Dengue-2 Interactions with Blood Clotting Cascade (Homo sapiens)

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1Extrinsic PathwayFactor XIaFactor XIIaFactor XIIIaFibrin PolymerFactor VIIaEnvFactor IXaPlasminIntrinsic PathwayTissue Injury+ Fibrin Split ProductsFibrin MonomerEnv/PrM+ThrombolysisFactor VIIIaTissue Factor 2FGGProthrombinase ComplexZincFactor XIIPLATKLKB1FibrinSERPINB2VWFFactor IIKLK1Factor XSERPINF2Factor VIIFactor XFactor XIIIbPLAUSERPINE1Factor VIII A1FGAFactor XIFactor XaPLGFactor VIIIFactor VFactor IXFGBThrombin (II)Factor Va


Dengue virus infection can give rise to hemorrhagic shock. Highlighted in red are Dengue-2 structural protein interactions with human proteins involved in coagulation, building upon the canonical Blood Clotting Cascade described in by the following text:

Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis).

Source: Wikipedia

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Ontology Terms



  1. Luchtman-Jones L, Broze GJ Jr; ''The current status of coagulation.''; Ann Med, 1995 PubMed Europe PMC
  2. Folly BB, Weffort-Santos AM, Fathman CG, Soares LR; ''Dengue-2 structural proteins associate with human proteins to produce a coagulation and innate immune response biased interactome.''; BMC Infect Dis., 2011 PubMed Europe PMC


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106150view12:04, 16 August 2019MaintBotHMDB identifier normalization
90039view21:51, 8 October 2016MaintBotOntology Term : 'coagulation cascade pathway' added !
90038view21:51, 8 October 2016MaintBotOntology Term : 'dengue disease' added !
90037view21:50, 8 October 2016MaintBotAdded reference for dengue-2 interactions in red
90036view21:48, 8 October 2016MaintBotModified description
90035view21:46, 8 October 2016MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
FGAGeneProductENSG00000171560 (Ensembl)
FGBGeneProductENSG00000171564 (Ensembl)
FGGGeneProductENSG00000171557 (Ensembl)
Factor IIGeneProductENSG00000180210 (Ensembl)
Factor IXGeneProductENSG00000101981 (Ensembl)
Factor IXaGeneProductENSG00000101981 (Ensembl)
Factor VGeneProductENSG00000198734 (Ensembl)
Factor VIIGeneProductENSG00000057593 (Ensembl)
Factor VIII A1GeneProductENSG00000277203 (Ensembl)
Factor VIIIGeneProductENSG00000185010 (Ensembl)
Factor VIIIaGeneProductENSG00000185010 (Ensembl)
Factor VIIaGeneProductENSG00000057593 (Ensembl)
Factor VaGeneProductENSG00000198734 (Ensembl)
Factor XGeneProductENSG00000126218 (Ensembl)
Factor XIGeneProductENSG00000088926 (Ensembl)
Factor XIIGeneProductENSG00000131187 (Ensembl)
Factor XIIIaGeneProductENSG00000143278 (Ensembl)
Factor XIIIbGeneProductENSG00000143278 (Ensembl)
Factor XIIaGeneProductENSG00000131187 (Ensembl)
Factor XIaGeneProductENSG00000088926 (Ensembl)
Factor XaGeneProductENSG00000126218 (Ensembl)
FibrinMetabolite9001-31-4 (CAS)
KLK1GeneProductENSG00000167748 (Ensembl)
KLKB1GeneProductENSG00000164344 (Ensembl)
PLATGeneProductENSG00000104368 (Ensembl)
PLAUGeneProductENSG00000122861 (Ensembl)
PLGGeneProductENSG00000122194 (Ensembl)
Prothrombinase ComplexGeneProduct
SERPINB2GeneProductENSG00000197632 (Ensembl)
SERPINE1GeneProductENSG00000106366 (Ensembl)
SERPINF2GeneProductENSG00000167711 (Ensembl)
Thrombin (II)GeneProductENSG00000180210 (Ensembl)
VWFGeneProductENSG00000110799 (Ensembl)
ZincMetaboliteHMDB0001303 (HMDB)

Annotated Interactions

No annotated interactions

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