Lipid Droplet Metabolism (Rattus norvegicus)

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1Lipid Droplet Structural ProteinsFatty AcidsActivationAup1Acyl-CoAFitm2Bscl2Acsl1Plin2DAGFatty AcidsCholesterolAcsl3Acsl4PhosphatidicAcidGlycerolPnpla2TriglyceridesCholesterol EstersDgat1Dgat2Soat1Soat2LipaLipaLysoPhosphatidicAcidGlycerol-3-PDHA-PGkGpat2Agpat3Agpat1Agpat4Agpat2Agpat5Lpin1Lpin2Lpin3Gpd1Gpd2


Lipid droplets are cytosolic organelles present in nearly all cell types. Initially they were considered only as inert lipid-storage sites, but now they are recognized to be involved in other functions and even associated with liver and kidney disease. Still, the mechanisms for lipid accumulation into the lipid droplet are not totally understood. Even though the lipid and protein composition of the lipid droplets is highly dynamic, triglycerides and cholesterol esters are the main components of them. This pathway features the basic enzymatic steps necessary to esterify glycerol and cholesterol.

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Ontology Terms



  1. Pol A, Gross SP, Parton RG; ''Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites.''; J Cell Biol, 2014 PubMed


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90646view18:54, 4 December 2016AlexanderPicoUpdated catalysis reactions
90414view08:16, 12 November 2016EgonwAdded ChEBI identifiers for a few compound classes.
90413view08:10, 12 November 2016EgonwIdentifiers are case sensitive.
90315view21:46, 3 November 2016AgustinGV
90307view19:58, 3 November 2016AgustinGVFix IDs
90303view18:15, 3 November 2016AgustinGVOntology Term : 'lipid metabolic pathway' added !
90302view18:14, 3 November 2016AgustinGVOntology Term : 'lipid metabolism disorder' added !
90301view18:14, 3 November 2016AgustinGVOntology Term : 'neutral lipid storage disease' added !
90300view18:12, 3 November 2016AgustinGV
90299view18:09, 3 November 2016AgustinGVModified description
90298view17:54, 3 November 2016AgustinGV
90297view17:52, 3 November 2016AgustinGV
90296view17:44, 3 November 2016AgustinGVNew pathway

External references


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NameTypeDatabase referenceComment
Acsl1GeneProduct25288 (Entrez Gene)
Acsl3GeneProduct114024 (Entrez Gene)
Acsl4GeneProduct113976 (Entrez Gene)
Acyl-CoAMetaboliteCHEBI:58342 (ChEBI)
Agpat1GeneProduct406165 (Entrez Gene)
Agpat2GeneProduct311821 (Entrez Gene)
Agpat3GeneProduct294324 (Entrez Gene)
Agpat4GeneProduct170919 (Entrez Gene)
Agpat5GeneProduct306582 (Entrez Gene)
Aup1GeneProduct680423 (Entrez Gene)
Bscl2GeneProduct361722 (Entrez Gene)
Cholesterol EstersMetaboliteCHEBI:17002 (ChEBI)
CholesterolMetaboliteHMDB00067 (HMDB)
DHA-PMetaboliteHMDB01473 (HMDB)
Dgat1GeneProduct84497 (Entrez Gene)
Dgat2GeneProduct252900 (Entrez Gene)
Fatty AcidsMetaboliteCHEBI:35366 (ChEBI)
Fitm2GeneProduct311617 (Entrez Gene)
GkGeneProduct79223 (Entrez Gene)
Glycerol-3-PMetaboliteHMDB00126 (HMDB)
GlycerolMetaboliteHMDB00131 (HMDB)
Gpat2GeneProduct296130 (Entrez Gene)
Gpd1GeneProduct60666 (Entrez Gene)
Gpd2GeneProduct25062 (Entrez Gene)
LipaGeneProduct25055 (Entrez Gene)
Lpin1GeneProduct313977 (Entrez Gene)
Lpin2GeneProduct316737 (Entrez Gene)
Lpin3GeneProduct362261 (Entrez Gene)
LysoPhosphatidic AcidMetabolite
Phosphatidic AcidMetaboliteCHEBI:16337 (ChEBI)
Plin2GeneProduct298199 (Entrez Gene)
Pnpla2GeneProduct361676 (Entrez Gene)
Soat1GeneProduct81782 (Entrez Gene)
Soat2GeneProduct266770 (Entrez Gene)
TriglyceridesMetaboliteCHEBI:17855 (ChEBI)

Annotated Interactions

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