Melanogenesis (Homo sapiens)

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SynergyEstrogenActiveTGF-BMelanogenesisPlasmintPAMITFTranexamic AcidPlasminogenPAI-1ActiveVEGFET-1SCF


Description

Melanogenesis is the process by which melanocytes produce melanin, a pigment found in the skin, eyes, and hair. Melanogenesis leads to a long-lasting pigmentation, which is in contrast to the pigmentation that originates from oxidation of already-existing melanin.

Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents.

Description adapted from Wikipedia and KEGG.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
96246view13:45, 2 March 2018Fehrhartconnected unconnected connections
96196view15:20, 25 February 2018EgonwModified description
96062view17:42, 15 February 2018KhanspersModified description
96061view17:40, 15 February 2018KhanspersModified description
96060view17:34, 15 February 2018KhanspersModified description
96059view17:32, 15 February 2018KhanspersModified description
92238view09:23, 15 May 2017AndraConnected the interactions
92192view10:36, 5 May 2017MarkifowlerAdded SCF
92109view13:25, 27 April 2017MarkifowlerAdded Tranexamic acid
92106view09:42, 27 April 2017MarkifowlerNew pathway
92105view09:19, 27 April 2017MarkifowlerNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Active TGF-BProtein
Active VEGFProtein
ET-1Protein
Estrogen Protein
MITFProtein
MelanogenesisPathway
PAI-1Protein
PlasminMetaboliteCHEBI:53373 (ChEBI)
PlasminogenProteinP00747 (Uniprot-TrEMBL)
SCFProtein
Tranexamic AcidProtein
tPAProtein

Annotated Interactions

No annotated interactions

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