Angiopoietin Like Protein 8 Regulatory Pathway (Homo sapiens)

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3618, 2612, 206, 2555, 28527636336347, 3526276, 737371811, 1721, 28, 2926, 32272342386272214276, 252223169, 10, 1937, 447, 432222149, 10, 1941622341824, 3042313418, 262336mTORC1Erk SignalTransduction PathwayPI 3-Kinase isoformsActivationLegendT3Ampk isoformsHepatocyteInhibitionp70 S6 KinasesGlucose UptakeInsulin Receptor SubstratesPancreatic Beta-cell proliferationInsulinIRS2PIK3CBPP2APIK3C2ACell GrowthDifferentiationG-6-PPIK3CAIRS4mTORmlst8GSglycogenRASPIK3R4SEST3RHEBF-2,6-P2RAF1PIK3R1Glycolysis-GluconeogenesisPPARalphaInsulin Signaling Pathway LPLTriacylglyceride SynthesisRaptorGLUT4mTORPEPCKPI(4,5)P2LXRPIK3R2Autophagy SignalingPIK3R3CIP42G6PCRPS6KB2SOS2amino acidsGlucoseRPS6KB1IRS1GlycogenesisGRB2GLUT1PIK3C3PIK3CGFBPSREBP1a-c AMPKPathwayCD45+ hematopoietic- derived cell proliferation SOS1GCKINSRProtein synthesis and Translation RegulationPTPExo70TSC1ChrebpPIK3C2GPIK3CDTSC2SREBP PathwayX-5-PSREBP2SIN1RictorPI(3,4,5)P324116DIO2RXRATHRATHRBSLC16A2SLCO1C1T3T4RXRAANGPTL8T3 and T4 intracelullar uptakeSHC2SHC3SHC1GSK3AGSK3BPDKPKB/Akt isoformsAKT1AKT2pT308pT308EIF4EEIF4EBP1mlst8mTORSIN1pRictormlst8mTORC2FOXO1AFOXO3AmTORC2INSRCAP1CBLFLOT1FLOT2CRKRAPGEF1RHOQTransport of GLUT4 Transporters toPlasma MembraneRictorRXRA1, 8ABCG84FASNABCG540CYP3A4440CYP7A140CYP2B640LXR target genesDrug and steroidmetabolism13Multi-drugresistancelipogenesisSCDTranscriptionfactorsMEK/MAP Kinasesp90 Rsk KinasesMAP2K1MAP3K7MAPK14MAPK1MAP2K2RPS6KA5MAP3K2MAP3K6MAPK8MAP4K1MAP3K11MAP4K3MAPK10RPS6KA6MAP2K7MAP3K4MAP3K1MAP3K12MAPK4RPS6KA4MAPK11MAP4K5MAPK6MAP4K4MAPK3MAP3K14MAPK12MAP2K5MAP2K4MAPK13RPS6KA1RPS6KA2MAP3K5RPS6KA3MAPK9MAPK7MAP3K3MAP3K9MAP3K8MAP2K6MAP3K13MAP4K2MAP2K3MAP3K10MINK1PI(3,4,5)P3PKB/Akt isoformsAKT1pS473AKT2pT308pT308pS473CBLCCBLBFOXO1AFOXO3AInsulinINSRLXR target genes13CatalysisInsulin Signaling Pathway Undefined MechanismT4Activation from within the PathwayAMPKy3AMPKa1AMPKy2AMPKy1AMPKb2AMPKb1AMPKa2Ampk isoforms1711, 17


Description

The hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated signaling events of insulin signaling in the liver. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
112155view17:57, 29 September 2020Khanspersremoved extraneous text from comments
110713view14:55, 28 May 2020Marvin M2changed unknown type to metabolite with chebi ID
106761view13:24, 17 September 2019MaintBotHMDB identifier normalization
106297view17:42, 20 August 2019KhanspersModified description
105529view06:01, 9 August 2019KhanspersModified description
94801view23:35, 5 October 2017AlexanderPicoConverted lines, removed nested groups and connected interactions
93137view15:19, 31 July 2017SiddiqaANGPTL8 role in CD45+ hematopoietic-derived cell proliferation
92444view06:37, 6 June 2017SiddiqaInteractions present exclusively in rat/mouse updated.
