Angiopoietin Like Protein 8 Regulatory Pathway (Homo sapiens)

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Description

The hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated signaling events of insulin signaling in the liver.

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Ontology Terms

 

Bibliography

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  1. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed
  2. Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N; ''FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.''; Dev Cell, 2010 PubMed
  3. Tseng YH, Ke PY, Liao CJ, Wu SM, Chi HC, Tsai CY, Chen CY, Lin YH, Lin KH; ''Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism.''; Autophagy, 2014 PubMed
  4. Hay N; ''Interplay between FOXO, TOR, and Akt.''; Biochim Biophys Acta, 2011 PubMed
  5. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed
  6. Ou Z, Wada T, Gramignoli R, Li S, Strom SC, Huang M, Xie W; ''MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation.''; Mol Endocrinol, 2011 PubMed
  7. Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA; ''Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.''; PLoS One, 2016 PubMed
  8. Fu Z, Yao F, Abou-Samra AB, Zhang R; ''Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family.''; Biochem Biophys Res Commun, 2013 PubMed
  9. Yang G, Murashige DS, Humphrey SJ, James DE; ''A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.''; Cell Rep, 2015 PubMed
  10. Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL, Brown MS; ''Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase.''; Proc Natl Acad Sci U S A, 2012 PubMed
  11. Rong Guo X, Li Wang X, Chen Y, Hong Yuan Y, Mei Chen Y, Ding Y, Fang J, Jiao Bian L, Sheng Li D; ''ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3β or Akt-FoxO1 pathway in HepG2 cells.''; Exp Cell Res, 2016 PubMed
  12. Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT; ''Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.''; Science, 1997 PubMed
  13. Wang Y, Viscarra J, Kim SJ, Sul HS; ''Transcriptional regulation of hepatic lipogenesis.''; Nat Rev Mol Cell Biol, 2015 PubMed
  14. Calera MR, Vallega G, Pilch PF; ''Dynamics of protein-tyrosine phosphatases in rat adipocytes.''; J Biol Chem, 2000 PubMed
  15. Yang YM, Han CY, Kim YJ, Kim SG; ''AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability.''; World J Gastroenterol, 2010 PubMed
  16. Hashimoto K, Mori M; ''Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review].''; Endocr J, 2011 PubMed
  17. Poupeau A, Postic C; ''Cross-regulation of hepatic glucose metabolism via ChREBP and nuclear receptors.''; Biochim Biophys Acta, 2011 PubMed
  18. Taniguchi CM, Emanuelli B, Kahn CR; ''Critical nodes in signalling pathways: insights into insulin action.''; Nat Rev Mol Cell Biol, 2006 PubMed
  19. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed
  20. Yi P, Park JS, Melton DA; ''Betatrophin: a hormone that controls pancreatic β cell proliferation.''; Cell, 2013 PubMed
  21. Hashimoto K, Mori M; ''Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review].''; Endocr J, 2011 PubMed
  22. Li Y, Bolten C, Bhat BG, Woodring-Dietz J, Li S, Prayaga SK, Xia C, Lala DS; ''Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism.''; Mol Endocrinol, 2002 PubMed
  23. Tanti JF, Jager J; ''Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation.''; Curr Opin Pharmacol, 2009 PubMed
  24. Raghow R; ''Betatrophin: A liver-derived hormone for the pancreatic β-cell proliferation.''; World J Diabetes, 2013 PubMed
  25. Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R; ''Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity.''; Sci Rep, 2014 PubMed
  26. Marr MT 2nd, D'Alessio JA, Puig O, Tjian R; ''IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback.''; Genes Dev, 2007 PubMed
  27. Zhang Y, Li S, Donelan W, Xie C, Wang H, Wu Q, Purich DL, Reeves WH, Tang D, Yang LJ; ''Angiopoietin-like protein 8 (betatrophin) is a stress-response protein that down-regulates expression of adipocyte triglyceride lipase.''; Biochim Biophys Acta, 2016 PubMed
  28. Daemen S, Kutmon M, Evelo CT; ''A pathway approach to investigate the function and regulation of SREBPs.''; Genes Nutr, 2013 PubMed
  29. Chen J, Chen S, Huang P, Meng XL, Clayton S, Shen JS, Grayburn PA; ''In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats.''; Diabetologia, 2015 PubMed
  30. Ren G, Kim JY, Smas CM; ''Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism.''; Am J Physiol Endocrinol Metab, 2012 PubMed
  31. ''''; , PubMed
  32. Guo S, Dunn SL, White MF; ''The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.''; Mol Endocrinol, 2006 PubMed
  33. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed
  34. Krycer JR, Sharpe LJ, Luu W, Brown AJ; ''The Akt-SREBP nexus: cell signaling meets lipid metabolism.''; Trends Endocrinol Metab, 2010 PubMed
  35. Yellaturu CR, Deng X, Cagen LM, Wilcox HG, Mansbach CM 2nd, Siddiqi SA, Park EA, Raghow R, Elam MB; ''Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles.''; J Biol Chem, 2009 PubMed
  36. Lee J, Hong SW, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY; ''AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells.''; Mol Cell Endocrinol, 2015 PubMed
  37. Quagliarini F, Wang Y, Kozlitina J, Grishin NV, Hyde R, Boerwinkle E, Valenzuela DM, Murphy AJ, Cohen JC, Hobbs HH; ''Atypical angiopoietin-like protein that regulates ANGPTL3.''; Proc Natl Acad Sci U S A, 2012 PubMed
  38. Kenner KA, Anyanwu E, Olefsky JM, Kusari J; ''Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling.''; J Biol Chem, 1996 PubMed
  39. Vadlakonda L, Dash A, Pasupuleti M, Anil Kumar K, Reddanna P; ''The Paradox of Akt-mTOR Interactions.''; Front Oncol, 2013 PubMed
  40. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P; ''Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.''; Curr Biol, 1997 PubMed
  41. Lartey LJ, Werneck-de-Castro JP, O-Sullivan I, Unterman TG, Bianco AC; ''Coupling between Nutrient Availability and Thyroid Hormone Activation''; , 2015 PubMed
  42. Hashimoto K, Ishida E, Matsumoto S, Okada S, Yamada M, Satoh T, Monden T, Mori M; ''Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone.''; Endocrinology, 2009 PubMed
  43. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed
  44. Kwiatkowski DJ, Manning BD; ''Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.''; Hum Mol Genet, 2005 PubMed


