One carbon metabolism and related pathways (Homo sapiens)

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Bile acid biosynthesisOxidative stress enzymesH2OH2O2DHFR2TYMSPEMTFolic acid5-Methyltetrahydrofolic acidGAD2TaurineL-CystathionineSOD3L-MethioninePhosphatidylcholinesGlutamateTaurochenodesoxycholic acidTotal PhospholipidsGlycineGCLMCTHBAATHypotaurineAHCYL1DNMT3ASarcosineS-AdenosylmethionineBetaineSARDHCHDHGCLCNADPGlutathione (GSH)CHKACDO1L-SerineGlutathione disulfide (GSSG)L-SerineGPX5GAD1HomocysteineCEPT1MTRPhosphatidylethanolamineCBSLGPX7PCYT1BETNK2gamma-GlutamylcysteineGSSCholinePCYT1ASHMT2DimethylglycineMTHFRCDP-EthanolamineETNK1PLD1GSRPCYT2CSADS-Adenosylhomocysteine5-oxoprolineCHPT1L-CysteineBHMTGlycineSOD1GPX410-formyldihydrofolateMAT2AGNMTBHMT2CHKB5,10-Methenyltetrahydrofolic acidNADPHPhosphocholineDNM1GPX23-SulfinoalanineDMGDHMAT1ASOD2GPX3Taurocholic acidEthanolamineO-PhosphoethanolamineSHMT1GPX1Tetrahydrofolic acidCDP-cholineGPX62-oxobutanoate(S)-2-Aminobutanoategamma-L-Glutamyl-L-2-aminobutyrateOphthalmateBCAT1AGXT2GCLCGSSBCAT2GCLM


Description

This pathway shows the carbon metabolism over grey and related pathways around it. Source [1]