92359view08:00, 30 May 2017SusanLegend adapted
90629view14:45, 2 December 2016EgonwNo mim-conversion on gene-gene interactions.
90628view14:41, 2 December 2016EgonwRemoved type info from Entrez Gene ID.
90627view14:09, 2 December 2016EgonwUppercased c in KEGG identifier.
90610view22:11, 1 December 2016KhanspersModified description
90604view10:18, 1 December 2016Elisasolved unconnected lines
90499view14:52, 18 November 2016SusanOntology Term : 'insulin signaling pathway' added !
90498view14:51, 18 November 2016SusanModified description
90497view14:48, 18 November 2016SusanOntology Term : 'regulatory pathway' added !
90463view12:44, 17 November 2016SiddiqaModified title
90461view12:40, 17 November 2016SiddiqaAdded AUthor List
90460view11:58, 17 November 2016SiddiqaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AMPK PathwayPathwayWP1403 (WikiPathways)
ABCG5GeneProductENSG00000138075 (Ensembl)
ABCG8GeneProductENSG00000143921 (Ensembl)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AMPKa1GeneProduct5562 (Entrez Gene)
AMPKa2GeneProduct5563 (Entrez Gene)
AMPKb1GeneProduct5564 (Entrez Gene)
AMPKb2GeneProduct5565 (Entrez Gene)
AMPKy1GeneProduct5571 (Entrez Gene)
AMPKy2GeneProduct51422 (Entrez Gene)
AMPKy3GeneProduct53632 (Entrez Gene)
ANGPTL8GeneProduct55908 (Entrez Gene)
  • synonyms: RIFL; TD26; PRO1185; PVPA599; C19orf80
  • Type your comment here
Autophagy SignalingPathway
CAP1GeneProduct10487 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CBLCGeneProduct23624 (Entrez Gene)
CD45+ hematopoietic-
  derived cell 
proliferation
PathwayWP2849 (WikiPathways)
CIP42GeneProduct9322 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP7A1GeneProductENSG00000167910 (Ensembl) is not affected in human
Cell Growth DifferentiationPathwayWP2029 (WikiPathways)
ChrebpGeneProduct51085 (Entrez Gene)
DIO2GeneProduct1734 (Entrez Gene)
Drug and steroid metabolismPathway
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
Exo70GeneProduct23265 (Entrez Gene)
F-2,6-P2MetaboliteC00665 (KEGG Compound)
FASNGeneProductENSG00000169710 (Ensembl)
FBPGeneProduct2203 (Entrez Gene)
FLOT1GeneProduct10211 (Entrez Gene)
FLOT2GeneProduct2319 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
G-6-PMetaboliteC00092 (KEGG Compound)
G6PCGeneProduct2538 (Entrez Gene)
GCKGeneProduct2645 (KEGG Genes)
GLUT1GeneProduct6513 (Entrez Gene)
GLUT4GeneProduct6517 (Entrez Gene)
GRB2GeneProduct
GSGeneProduct2997 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
GlucoseMetaboliteC00031 (KEGG Compound)
GlycogenesisPathway
Glycolysis-GluconeogenesisPathwayWP534 (WikiPathways)
INSRGeneProduct3643 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
IRS4GeneProduct8471 (Entrez Gene)
Insulin Signaling Pathway Pathway
Insulin Signaling Pathway PathwayWP1982 (WikiPathways)
InsulinProteinA6XGL2 (Uniprot-TrEMBL)
LPLGeneProduct4023 (Entrez Gene)
LXRGeneProduct10062 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K10GeneProduct4294 (Entrez Gene)
MAP3K11GeneProduct4296 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K13GeneProduct9175 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K2GeneProduct10746 (Entrez Gene)
MAP3K3GeneProduct4215 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAP3K6GeneProduct9064 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP3K8GeneProduct1326 (Entrez Gene)
