VEGFA-VEGFR2 Signaling Pathway (Homo sapiens)
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27
STAT3
P
ROCK2
PRKD2
53
53
27, 102
MAPK3
T202
Y204
MAPK1
T185
Y187
58
126, 129
MAPK1
Y187
T185
155
214, 271
230
123
6, 22, 245
254
47
58, 234
MAP2K3
MAP2K6
P
249
39
MAPK9
MAPK8
Y185
T183
STAT3
P
MAPK3
T183
228
MAPK3
T202
Y204
186
45, 123, 146, 173
MAPK1
Y185
127
PRKCZ
128, 238
PIK3R2
ACACB
NCF2
MAPK12
RAP1B
33
VEGFR2
Y996
Y1214
MeK1041
Y1175
Y1059
Y1054
Y951
89
201
188, 214
149
AP1
complex
Soluble and
cleaved FLT1
may sequester
VEGFA from
VEGFR2
PKC delta/
Zeta
dependent
Epoxyeicosatrienoic
acid regioisomers
EC proliferation,
migration,
tube formation
and angiogenesis
CY
Cell motility
and tube
formation
EC Migration and
Tube Formation
ABCF2
33, 114
18
FADD
TCEB3
FAF1
FAS
BIN1
BMX
HDAC1
TNFRSF10C
HSPA1A
SMARCA2
57
DOK1
P
GAB1
P
Receptor
PROTEIN
Ligand
Protein translocation
LEGEND
Multiple colored edges are introduced to distinguish the connecting nodes
Phosphorylated form with/without site & residue
Endosome
Nucleus
Mitochondrion
Cytoplasm
Plasma membrane
MT
Endoplasmic reticulum
CY
PM
NU
ER
EN
VEGFR2
Y1175
Y1214
Y1059
Y1054
Y951
Y801
30
VEGFA
259
MAPK14
P
117, 190
117
F-actin
reorganization
117, 162
117
Stress fibre
formation
Focal adhesion
assembly and
cell migration
117
NCK1
P
FYN
P
PAK2
P
33
STAT1
P
STAT6
P
105, 137
STAT1
P
STAT6
P
137
NU
FRS2
P
CRK
P
PRKCI
15
15
15
15
33
SRC
Y419
Y530
20
87
RAPGEF1
186
186
RAP1A
GTP
186
ITGAV
ITGB3
Y773
186
BCAR1
P
176
30, 187
PLCG1
Ub
Y783
16
SHC1
187, 213
SHC2
187
33, 127
PTK2
Y861
Y576
Y397
Y407
S732
168
IQGAP1
P
RAC1
133, 207
GTP
149
149
Directed
Cell migration
135, 149, 215
ITGB5
ITGB1
ITGAV
17
17, 81
17
17
222
SH2D2A
175
175
223
Vascular
permeability
NAADP
65
TPCN2
Ca2+
Ca2+
Ca2+
Ca2+
Ca2+
Ca2+
65
65
H+
H+
H+
ATP
ADP
65
65
65
Endolysosomal
calcium store
MAPKAPK2
T334
69, 190
190
190
190
PLAU
PIP2
IP3
DAG
274
274
274
CAPN2
138
Ca2+
Ca2+
Ca2+
166
MYL2
S20
T19
168
Endothelial cell
contraction at
high VEGFA levels
168
51
ROCK1
P
51, 75
RHOA
GTP
35, 50, 51, 75, 119...
207
RHOC
GTP
3, 228
Endothelial cell
Proliferation
and migration
228
228
MAP2K1
S222
S218
188, 228
228
20, 163
CBL
163
163
163
ITPR1
274
228
PRKCB
PRKCA
S657
90
RAF1
P
6, 90, 254
SPHK1
P
HRAS
19
GTP
274
10
PRKD1
S742
S910
S738
155
10
18, 155
HDAC5
S498
S259
155
HDAC5
S498
S259
PRKCD
PRKCE
PLA2G4A
P
6
6, 22
PGI2
HSPB1
92
S78
S15
S82
150
NRP1
130, 201
CAV1
Y14
87
87
87
CDH5
106
PTPN11
106
CSK
106
106
106
74
PTK2B
Y402
132
128, 185
HSP90AA1
46
46
46, 185
267
MLLT4
210
210
FHL2
140
140
38
PLCB3
S1105
S537
26
26
CDC42
GTP
26
WASF1
NCF1
P
PAK1
P
140
152
152
PTPN9
88
PTPRZ1
60
60
60
60
NCL
MYH9
NCL
122
122
122
122
109
AKT1
S473
T308
109
FOXO1
S256
AKT1
T308
S473
23, 109, 202
109
FOXO1
S256
109, 249
109
106, 109, 250
RELA
NFKBIA
268
P
91
91
63, 91, 165, 261
91
PLA2G5
RPS6KA5
P
76
76
76
136, 154
PIK3R1
P
73
154, 202
NOS3
S114
S1179
16
92, 138, 154
NO
154
LIMK1
S323
CFL1
S3
92
162
162
150, 162
VAV2
Y172
50
50, 100
FLNB
98
98, 204
98
PFN1
Y129
4
4
G-actin binding
and actin
polymerization
4
At cell
leading
edge
11
42, 234
ATF2
T71
T69
Promotes endothelial-
leukocyte interactions
234
234
58
Endothelial
cell survival
58, 134
GRB2
P
20
20, 100
46, 238
PXN
pY
9, 128, 203
36
GJA1
S282
S368
S255
S279
S262
184
Clathrin
mediated
Gap junction
internalization
123
GJA1
S279
S255
S368
S262
S282
Stress fibre
formation
11
PTPRJ
250, 251
250, 251
250
SHB
P
129
129
129
129
114, 235
114, 235
114
185
185
ROCK1
P
185
RPS6KB1
T412
56
TXNIP
ACP1
S-glutathionylation
56, 131
TXN
56
56, 131
ONOO-
56
56
109, 273
Cysteine
oxidation
of VEGFR2
and SRC
PTPN6
216
216
GRB10
P
55
31, 152
PRKAA1
T183
ROS
Mitochondrial
215
31
Cytosolic
ROS
79
Angiogenesis
79
79, 85
49, 121, 246
cGMP
121, 164
Angiogenesis
49, 121, 246
CREB1
P
68
CAMKK2
85, 217
ACACA
P
85, 200
85, 217
PRKAA2
215
ARHGEF15
64
64
RHOJ
257
GTP
64
64
126
SHC1
S36
126, 213
PDPK1
S241
214
PIP2
PIP3
R1CTOR
MLST8
MAPKAP1
MTOR
S2448
S2481
199
199
MTOR
RAPTOR
MLST8
214
214
214
NRDG1
T345
mTORC2
mTORC1
142