Benzene metabolism (Homo sapiens)

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1NonenzymaticrearrangementMicrosomal Epoxide Hydrolasep-benzoquinonePhenolCYP2E1OxepineS-Phenylmercapturic acidCYP2E11,2-BenzoquinoneMPOCatecholBenzene dihydrodiolNQO1Glutathione S-transferaseNQO1Benzene diol epoxideDihydrodioldehydrogenaseBenzene oxideHydroquinoneBenzeneMPO


This pathway describes the metabolism of benzene. It is metabolised in the liver and forms several metabolites that can be toxic to the human body. Some of the metabolites are very volatile and can be found in blood and exhaled breath.

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Ontology Terms



  1. Rappaport SM, Kim S, Lan Q, Vermeulen R, Waidyanatha S, Zhang L, Li G, Yin S, Hayes RB, Rothman N, Smith MT; ''Evidence that humans metabolize benzene via two pathways.''; Environ Health Perspect, 2009 PubMed


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94538view07:01, 21 September 2017EgonwRemoved a redundant newline.
89359view13:30, 7 September 2016Riannefijtenadded identifier vor microsomal epoxide hydrolase
89346view09:52, 6 September 2016RiannefijtenModified description
89345view09:52, 6 September 2016RiannefijtenModified description
89344view04:35, 6 September 2016EgonwUsed mim-conversion and annotated the catalysis with a mim approach too.
89339view03:16, 5 September 2016EgonwOntology Term : 'classic metabolic pathway' added !
89338view03:16, 5 September 2016EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
89313view13:15, 1 September 2016RiannefijtenNew pathway

External references


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NameTypeDatabase referenceComment
1,2-BenzoquinoneMetaboliteHMDB12133 (HMDB)
Benzene dihydrodiolMetabolite418 (PubChem-compound)
Benzene diol epoxideMetabolite
Benzene oxideMetabolite104944 (PubChem-compound)
BenzeneMetaboliteHMDB01505 (HMDB)
CYP2E1GeneProductENSG00000130649 (Ensembl)
CatecholMetabolite289 (PubChem-compound)
Dihydrodiol dehydrogenaseProtein27294 (Entrez Gene)
Glutathione S-transferaseGeneProduct2944 (Entrez Gene)
HydroquinoneMetaboliteHMDB02434 (HMDB)
MPOGeneProduct4353 (Entrez Gene)
Microsomal Epoxide HydrolaseGeneProduct2052 (Entrez Gene)
NQO1GeneProductENSG00000181019 (Ensembl)
OxepineMetabolite6451477 (PubChem-compound)
PhenolMetaboliteHMDB00228 (HMDB)
S-Phenylmercapturic acidMetaboliteHMDB42011 (HMDB)
p-benzoquinoneMetabolite4650 (PubChem-compound)

Annotated Interactions

No annotated interactions

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