History

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CompareRevisionActionTimeUserComment
94801view23:35, 5 October 2017AlexanderPicoConverted lines, removed nested groups and connected interactions
93137view15:19, 31 July 2017SiddiqaANGPTL8 role in CD45+ hematopoietic-derived cell proliferation
92444view06:37, 6 June 2017SiddiqaInteractions present exclusively in rat/mouse updated.
92359view08:00, 30 May 2017SusanLegend adapted
90629view14:45, 2 December 2016EgonwNo mim-conversion on gene-gene interactions.
90628view14:41, 2 December 2016EgonwRemoved type info from Entrez Gene ID.
90627view14:09, 2 December 2016EgonwUppercased c in KEGG identifier.
90610view22:11, 1 December 2016KhanspersModified description
90604view10:18, 1 December 2016Elisasolved unconnected lines
90499view14:52, 18 November 2016SusanOntology Term : 'insulin signaling pathway' added !
90498view14:51, 18 November 2016SusanModified description
90497view14:48, 18 November 2016SusanOntology Term : 'regulatory pathway' added !
90463view12:44, 17 November 2016SiddiqaModified title
90461view12:40, 17 November 2016SiddiqaAdded AUthor List
90460view11:58, 17 November 2016SiddiqaNew pathway

External references

Datanodes

View all...
NameTypeDatabase referenceComment
AMPK PathwayPathwayWP1403 (WikiPathways)
ABCG5GeneProductENSG00000138075 (Ensembl)
ABCG8GeneProductENSG00000143921 (Ensembl)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AMPKa1GeneProduct5562 (Entrez Gene)
AMPKa2GeneProduct5563 (Entrez Gene)
AMPKb1GeneProduct5564 (Entrez Gene)
AMPKb2GeneProduct5565 (Entrez Gene)
AMPKy1GeneProduct5571 (Entrez Gene)
AMPKy2GeneProduct51422 (Entrez Gene)
AMPKy3GeneProduct53632 (Entrez Gene)
ANGPTL8GeneProduct55908 (Entrez Gene)
  • synonyms: RIFL; TD26; PRO1185; PVPA599; C19orf80
  • Type your comment here
Autophagy SignalingPathway
CAP1GeneProduct10487 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CBLCGeneProduct23624 (Entrez Gene)
CD45+ hematopoietic-
  derived cell 
proliferation
PathwayWP2849 (WikiPathways)
CIP42GeneProduct9322 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CYP2B6GeneProductENSG00000197408 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
CYP7A1GeneProductENSG00000167910 (Ensembl) is not affected in human
Cell Growth DifferentiationPathwayWP2029 (WikiPathways)
ChrebpGeneProduct51085 (Entrez Gene)
DIO2GeneProduct1734 (Entrez Gene)
Drug and steroid metabolismPathway
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
Exo70GeneProduct23265 (Entrez Gene)
F-2,6-P2MetaboliteC00665 (KEGG Compound)
FASNGeneProductENSG00000169710 (Ensembl)
FBPGeneProduct2203 (Entrez Gene)
FLOT1GeneProduct10211 (Entrez Gene)
FLOT2GeneProduct2319 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
G-6-PMetaboliteC00092 (KEGG Compound)
G6PCGeneProduct2538 (Entrez Gene)
GCKGeneProduct2645 (KEGG Genes)
GLUT1GeneProduct6513 (Entrez Gene)
GLUT4GeneProduct6517 (Entrez Gene)
GRB2GeneProduct
GSGeneProduct2997 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
GlucoseMetaboliteC00031 (KEGG Compound)
GlycogenesisPathway
Glycolysis-GluconeogenesisPathwayWP534 (WikiPathways)
INSRGeneProduct3643 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
IRS4GeneProduct8471 (Entrez Gene)
Insulin Signaling Pathway Pathway
Insulin Signaling Pathway PathwayWP1982 (WikiPathways)
InsulinProteinA6XGL2 (Uniprot-TrEMBL)
LPLGeneProduct4023 (Entrez Gene)
LXRGeneProduct10062 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K10GeneProduct4294 (Entrez Gene)
MAP3K11GeneProduct4296 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K13GeneProduct9175 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K2GeneProduct10746 (Entrez Gene)
