Copper homeostasis (Caenorhabditis elegans)

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11Hypodermal cellIntestinal cellGolgiNeuronGut granules1Intestinal lumenPseudocoelomCUC-1CuCuCuIntestinal cellHypodermal cellIntestinal cellCUA-1.11CuCuUnknown copper importerelementalcopperCuCUA-1.11CUA-1.21CUA-1.11CuCuCUA-1.11CuCUA-1.21Cu1


Description

Adapted from figure 7 from Chun et al (see Bibliography). Cu homeostasis in worms is maintained by distinctly localized intestinal CUA-1 isoforms. A model of Cu homeostasis in C. elegans is shown. Dietary Cu ions are transported from the lumen of the intestine to the enterocytes by an unidentified Cu importer, and CUC-1 delivers Cu to CUA-1. Under basal Cu or Cu-deficient conditions, CUA-1.1 isoform localizes to the basolateral membrane and Golgi to either export Cu ions to peripheral tissues, or to direct Cu into the secretory pathway. CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. CUA-1.1 is redistributed to the gut-granule membranes in response to elevated Cu levels in order to promote Cu detoxification in C. elegans."

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Ontology Terms

 

Bibliography

  1. Chun H, Sharma AK, Lee J, Chan J, Jia S, Kim BE; ''The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans.''; J Biol Chem, 2017 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
92322view23:56, 22 May 2017Khanspersbolding of labels and decrease arrow thickness to enhance readability
91980view20:22, 10 April 2017MaintBotfixed groups, added oval to copper, moved compartment labels for visibility
91979view20:14, 10 April 2017KhanspersModified description
91921view04:46, 6 April 2017MaintBotconnected line
91354view21:45, 6 February 2017KyookOntology Term : 'intestinal epithelial cell' added !
91353view21:43, 6 February 2017KyookOntology Term : 'copper homeostasis pathway' added !
91352view21:42, 6 February 2017Kyookchanged copper input label
91350view21:25, 6 February 2017MaintBotmoved comment to description
91349view21:25, 6 February 2017MaintBotModified description
91348view21:24, 6 February 2017MaintBotNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
CUA-1.1GeneProductY76A2A.2 (WormBase)
CUA-1.2GeneProductY76A2A.2 (WormBase) "CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. "
CUC-1GeneProductZK652.11 (WormBase)
CuMetaboliteCHEBI:37404 (ChEBI)
elemental copperMetaboliteCHEBI:37404 (ChEBI)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
CUA-1.1ArrowWP:CE26305 (WormBase) "CUA-1.1 is redistributed to the gut-granule membranes in response to elevated Cu levels in order to promote Cu detoxification in C. elegans."
CUA-1.2ArrowWP:CE19271 (WormBase) "CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions." Evidence: "Confocal images of transgenic animals [Pvha-6::CUA-1.2::GFP::unc-54 3’UTR] expressing CUA-1.2::GFP in the intestine in the presence of 50 μM of supplemental Cu or BCS."
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