Epilepsy Adverse Outcome Pathway (Homo sapiens)

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51223159146318292820710membranedepolarizationNMDA receptorcarbamazepinevoltage gatedsodium channelhippocampalhyperdepolarizationpresynapticneuron 1seizureGABAglutamateepilepsyRDXintracellularNa+2113252617301presynapticneuron 224114216intracellularCl+2219GABA-Areceptor activation8


Description

Adverse outcome pathway for epilepsy, originating from the AOPXplorer app for Cytoscape (http://apps.cytoscape.org/apps/aopxplorer). The pathway is also under development in the AOPWiki (https://aopwiki.org/aops/215).

Quality Tags

Ontology Terms

 

Bibliography

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  1. ''''; https://aopwiki.org/events/1357,
  2. ''''; https://aopwiki.org/events/1321,
  3. ''''; https://aopwiki.org/relationships/1452,
  4. ''''; https://aopwiki.org/events/1354,
  5. ''''; https://aopwiki.org/relationships/1456,
  6. ''''; https://aopwiki.org/relationships/1454,
  7. ''''; https://aopwiki.org/relationships/1460,
  8. ''''; https://aopwiki.org/events/1359,
  9. ''''; https://aopwiki.org/relationships/1455,
  10. ''''; https://aopwiki.org/relationships/1464,
  11. ''''; https://aopwiki.org/events/1352,
  12. ''''; https://aopwiki.org/relationships/1457,
  13. ''''; https://aopwiki.org/events/1362,
  14. ''''; https://aopwiki.org/relationships/1459,
  15. ''''; https://aopwiki.org/relationships/1461,
  16. ''''; https://aopwiki.org/events/1355,
  17. ''''; https://aopwiki.org/events/1361,
  18. ''''; https://aopwiki.org/relationships/1465,
  19. ''''; https://aopwiki.org/events/1322,
  20. ''''; https://aopwiki.org/relationships/1462,
  21. ''''; https://aopwiki.org/events/1351,
  22. ''''; https://aopwiki.org/events/1360,
  23. ''''; https://aopwiki.org/relationships/1463,
  24. ''''; https://aopwiki.org/events/1349,
  25. ''''; https://aopwiki.org/events/1350,
  26. ''''; https://aopwiki.org/events/1363,
  27. ''''; https://aopwiki.org/events/1358,
  28. ''''; https://aopwiki.org/relationships/1458,
  29. ''''; https://aopwiki.org/relationships/1453,
  30. ''''; https://aopwiki.org/events/1348,

History

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CompareRevisionActionTimeUserComment
96707view09:14, 28 March 2018Marvin M2Updated RDX node
96695view05:02, 28 March 2018EgonwRemoved comment accidentally added by/in PathVisio.
96694view03:22, 28 March 2018EgonwAlso added link to aopwiki as Comment.
96692view15:33, 27 March 2018Marvin M2Added references to all Key Events and Key Event Relationships to aopwiki.org
93720view12:03, 14 August 2017EgonwAdded a few identifiers, several from Wikidata as they refer more to concepts than specific genes or proteins.
92590view09:56, 19 June 2017EgonwRemoved whitespace in the labels.
92589view09:53, 19 June 2017EgonwModified description
92533view09:14, 14 June 2017EgonwOntology Term : 'disease pathway' added !
92532view09:13, 14 June 2017EgonwModified description
92531view19:02, 13 June 2017EgonwNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
GABA-A receptor activationProteinQ60147 (Wikidata)
GABAMetaboliteCHEBI:51374 (ChEBI)
NMDA receptorProteinQ414896 (Wikidata)
RDXMetaboliteCHEBI:24556 (ChEBI)
carbamazepineMetaboliteCHEBI:3387 (ChEBI)
epilepsyQ41571 (Wikidata)
glutamateMetaboliteCHEBI:18237 (ChEBI) https://aopwiki.org/events/1350
hippocampal hyperdepolarization
intracellular Cl+MetaboliteCHEBI:17996 (ChEBI)
intracellular Na+MetaboliteCHEBI:29101 (ChEBI)
membrane depolarization
presynaptic neuron 1Q2643251 (Wikidata)
presynaptic neuron 2Q2643251 (Wikidata)
seizureQ6279182 (Wikidata)
voltage gated sodium channelProtein

Annotated Interactions

No annotated interactions

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