Lipid Metabolism Pathway (Homo sapiens)

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Lipid Droplet Mitochondria213rate limiting stepAMPK subunit αLipogenesisAKTGlycerolipidmetabolismFatty acidelongationPLIN1HILPDAGlycerophospholipidmetabolismAKT3PNPLA2LIPEACACAPRKAG3PDHA1PRKAG1ABHD5BCAABCKDHAFASNACLYPRKAA1ACSS2PRKAB2AKT2PRKAB1PRKAA2AKT1PRKAG2ACSBG1BCFAPyruvateAcetyl-CoA(mit)CitrateAcetyl-CoA(cyt)Malonyl-CoAPalimitatePalimitate-CoAAcetateLipolysisTAGDAGMAGFree fatty acidsAMPK subunit βAMPK subunit γPKA regulatory subunit type IPRKACGPRKACAPRKAR1APRKAR2BPRKAR2APRKAR1BPRKACBPKA regulatory subunit type IIPKA catalytic subunit


Description

Lipid metabolism is the break down or storage of fats for energy; these fats are obtained from consuming food and absorbing them or they are synthesized by an animal's liver. Lipid metabolism does exist in plants, though the processes differ in some ways when compared to animals. Lipogenesis is the process of synthesizing these fats. Lipid metabolism often begins with hydrolysis, which occurs when a chemical breaks down as a reaction to coming in contact with water. Since lipids (fats) are hydrophobic, hydrolysis in lipid metabolism occurs in the cytoplasm which ends up creating glycerol and fatty acids. Due to the hydrophobic nature of lipids they require special transport proteins known as lipoproteins, which are hydrophilic. Lipoproteins are categorized by their density levels. The varying densities between the types of lipoproteins are characteristic to what type of fats they transport. A number of these lipoproteins are synthesized in the liver, but not all of them originate from this organ.

Description source: Wikipedia

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Zhang X, Saarinen AM, Hitosugi T, Wang Z, Wang L, Ho TH, Liu J; ''Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia.''; Elife, 2017 PubMed Europe PMC
  2. Asfa AS, Qiu B, Wee S, Choi H, Gunaratne J, Tergaonkar V; ''Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.''; Sci Rep, 2016 PubMed Europe PMC
  3. Grahn TH, Zhang Y, Lee MJ, Sommer AG, Mostoslavsky G, Fried SK, Greenberg AS, Puri V; ''FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes.''; Biochem Biophys Res Commun, 2013 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106630view20:55, 12 September 2019KhanspersModified description
105636view05:05, 10 August 2019KhanspersModified description
96169view12:30, 22 February 2018Mkutmonadded link from PLIN1 to HSL
96168view12:20, 22 February 2018MkutmonUpdated layout and complexes
95533view09:16, 21 December 2017EgonwAdded a recent protein found that inhibits ATGL.
94914view00:11, 13 October 2017KhanspersModified description
94741view15:09, 5 October 2017Mkutmonfix unconnected line
91544view06:35, 10 March 2017EgonwAdded the last few metabolite IDs.
91543view20:15, 9 March 2017EgonwAdded a few metabolite IDs.
91542view18:53, 9 March 2017EgonwTypo.
91437view20:06, 24 February 2017SusanOntology Term : 'lipid metabolic pathway' added !
91436view20:05, 24 February 2017SusanOntology Term : 'obesity' added !
91435view20:04, 24 February 2017SusanOntology Term : 'white fat cell' added !
91400view08:03, 20 February 2017MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABHD5GeneProductENSG00000011198 (Ensembl) P:S81
ACACAGeneProductENSG00000278540 (Ensembl) P:S23,P:S29,P:S79,P:S47,P:S49
ACLYGeneProductENSG00000131473 (Ensembl) P:S455,P:S653,P:S1090
ACSBG1GeneProductENSG00000103740 (Ensembl) P:S79
ACSS2GeneProductENSG00000131069 (Ensembl) P:S30,P:S263,P:S267
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
AcetateMetaboliteCHEBI:30089 (ChEBI)
Acetyl-CoA(cyt)MetaboliteCHEBI:15351 (ChEBI)
Acetyl-CoA(mit)MetaboliteCHEBI:15351 (ChEBI)
BCAAMetaboliteCHEBI:22918 (ChEBI) Branched-chain amino acid
BCFAMetaboliteCHEBI:35819 (ChEBI) Branched-chain fatty acid
BCKDHAGeneProductENSG00000248098 (Ensembl)
CitrateMetaboliteCHEBI:35804 (ChEBI)
DAGMetaboliteCHEBI:18035 (ChEBI) Diglyceride
FASNGeneProductENSG00000169710 (Ensembl)
Fatty acid elongationPathway
Free fatty acidsMetaboliteCHEBI:35366 (ChEBI)
Glycerolipid metabolismPathway
Glycerophospholipid metabolismPathway
HILPDAGeneProductENSG00000135245 (Ensembl)
LIPEGeneProductENSG00000079435 (Ensembl)
  • HSL
  • P:S964
MAGMetaboliteCHEBI:17408 (ChEBI) Monoglyceride
Malonyl-CoAMetaboliteCHEBI:15531 (ChEBI)
PDHA1GeneProductENSG00000131828 (Ensembl)
PLIN1GeneProductENSG00000166819 (Ensembl) PeriA
PNPLA2GeneProductENSG00000177666 (Ensembl) ATGL
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKAR1BGeneProductENSG00000188191 (Ensembl)
PRKAR2AGeneProductENSG00000114302 (Ensembl)
PRKAR2BGeneProductENSG00000005249 (Ensembl)
Palimitate-CoAMetaboliteCHEBI:15525 (ChEBI)
PalimitateMetaboliteCHEBI:15756 (ChEBI)
PyruvateMetaboliteCHEBI:15361 (ChEBI)
TAGMetaboliteCHEBI:17855 (ChEBI) Triglyceride

Annotated Interactions

No annotated interactions

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