)
ACSL5GeneProduct51703 (Entrez Gene)
ACSL6GeneProduct23305 (Entrez Gene)
ALAS1GeneProductENSG00000023330 (Ensembl)
AO (KE:345)
ATGLGeneProductENSG00000177666 (Ensembl)
AhR activationPathwayWP2586 (WikiPathways)
CAR activationPathwayWP2875 (WikiPathways)
CD36GeneProductENSG00000135218 (Ensembl)
CPT1AGeneProduct1374 (Entrez Gene)
CPT1AGeneProductENSG00000110090 (Ensembl)
CPT2GeneProduct1376 (Entrez Gene)
CYP1A1GeneProduct1543 (Entrez Gene)
CYP1A2GeneProduct1544 (Entrez Gene)
CYP1B1GeneProduct1545 (Entrez Gene)
CYP2A6GeneProduct1548 (Entrez Gene) cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2A6GeneProductENSG00000255974 (Ensembl)
CYP2B6GeneProduct1555 (Entrez Gene) cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP2C19GeneProduct1557 (Entrez Gene) cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProduct1559 (Entrez Gene) cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP3A4GeneProduct1576 (Entrez Gene) cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP3A5GeneProduct1577 (Entrez Gene) cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A5GeneProductENSG00000106258 (Ensembl)
CYP3A7GeneProductENSG00000160870 (Ensembl)
CYP4A11GeneProductENSG00000187048 (Ensembl)
CYP4F12GeneProductENSG00000186204 (Ensembl)
CYP7A1GeneProduct1581 (Entrez Gene) cytochrome P450, family 7, subfamily A, polypeptide 1 , is not affected in human
ChREBPGeneProductENSG00000009950 (Ensembl)
Cytoplasm displacement
DCIGeneProduct1632 (Entrez Gene)
DECR1GeneProduct1666 (Entrez Gene)
De novo FA synthesisPathwayWP357 (WikiPathways)
ECH1GeneProduct1891 (Entrez Gene)
ECHDC1GeneProduct55862 (Entrez Gene)
ECHDC2GeneProduct55268 (Entrez Gene)
ECHDC3GeneProduct79746 (Entrez Gene)
ECHS1GeneProduct1892 (Entrez Gene)
EHHADHGeneProduct1962 (Entrez Gene)
EHHADHGeneProductENSG00000113790 (Ensembl)
Endoplasmic reticulum stress
FA influx
FASNGeneProduct2194 (Entrez Gene)
FASPathwayWP357 (WikiPathways)
FOXA2GeneProductENSG00000125798 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
Fatty Liver cells
Fatty acid lysisPathwayWP3965 (WikiPathways)
GSTA2GeneProduct2939 (Entrez Gene) glutathione S-transferase alpha 2
GSTA2GeneProductENSG00000244067 (Ensembl)
HADHAGeneProduct3030 (Entrez Gene) similiar to: ECHA RAT
HADHSCGeneProduct3033 (Entrez Gene)
HMGCS2GeneProductENSG00000134240 (Ensembl)
HSD17B10GeneProductENSG00000072506 (Ensembl)
HSLGeneProductENSG00000079435 (Ensembl)
KE (KE:10102)
KE (KE:10106)
KE (KE:10110)
KE (KE:10201)GeneProduct
KE (KE:115)GeneProduct
KE (KE:116)GeneProduct
KE (KE:1214)
KE (KE:258)GeneProduct
KE (KE:264)GeneProduct
KE (KE:291)
KE (KE:466)
KE (KE:471)
KE

(KE:472)

KE

(KE:474)

KE (KE:54)GeneProduct
KE (KE:66)
KE (KE:860)
KE (KE:89)
LDLRGeneProductENSG00000130164 (Ensembl)
LXR activationPathwayWP2874 (WikiPathways)
Liver Steatosis
MECRGeneProduct51102 (Entrez Gene)
MIE (KE:10101)
MIE (KE:167)
MIE (KE:18)
MIE (KE:227)
MIE (KE:228)
MIE (KE:245
Mitochondrial Beta-oxidationPathwayWP368 (WikiPathways)
Mitochondrial disruption
NCOA1GeneProduct8648 (Entrez Gene) nuclear receptor coactivator 1
NCOA1GeneProductENSG00000084676 (Ensembl)
NCOA2GeneProduct10499 (Entrez Gene) nuclear receptor coactivator 2
NCOA2GeneProductENSG00000140396 (Ensembl)
NCOA3GeneProductENSG00000124151 (Ensembl)
NCOA6GeneProduct23054 (Entrez Gene) nuclear receptor coactivator 6
NRIP1GeneProductENSG00000180530 (Ensembl)
Nucleus distortion
PECRGeneProduct55825 (Entrez Gene)
PPARAGeneProductENSG00000186951 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PPARGC1AGeneProduct10891 (Entrez Gene) peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKAR1BGeneProductENSG00000188191 (Ensembl)
PRKAR2AGeneProductENSG00000114302 (Ensembl)
PRKAR2BGeneProductENSG00000005249 (Ensembl)
PSMC5GeneProductENSG00000087191 (Ensembl)
PXR activationPathwayWP2876 (WikiPathways)
SCDGeneProduct6319 (Entrez Gene)
SCDGeneProductENSG00000099194 (Ensembl)
SCP2GeneProduct6342 (Entrez Gene)
SLC25A20GeneProduct788 (Entrez Gene)
SLCO1B1GeneProductENSG00000134538 (Ensembl)
SMC1AGeneProduct8243 (Entrez Gene) structural maintenance of chromosomes 1A
SP1GeneProduct6667 (Entrez Gene) Sp1 transcription factor
SRCGeneProductENSG00000197122 (Ensembl)
SREBF1GeneProduct6720 (Entrez Gene) sterol regulatory element binding transcription factor 1
SREBP-1cGeneProductENSG00000072310 (Ensembl)
SRPX2GeneProductENSG00000102359 (Ensembl)
SULT1A1GeneProductENSG00000196502 (Ensembl) during fasting
SULT2A1GeneProductENSG00000105398 (Ensembl)
Triglyceride accumulation in Livercells
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)
p21cip1GeneProduct1026 (Entrez Gene)
p27Kip1GeneProduct1027 (Entrez Gene)

Annotated Interactions

No annotated interactions

Personal tools