Role of Osx and miRNAs in tooth development (Homo sapiens)

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1CementumCementoblastlet-7 miRNAsStimulationMIR145RUNX2MIR29Clithium chlorideOSXKLF4DMP1DSPPBMP7NOTCH1NOTCH2NOTCH3NOTCH4ALPDKK1SOSTTCF-1CTNNB1MIR338MIR32MIR586MIR885MIR29AMIR34AMIRLET7A1MIR143MIR204MIR211DentinOdontoblastMIRLET7A2MIRLET7CMIRLET7DMIRLET7EMIRLET7F1MIRLET7F2MIRLET7GMIRLET7IMIR29B1MIR29B2mir-29 miRNAsInhibitionCrosstalkLegendBACCCCCCA, B, CCorresponds to pathway description


Description

Role of Osx and certain miRNAs in tooth development.

A – The role of Osx in dentinogenesis is shown by its regulation on Dspp.

B – Osx regulates the differentiation of cementoblasts through Wnt-β-catenin pathway.

C – Fine-tuning role of miRNA in tooth development.

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Ontology Terms

 

Bibliography

  1. Wang C, Liao H, Cao Z; ''Role of Osterix and MicroRNAs in Bone Formation and Tooth Development.''; Med Sci Monit, 2016 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
105314view22:42, 29 July 2019AriuttaHGNC -> HGNC Accession number.
91525view22:51, 8 March 2017KhanspersOntology Term : 'signaling pathway pertinent to development' added !
91524view22:50, 8 March 2017KhanspersOntology Term : 'odontoblast' added !
91523view22:50, 8 March 2017KhanspersOntology Term : 'cementoblast' added !
91522view22:49, 8 March 2017KhanspersModified description
91521view22:49, 8 March 2017KhanspersModified description
91520view22:49, 8 March 2017Khanspersadded specific areas corresponding to description
91519view22:44, 8 March 2017KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ALPGeneProductENSG00000162551 (Ensembl)
BMP7GeneProductENSG00000101144 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DMP1GeneProductENSG00000152592 (Ensembl)
DSPPGeneProductENSG00000152591 (Ensembl)
KLF4GeneProductENSG00000136826 (Ensembl)
MIR143GeneProductMI0000459 (miRBase Sequence)
MIR145GeneProductENSG00000276365 (Ensembl)
MIR204GeneProductENSG00000207935 (Ensembl)
MIR211GeneProductENSG00000207702 (Ensembl)
MIR29AGeneProductENSG00000226380 (Ensembl)
MIR29B1GeneProduct407024 (Entrez Gene)
MIR29B2GeneProduct31620 (HGNC Accession number)
MIR29CRna31621 (HGNC Accession number)
MIR32GeneProductENSG00000207698 (Ensembl)
MIR338GeneProductENSG00000283604 (Ensembl)
MIR34AGeneProductENSG00000228526 (Ensembl)
MIR586GeneProductENSG00000207769 (Ensembl)
MIR885GeneProductENSG00000216135 (Ensembl)
MIRLET7A1GeneProductENSG00000199165 (Ensembl)
MIRLET7A2GeneProductENSG00000198975 (Ensembl)
MIRLET7CGeneProductENSG00000199030 (Ensembl)
MIRLET7DGeneProductENSG00000199133 (Ensembl)
MIRLET7EGeneProductENSG00000198972 (Ensembl)
MIRLET7F1GeneProductENSG00000199072 (Ensembl)
MIRLET7F2GeneProductENSG00000208012 (Ensembl)
MIRLET7GGeneProductENSG00000199150 (Ensembl)
MIRLET7IGeneProductENSG00000199179 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
NOTCH3GeneProductENSG00000074181 (Ensembl)
NOTCH4GeneProductENSG00000204301 (Ensembl)
OSXGeneProductENSG00000170374 (Ensembl)
RUNX2GeneProductENSG00000124813 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
TCF-1GeneProductENSG00000135100 (Ensembl)
lithium chlorideMetaboliteCHEBI:48607 (ChEBI)

Annotated Interactions

No annotated interactions

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