Dengue-2 Interactions with Complement and Coagulation Cascades (Homo sapiens)

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Cell adhesion,migration,proliferation, etcC3b/BbCross-linkedfibrin polymerLectin PathwayPlatelet, monocyte,lymphocyte,endothelial cells,smooth muscle cellsactivation, etcAntibody/antigencomplexC4b/2aFibrinolytic systemCell lysisExtrinsic pathwayDegradationC4aAlternative PathwayCell adhesion,migration,proliferation, etcZymosan,insulin, etc.Collagen,basement membrane,activated platelets, etc.C3aComplement Cascadefibrin degradationproductsMuscle contraction,Chemotaxis,Phagocyte recruitmentInflammation, etc.Vascular injuryClotCoagulation CascadeC3ConvertaseC5aC3b/4b, C3b, C3dKinin kallikrein systemC3bmembrane attack complexClassical PathwayMediatorsThrombinCR1PLGC3AR1Fibrin monomerPrM/CapMASP1CFHF5A2MKLKB1C3C6C5R1SERPIND1109821F12F13BDaf2C1SDaf1APOA2SERPINF2SERPINA1THBDPLAUCRRYSERPINE1CR2MBL1MASP2SERPINA5CPB2PrM/CapSERPING1F3H2-BFC1RCLUC1QGADNPROCC9BradykininC2PROS1C1QAPLATHcF7VWFTFPICFIC4F8CD59APLAURKNG1SERPINC1FGBBDKRB1C8GF2RF9F10F2C1QBMCPC71


Dengue virus infection can give rise to hemorrhagic shock. Highlighted in red are Dengue-2 structural protein interactions with human proteins involved in coagulation, building upon the canonical Complement and Coagulation Cascades described in by the following text:

Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens.

Source: KEGG (

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Ontology Terms



  1. Folly BB, Weffort-Santos AM, Fathman CG, Soares LR; ''Dengue-2 structural proteins associate with human proteins to produce a coagulation and innate immune response biased interactome.''; BMC Infect Dis., 2011 PubMed Europe PMC Scholia


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94779view21:54, 5 October 2017AlexanderPicoRemoved nested groups and checked connected lines
90040view21:51, 8 October 2016MaintBotOntology Term : 'coagulation cascade pathway' added !
90008view23:18, 7 October 2016MaintBotOntology Term : 'dengue disease' added !
90007view23:17, 7 October 2016MaintBotAdded Dengue reference and updated red paths
90006view23:05, 7 October 2016MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
109821GeneProduct109821 (Entrez Gene)
A2MGeneProduct2 (Entrez Gene)
ADNGeneProduct1675 (Entrez Gene)
APOA2GeneProductENSG00000158874 (Ensembl)
BDKRB1GeneProduct623 (Entrez Gene)
BradykininMetabolite58-82-2 (CAS)
C1QAGeneProduct712 (Entrez Gene)
C1QBGeneProduct713 (Entrez Gene)
C1QGGeneProduct714 (Entrez Gene)
C1RGeneProduct715 (Entrez Gene)
C1SGeneProduct716 (Entrez Gene)
C2GeneProduct717 (Entrez Gene)
C3GeneProduct718 (Entrez Gene)
C3AR1GeneProduct719 (Entrez Gene)
C4GeneProduct721 (Entrez Gene)
C5R1GeneProduct728 (Entrez Gene)
C6GeneProduct729 (Entrez Gene)
C7GeneProduct730 (Entrez Gene) MGI:88235 LL:109828
C8GGeneProduct733 (Entrez Gene)
C9GeneProduct735 (Entrez Gene)
CFHGeneProduct3075 (Entrez Gene)
CFIGeneProduct3426 (Entrez Gene)
CLUGeneProduct1191 (Entrez Gene)
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CPB2GeneProduct1361 (Entrez Gene)
CR1GeneProduct1378 (Entrez Gene)
CR2GeneProduct1380 (Entrez Gene)
Daf1GeneProduct1604 (Entrez Gene)
F10GeneProduct2159 (Entrez Gene)
F12GeneProduct2161 (Entrez Gene)
F13BGeneProduct2165 (Entrez Gene)
F2GeneProduct2147 (Entrez Gene)
F2RGeneProduct2149 (Entrez Gene)
F3GeneProduct2152 (Entrez Gene)
F5GeneProduct2153 (Entrez Gene)
F7GeneProduct2155 (Entrez Gene)
F8GeneProduct2157 (Entrez Gene)
F9GeneProduct2158 (Entrez Gene)
FGBGeneProduct2244 (Entrez Gene)
Fibrin monomerMetabolite9001-31-4 (CAS)
H2-BFGeneProduct629 (Entrez Gene)
HcGeneProduct1213 (Entrez Gene)
KLKB1GeneProduct3818 (Entrez Gene)
KNG1GeneProduct3827 (Entrez Gene)
MASP1GeneProduct5648 (Entrez Gene)
MASP2GeneProduct10747 (Entrez Gene)
MBL1GeneProduct3998 (Entrez Gene)
MCPGeneProduct4179 (Entrez Gene)
PLATGeneProduct5327 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PLAURGeneProduct5329 (Entrez Gene)
PLGGeneProduct5340 (Entrez Gene)
PROCGeneProduct5624 (Entrez Gene)
PROS1GeneProduct5627 (Entrez Gene)
SERPINA1GeneProduct5265 (Entrez Gene)
SERPINA5GeneProduct5104 (Entrez Gene)
SERPINC1GeneProduct462 (Entrez Gene)
SERPIND1GeneProduct3053 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SERPINF2GeneProduct5345 (Entrez Gene)
SERPING1GeneProduct710 (Entrez Gene)
TFPIGeneProduct7035 (Entrez Gene)
THBDGeneProduct7056 (Entrez Gene)
VWFGeneProduct7450 (Entrez Gene)

Annotated Interactions

No annotated interactions

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