Angiotensin II signaling (acute) in thick ascending limbs (Rattus norvegicus)

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The thick ascending limb of the loop pf Henle reabsorbs 25 to 30 % of the NaCl filtered through the glomerulus. Abnormally elevated Na reabsorption by this segment is link to salt-sensitive hypertension. Ang II is an important regulator of transport in the thick ascending limb, in part due to its modulatory effects on the balance between nitric oxide and superoxide. This pathway features the acute effects of Ang II in NO and O2- production in thick ascending limb. The information presented here is based on both genomic and physiological data.

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History

View all...
CompareRevisionActionTimeUserComment
95169view20:11, 20 November 2017SusanAnnotated protein
95162view17:55, 17 November 2017AgustinGVModified title
95161view17:53, 17 November 2017AgustinGVAdding 20-HETE pw
94514view19:11, 16 September 2017AlexanderPicoRemoved "undefined" xref values
94478view18:45, 12 September 2017AgustinGV
94477view18:43, 12 September 2017AgustinGV
94476view18:35, 12 September 2017AgustinGVQuick edit to datanode annotation or property
92339view12:32, 25 May 2017AgustinGV
92338view12:30, 25 May 2017AgustinGVcorrect alignment
91518view20:55, 8 March 2017Khanspersadded ids for some metabolites
91331view18:19, 2 February 2017Khanspersconnected interactions
90426view19:54, 15 November 2016AgustinGV
89600view16:04, 19 September 2016AgustinGV
89588view15:45, 19 September 2016AgustinGVOntology Term : 'kidney loop of henle thick ascending limb epithelial cell' added !
89587view15:45, 19 September 2016AgustinGVOntology Term : 'renal hypertension' added !
89576view15:31, 19 September 2016AgustinGVModified description
89568view07:52, 17 September 2016EgonwReplaced an secondary HMDB id with the main ID.
89402view19:49, 10 September 2016AlexanderPicoOntology Term : 'signaling pathway' added !
89401view19:49, 10 September 2016AlexanderPicoOntology Term : 'angiotensin signaling pathway' added !
89248view17:49, 25 August 2016AgustinGVSpecify description
89239view21:35, 24 August 2016AgustinGVModified description
89214view14:05, 23 August 2016AgustinGVSpecify description
89213view14:03, 23 August 2016AgustinGVNew pathway

External references

Datanodes

View all...
NameTypeDatabase referenceComment
20-HETEMetaboliteHMDB0005998 (HMDB)
AAMetaboliteCHEBI:01043 (ChEBI)
AMPMetaboliteHMDB03540 (HMDB)
AT1R APGeneProduct298646 (Entrez Gene)
AT1aGeneProduct24180 (Entrez Gene)
AT1bGeneProduct81638 (Entrez Gene)
AT2RGeneProduct24182 (Entrez Gene)
Akt1 / PKBProtein24185 (Entrez Gene)
Akt2 / PKBProtein25233 (Entrez Gene)
Akt3 / PKBProtein29414 (Entrez Gene)
B-Arrestin 2GeneProduct25388 (Entrez Gene)
Ca2+MetaboliteHMDB00464 (HMDB)
Calmodulin 1GeneProduct24242 (Entrez Gene)
Calmodulin 2GeneProduct50663 (Entrez Gene)
Calmodulin 3GeneProduct24244 (Entrez Gene)
DAGMetaboliteCHEBI:4481 (ChEBI)
Dynamin 1 GeneProduct140694 (Entrez Gene)
Dynamin 2GeneProduct25751 (Entrez Gene)
G alfa-11GeneProduct81662 (Entrez Gene)
G alfa-QGeneProduct81666 (Entrez Gene)
IP3MetaboliteHMDB01498 (HMDB)
Itpr1GeneProduct25262 (Entrez Gene)
Itpr2GeneProduct81678 (Entrez Gene)
Itpr3GeneProduct25679 (Entrez Gene)
Mas1Protein25153 (Entrez Gene)
NOMetaboliteHMDB03378 (HMDB)
NOS3GeneProduct24600 (Entrez Gene)
NOX4GeneProduct85431 (Entrez Gene)
PDE 2aGeneProduct81743 (Entrez Gene)
PDPK1GeneProduct81745 (Entrez Gene)
PI3KProtein
PIP2Metabolite21169207 (Chemspider)
PIP3MetaboliteQ3078767 (Wikidata)
PKAProtein3389 (RGD)
PKCaGeneProduct24680 (Entrez Gene)
PKCgGeneProduct24681 (Entrez Gene)
PLA2GeneProduct
PLC g1GeneProduct25738 (Entrez Gene)
PLC g2GeneProduct29337 (Entrez Gene)
PTENProtein50557 (Entrez Gene)
Rac1GeneProduct85431 (Entrez Gene)
SuperoxideMetaboliteHMDB02168 (HMDB)
Uncoupled NOSsGeneProduct24600 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)
cit-P450GeneProduct

Annotated Interactions

No annotated interactions

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