Id Signaling Pathway (Rattus norvegicus)

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Reaction through unknown mechanisms/moleculesInhibitionPhosphorylationDephosphorylationDeacetylationDDPNucleusAccession Number: NetPath 5; cellmap:5MTCY -> NURecruitmentDActivationAutophosphorylationPalmitoylationExtracellularEnzyme complexGOGolgi apparatusReceptorDGlycosylationNUCytoplasmDUbiquitinationControlDesumoylationEndosomeProteins in a complex interactionENID Gene RegulationProteolytic cleavageDemethylationDeubiquitinationEndoplasmic reticulumLigandSumoylationMolecule in the PathwayTranslocationMolecular association(Protein-protein interaction)PECPlasma membraneAcetylationMitochondriaCYPMethylationERPMPax8Ctnnb1Smad5Pax2Bmp6Acvrl1Atf3Smad4TertElk1Bmp2Elk4Irs1Id2Tcfe2aId4Id3Bmpr2Smad3Ccna2LCKMyf5Myf6PI3KSmad1Igf1Elk3Rb1Srebf1Flt1Id1RelaHes1KDRMscSmad5Igf1rRASSmad3ERKId2Gene SymbolMyogIFI16PAX5MAPKCdk2Smad4NgfTgif1Smad1Tcf12EgfCcne1Cd40lgAtf3TCRMyod1Rbl2Rbl1Psmd4LOC679869VegfaNfkb1


Inhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA binding capacity. This family of proteins is comprised of IDs 1, 2, 3 and 4. They can be stimulated by ligands such as the Vascular Endothelial Growth Factor (VEGF), TGF beta and the T cell receptor. Source: NetPath


GenMAPP notes 
NetPath 5; cellmap:5 - Id Signaling Pathway

The Id Signaling Pathway was kindly reviewed by Jonathan Perk and other members of Robert Benezra’s lab. This cancer signaling pathway is available at Cancer Cell Map ( and NetPath ( and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (, PandeyLab at Johns Hopkins University ( and Institute of Bioinformatics ( If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks;
This pathway was inferred from Homo sapiens pathway WP53(r20789) with a 84% conversion rate.

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Ontology Terms



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69409view19:01, 8 July 2013MaintBotUpdated to 2013 gpml schema
67358view10:41, 26 June 2013Christine ChichesterOntology Term : 'Inhibitor of DNA binding signaling pathway' added !
41731view02:39, 2 March 2011MaintBotRemoved redundant pathway information and comments
35748view23:58, 12 February 2010AlexanderPico
34106view19:21, 9 December 2009MaintBotAutomatic update of empty xrefs
31446view21:08, 13 August 2009MaintBotFixed text labels
30995view00:57, 30 July 2009MaintBotConverted from Homo sapiens
21518view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Id NetPath 5]] moved to [[Pathway:WP397]]: Moved to stable identifier
8156view13:46, 7 January 2008MaintBot[[Pathway:Rat:Id NetPath 5]] moved to [[Pathway:Rattus norvegicus:Id NetPath 5]]: Renaming species
7698view16:10, 18 December 2007MaintBotfixed category names
7264view12:41, 4 November 2007MaintBotAdded categories to GPML
6566view22:20, 22 May 2007A.Pandeygpml file for [[Rat:Id_NetPath_5]]

External references


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NameTypeDatabase referenceComment
Acvrl1GeneProduct25237 (Entrez Gene)
Atf3GeneProduct25389 (Entrez Gene)
Bmp2GeneProduct29373 (Entrez Gene)
Bmp6GeneProduct25644 (Entrez Gene)
Bmpr2GeneProduct140590 (Entrez Gene)
Ccna2GeneProduct114494 (Entrez Gene)
Ccne1GeneProduct25729 (Entrez Gene)
Cd40lgGeneProduct84349 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene)
Ctnnb1GeneProduct84353 (Entrez Gene)
EgfGeneProduct25313 (Entrez Gene)
Elk1GeneProduct314436 (Entrez Gene)
Elk3GeneProduct362871 (Entrez Gene)
Elk4GeneProduct304786 (Entrez Gene)
Flt1GeneProduct54251 (Entrez Gene)
Gene SymbolGeneProduct
Hes1GeneProduct29577 (Entrez Gene)
Id1GeneProduct25261 (Entrez Gene)
Id2GeneProduct25587 (Entrez Gene)
Id3GeneProduct25585 (Entrez Gene)
Id4GeneProduct291023 (Entrez Gene)
Igf1GeneProduct24482 (Entrez Gene)
Igf1rGeneProduct25718 (Entrez Gene)
Irs1GeneProduct25467 (Entrez Gene)
KDRGeneProduct25589 (Entrez Gene)
LCKGeneProduct313050 (Entrez Gene)
LOC679869GeneProduct679869 (Entrez Gene)
MscGeneProduct312897 (Entrez Gene)
Myf5GeneProduct299766 (Entrez Gene)
Myf6GeneProduct25714 (Entrez Gene)
Myod1GeneProduct337868 (Entrez Gene)
MyogGeneProduct29148 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
NgfGeneProduct310738 (Entrez Gene)
Pax2GeneProduct293992 (Entrez Gene)
Pax8GeneProduct81819 (Entrez Gene)
Psmd4GeneProduct83499 (Entrez Gene)
Rb1GeneProduct24708 (Entrez Gene)
Rbl1GeneProduct680111 (Entrez Gene)
Rbl2GeneProduct81758 (Entrez Gene)
RelaGeneProduct309165 (Entrez Gene)
Smad1GeneProduct25671 (Entrez Gene)
Smad3GeneProduct25631 (Entrez Gene)
Smad4GeneProduct50554 (Entrez Gene)
Smad5GeneProduct59328 (Entrez Gene)
Srebf1GeneProduct78968 (Entrez Gene)
Tcf12GeneProduct25720 (Entrez Gene)
Tcfe2aGeneProduct171046 (Entrez Gene)
TertGeneProduct301965 (Entrez Gene)
Tgif1GeneProduct316742 (Entrez Gene)
VegfaGeneProduct83785 (Entrez Gene)

Annotated Interactions

No annotated interactions
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