MAP3K9GeneProduct4293 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAP4K2GeneProduct5871 (Entrez Gene)
MAP4K3GeneProduct8491 (Entrez Gene)
MAP4K4GeneProduct9448 (Entrez Gene)
MAP4K5GeneProduct11183 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MINK1GeneProduct50488 (Entrez Gene)
Multi-drug resistancePathway
PDKGeneProduct5170 (Entrez Gene)
PEPCKGeneProduct5105 (Entrez Gene)
PI(3,4,5)P3MetaboliteC05981 (KEGG Compound) Phosphatidylinositol-3,4,5-trisphosphate(PIP3)
PI(4,5)P2MetaboliteC04637 (KEGG Compound)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PP2AGeneProduct
PPARalphaGeneProduct
PTPGeneProduct5770 (Entrez Gene) PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase
Protein synthesis and Translation RegulationPathway
RAF1GeneProduct5894 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RASGeneProduct3265 (Entrez Gene)
RHEBGeneProduct6009 (Entrez Gene)
RHOQGeneProduct23433 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KA2GeneProduct6196 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA4GeneProduct8986 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
RPS6KA6GeneProduct27330 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
RPS6KB2GeneProduct6199 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
RXRAGeneProductENSG00000186350 (Ensembl)
RaptorGeneProduct57521 (Entrez Gene)
RictorGeneProduct253260 (Entrez Gene)
SCDGeneProductENSG00000099194 (Ensembl)
SEST3GeneProduct143686 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SHC2GeneProduct25759 (Entrez Gene)
SHC3GeneProduct53358 (Entrez Gene)
SIN1GeneProduct79109 (Entrez Gene)
SLC16A2GeneProduct6567 (Entrez Gene)
SLCO1C1GeneProduct53919 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SREBP PathwayPathwayWP1982 (WikiPathways)
SREBP1a-cGeneProductENSG00000072310 (Ensembl)
SREBP2GeneProductENSG00000198911 (Ensembl)
T3Metabolite5707 (Chemspider)
T4MetaboliteHMDB0000248 (HMDB)
THRAGeneProduct7067 (Entrez Gene)
THRBGeneProduct7068 (Entrez Gene)
TSC1GeneProduct7248 (Entrez Gene)
TSC2GeneProduct7249 (Entrez Gene)
Transcription factorsPathway
Triacylglyceride SynthesisPathwayWP325 (KEGG Pathway)
X-5-PMetaboliteC00231 (KEGG Compound)
amino acidsMetaboliteCHEBI:33709 (ChEBI)
glycogenMetaboliteC00369 (KEGG Compound)
lipogenesisPathway
mTOR GeneProduct2475 (Entrez Gene)
mTORGeneProduct2475 (Entrez Gene)
mlst8GeneProduct64223 (Entrez Gene)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ArrowWP1982 (WikiPathways)
ArrowWP2882 (WikiPathways)
Arrowhsa04910 (KEGG Pathway)
Cell Growth DifferentiationArrowhsa04910 (KEGG Pathway)
DIO2mim-catalysisR03734 (KEGG Reaction)
GSTBarhsa04910 (KEGG Pathway)
GlucoseArrowhsa04911 (KEGG Pathway)
INSRArrowhsa04910 (KEGG Pathway)
PTPINSRTBarhsa04910 (KEGG Pathway)
PTPTBarhsa04910 (KEGG Pathway)
RAF1Arrowhsa04910 (KEGG Pathway)
RASArrowhsa04910 (KEGG Pathway)
RASRAF1Arrowhsa04910 (KEGG Pathway)
RHOQArrowhsa04910 (KEGG Pathway)
SLC16A2T3Arrowhsa04919 (KEGG Pathway)
SLCO1C1T4Arrowhsa04919 (KEGG Pathway)
SLCO1C1hsa04919 (KEGG Pathway)
T4T3Arrowhsa04919 (KEGG Pathway)
  • In humans 80 percent T3 is contributed via regulation from deiodinases especially DIO2.
  • The local thyroid hormone signaling is coupled with nutritional availaibility via insulin signaling.
  • Type your comment here
TBarhsa04910 (KEGG Pathway)
mim-catalysisR04545 (KEGG Reaction)
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