BMP Signaling Pathway in Eyelid Development (Homo sapiens)

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1Meibomian GlandConjunctival Cell FateEyelid ClosurePeriderm MigrationEyelid ClosureConjunctiva Proliferation andPrecocious DifferentiationTranslocation intoNucleusTransdifferentiation of MeibomianGland into Hair FollicleMAP3K1DKK2SMAD5FGF10BMP4SFRP1SHHBmp Canonical SignalingFOXC1SMAD4FOXC2TGFANOTCH1FGFR2Wnt Canonical SignalingJUNMAPK3INHBBSMAD1EGFRMAPK9PITX2


Description

The signaling pathways involved in eyelid development are displayed with interactions that are known (solid arrows) and proposed (dotted arrows). The four main pathways shown are activated by Fgf10 and regulate key processes, but also interact with each other. The first pathway is a proposed promotion of sfrp1 which inhibits Wnt that regulates the Meibomian Gland. The Wnt pathway also activates pitx2 and begins the proposed pathway to eyelid closure. The second pathway begins with Fgfr2 activating Bmp4, a protein that may also be regulated by Shh, and continuing through a protein chain to regulate conjunctival cell fate. In this pathway Bmp also inhibits transdifferentiation of Meibomian Gland into a hair follicle, conjunctiva proliferation, and precocious differentiation. The last two pathways are linked to the regulation of eyelid closure through a cascade of protein activation and is further promoted by Bmp through stimulation of phosphorylated c-Jun. This pathway is based on figure 10B from Huang et al. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "BMP Signaling Pathway in Eyelid Development", WP3663 revision 90081, with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Huang J, Dattilo LK, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC; ''FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.''; Development, 2009 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106309view17:46, 20 August 2019KhanspersModified description
105671view18:40, 12 August 2019EgonwAnd now the human one. The textual ID was mentioned mouse, so added that first :/
105670view18:38, 12 August 2019EgonwAdded WP identifier.
105540view06:06, 9 August 2019KhanspersModified description
90735view23:23, 13 December 2016Khanspersupdated source pathway
90734view23:20, 13 December 2016KhanspersOntology Term : 'signaling pathway pertinent to development' added !
90733view23:19, 13 December 2016KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BMP4GeneProductENSG00000125378 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021835
Bmp Canonical SignalingPathwayWP339 (WikiPathways) Identifier Not Found
DKK2GeneProductENSG00000155011 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028031
EGFRGeneProductENSG00000146648 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020122
FGF10GeneProductENSG00000070193 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021732
FGFR2GeneProductENSG00000066468 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030849
FOXC1GeneProductENSG00000054598 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000050295
FOXC2GeneProductENSG00000176692 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046714
INHBBGeneProductENSG00000163083 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037035
JUNGeneProductENSG00000177606 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052684
MAP3K1GeneProductENSG00000095015 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021754
MAPK3GeneProductENSG00000102882 (Ensembl)
  • ERK Not Specified
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000063065
MAPK9GeneProductENSG00000050748 (Ensembl)
  • JNK Not Specified
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020366
NOTCH1GeneProductENSG00000148400 (Ensembl)
  • Notch Not Specified
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026923
PITX2GeneProductENSG00000164093 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028023
SFRP1GeneProductENSG00000104332 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031548
SHHGeneProductENSG00000164690 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002633
SMAD1GeneProductENSG00000170365 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031681
SMAD4GeneProductENSG00000141646 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024515
SMAD5GeneProductENSG00000113658 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021540
TGFAGeneProductENSG00000163235 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029999
Wnt Canonical SignalingPathwayWP428 (WikiPathways)

Annotated Interactions

No annotated interactions
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