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway WP1770_96326 with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
102896view10:25, 27 January 2019EgonwReplaced two PubChem SID with CID identifiers.
96353view17:03, 9 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
96327view09:30, 8 March 2018MkutmonUpdated homology conversion
96235view13:30, 1 March 2018DeSlModified description
96234view13:30, 1 March 2018DeSlRemoved licence number and last modified part.
94312view12:05, 1 September 2017Marvin M2Connected unconnected lines
94206view21:13, 25 August 2017DeSlAdded ID for phosphocholine
93078view09:01, 28 July 2017ElisaFixed unconnected interactions (added anchors to lines)
93018view09:37, 25 July 2017DeSlAdded small sidebrach from L-Cystationine to Ophthalmate.
91096view01:13, 4 January 2017Khanspersconnected interactions
90808view18:21, 14 December 2016KhanspersOntology Term : 'folate mediated one-carbon metabolic pathway' added !
90807view18:20, 14 December 2016KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(S)-2-AminobutanoateMetaboliteCHEBI:35619 (ChEBI)
10-formyldihydrofolateMetaboliteHMDB06485 (HMDB)
2-oxobutanoateMetabolite16763 (ChEBI)
3-SulfinoalanineMetaboliteC00606 (KEGG Compound)
5,10-Methenyltetrahydrofolic acidMetaboliteC00445 (KEGG Compound)
5-Methyltetrahydrofolic acidMetaboliteC00440 (KEGG Compound)
5-oxoprolineMetaboliteC01879 (KEGG Compound)
AGXT2GeneProductENSG00000113492 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000089678
AHCYL1GeneProductENSG00000168710 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:229709
BAATGeneProductENSG00000136881 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12012
BCAT1GeneProductENSG00000060982 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030268
BCAT2GeneProductENSG00000105552 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030826
BHMT2GeneProductENSG00000132840 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64918
BHMTGeneProductENSG00000145692 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12116
BetaineMetaboliteC00719 (KEGG Compound)
CBSLGeneProductENSG00000274276 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12411
CDO1GeneProductENSG00000129596 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12583
CDP-EthanolamineMetaboliteC00570 (KEGG Compound)
CDP-cholineMetaboliteC00307 (KEGG Compound)
CEPT1GeneProductENSG00000134255 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:99712
CHDHGeneProductENSG00000016391 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218865
CHKAGeneProductENSG00000110721 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12660
CHKBGeneProductENSG00000100288 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651
CHPT1GeneProductENSG00000111666 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862
CSADGeneProductENSG00000139631 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:246277
CTHGeneProductENSG00000116761 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107869
CholineMetaboliteC00114 (KEGG Compound)
DHFR2GeneProductENSG00000178700 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13361
DMGDHGeneProductENSG00000132837 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74129
DNM1GeneProductENSG00000106976 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13429
DNMT3AGeneProductENSG00000119772 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13435
DimethylglycineMetaboliteC01026 (KEGG Compound)
ETNK1GeneProductENSG00000139163 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320
ETNK2GeneProductENSG00000143845 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:214253
EthanolamineMetaboliteC00189 (KEGG Compound)
Folic acidMetaboliteC00504 (KEGG Compound)
GAD1GeneProductENSG00000128683 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14415
GAD2GeneProductENSG00000136750 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14417
GCLCGeneProductENSG00000001084 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032350
GCLMGeneProductENSG00000023909 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028124
GNMTGeneProductENSG00000124713 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14711
GPX1GeneProductENSG00000233276 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14775
GPX2GeneProductENSG00000176153 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14776
GPX3GeneProductENSG00000211445 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14778
GPX4GeneProductENSG00000167468 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:625249
GPX5GeneProductENSG00000224586 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14780
GPX6GeneProductENSG00000198704 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75512
GPX7GeneProductENSG00000116157 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67305
GSRGeneProductENSG00000104687 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14782
GSSGeneProductENSG00000100983 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027610
GlutamateMetaboliteC00217 (KEGG Compound)
Glutathione (GSH)MetaboliteC00051 (KEGG Compound)
Glutathione disulfide (GSSG)MetaboliteC00127 (KEGG Compound)
GlycineMetaboliteC00037 (KEGG Compound)
HomocysteineMetaboliteC05330 (KEGG Compound)
HypotaurineMetaboliteC00519 (KEGG Compound)
L-CystathionineMetaboliteC02291 (KEGG Compound)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-MethionineMetaboliteHMDB00696 (HMDB)
L-SerineMetaboliteC00065 (KEGG Compound)
MAT1AGeneProductENSG00000151224 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11720
MAT2AGeneProductENSG00000168906 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:232087
MTHFRGeneProductENSG00000177000 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17769
MTRGeneProductENSG00000116984 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:238505
NADPMetaboliteC00006 (KEGG Compound)
NADPHMetaboliteC00005 (KEGG Compound)
O-PhosphoethanolamineMetaboliteC00346 (KEGG Compound)
OphthalmateMetabolite7018721 (PubChem-compound)
PCYT1AGeneProductENSG00000161217 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026
PCYT1BGeneProductENSG00000102230 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:236899
PCYT2GeneProductENSG00000185813 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671
PEMTGeneProductENSG00000133027 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18618
PLD1GeneProductENSG00000075651 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18805
PhosphatidylcholinesMetabolite8002-43-5 (CAS)
PhosphatidylethanolamineMetaboliteC00350 (KEGG Compound)
PhosphocholineMetaboliteCHEBI:18132 (ChEBI)
S-AdenosylhomocysteineMetaboliteC00021 (KEGG Compound)
S-AdenosylmethionineMetaboliteC00019 (KEGG Compound)
SARDHGeneProductENSG00000123453 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192166
SHMT1GeneProductENSG00000176974 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20425
SHMT2GeneProductENSG00000182199 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108037
SOD1GeneProductENSG00000142168 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20655
SOD2GeneProductENSG00000112096 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20656
SOD3GeneProductENSG00000109610 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20657
SarcosineMetaboliteC00213 (KEGG Compound)
TYMSGeneProductENSG00000176890 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22171
TaurineMetaboliteC00245 (KEGG Compound)
Taurochenodesoxycholic acidMetaboliteC05465 (KEGG Compound)
Taurocholic acidMetaboliteC05122 (KEGG Compound)
Tetrahydrofolic acidMetaboliteC00101 (KEGG Compound)
Total PhospholipidsMetabolite16247 (ChEBI)
gamma-GlutamylcysteineMetaboliteC00669 (KEGG Compound)
gamma-L-Glutamyl-L-2-aminobutyrateMetabolite7014903 (PubChem-compound)

Annotated Interactions

No annotated interactions
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