MAP3K3GeneProduct4215 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAP3K6GeneProduct9064 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP3K8GeneProduct1326 (Entrez Gene)
MAP3K9GeneProduct4293 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAP4K2GeneProduct5871 (Entrez Gene)
MAP4K3GeneProduct8491 (Entrez Gene)
MAP4K4GeneProduct9448 (Entrez Gene)
MAP4K5GeneProduct11183 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MINK1GeneProduct50488 (Entrez Gene)
Multi-drug resistancePathway
PDKGeneProduct5170 (Entrez Gene)
PEPCKGeneProduct5105 (Entrez Gene)
PI(3,4,5)P3MetaboliteC05981 (KEGG Compound) Type your comment herePhosphatidylinositol-3,4,5-trisphosphate(PIP3)
PI(4,5)P2MetaboliteC04637 (KEGG Compound)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PP2AGeneProduct
PPARalphaGeneProduct
PTPGeneProduct5770 (Entrez Gene) PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase
Protein synthesis and Translation RegulationPathway
RAF1GeneProduct5894 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RASGeneProduct3265 (Entrez Gene)
RHEBGeneProduct6009 (Entrez Gene)
RHOQGeneProduct23433 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KA2GeneProduct6196 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA4GeneProduct8986 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
RPS6KA6GeneProduct27330 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
RPS6KB2GeneProduct6199 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
RXRAGeneProductENSG00000186350 (Ensembl)
RaptorGeneProduct57521 (Entrez Gene)
RictorGeneProduct253260 (Entrez Gene)
SCDGeneProductENSG00000099194 (Ensembl)
SEST3GeneProduct143686 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SHC2GeneProduct25759 (Entrez Gene)
SHC3GeneProduct53358 (Entrez Gene)
SIN1GeneProduct79109 (Entrez Gene)
SLC16A2GeneProduct6567 (Entrez Gene)
SLCO1C1GeneProduct53919 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SREBP PathwayPathwayWP1982 (WikiPathways)
SREBP1a-cGeneProductENSG00000072310 (Ensembl)
SREBP2GeneProductENSG00000198911 (Ensembl)
T3Metabolite5707 (Chemspider)
T4MetaboliteHMDB00248 (HMDB)
THRAGeneProduct7067 (Entrez Gene)
THRBGeneProduct7068 (Entrez Gene)
TSC1GeneProduct7248 (Entrez Gene)
TSC2GeneProduct7249 (Entrez Gene)
Transcription factorsPathway
Triacylglyceride SynthesisPathwayWP325 (KEGG Pathway)
X-5-PMetaboliteC00231 (KEGG Compound)
amino acids
glycogenMetaboliteC00369 (KEGG Compound)
lipogenesisPathway
mTOR GeneProduct2475 (Entrez Gene)
mTORGeneProduct2475 (Entrez Gene)
mlst8GeneProduct64223 (Entrez Gene)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ArrowWP1982 (WikiPathways)
ArrowWP2882 (WikiPathways)
Arrowhsa04910 (KEGG Pathway)
Cell Growth DifferentiationArrowhsa04910 (KEGG Pathway)
DIO2mim-catalysisR03734 (KEGG Reaction)
GSTBarhsa04910 (KEGG Pathway)
GlucoseArrowhsa04911 (KEGG Pathway)
INSRArrowhsa04910 (KEGG Pathway)
PTPINSRTBarhsa04910 (KEGG Pathway)
PTPTBarhsa04910 (KEGG Pathway)
RAF1Arrowhsa04910 (KEGG Pathway)
RASArrowhsa04910 (KEGG Pathway)
RASRAF1Arrowhsa04910 (KEGG Pathway)
RHOQArrowhsa04910 (KEGG Pathway)
SLC16A2T3Arrowhsa04919 (KEGG Pathway)
SLCO1C1T4Arrowhsa04919 (KEGG Pathway)
SLCO1C1hsa04919 (KEGG Pathway)
T4T3Arrowhsa04919 (KEGG Pathway)
  • In humans 80 percent T3 is contributed via regulation from deiodinases especially DIO2.
  • The local thyroid hormone signaling is coupled with nutritional availaibility via insulin signaling.
  • Type your comment here
TBarhsa04910 (KEGG Pathway)
mim-catalysisR04545 (KEGG Reaction)
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