4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression (Homo sapiens)

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1AMP/ATP RatioPI3KHypomethylation of 5' mRNA capPrevention of CancerAAICA Riboside Compound CRetinoic Acids?SB2021904-HydroxytamoxifenERK2AMPKMTOR Protein Kinase Signaling PathwayRafp38MAPKmTOReIF4ETSCERK Inhibitor IMKK3Mlk3AKTMNK1MKK6NSC119889RotenoneCap-Independent Translation Initiation of p27 mRNA Through its 5'UTRMNK2PD98059DexamethasoneERK1MEK1PBKEIF4EBP1LY 294, 002MEK2Triciribine4-HydroxytamoxifenPPPDexamethasoneEIF4EBP1PCap-Independent Translation Initiation of p27 mRNA Through its 5'UTRPrevention of CancerBReceptor Tyrosine Kinases


This pathway is modeled after Figure 7 in the article Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids (See Bibliography). Several anticancer agents up-regulate expression of p27, a cyclin-dpendent kinase inhibitor that blocks the transition from G1 to S phase. The pathways used by the anticancer agents (retinoic acids, 4-hydroxytamoxifen, dexamethasone) are shown above from human breast cancer cells.

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  1. Eto I; ''Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.''; Cancer Cell Int, 2010 PubMed Europe PMC Scholia


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123400view06:27, 23 July 2022EgonwMade a pathway clickable
120671view01:25, 23 December 2021EweitzModified title
108131view10:29, 29 November 2019FehrhartOntology Term : 'cancer' added !
108130view10:29, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
105282view17:15, 26 July 2019AriuttaHMDB01852 -> HMDB0001852
97670view08:33, 1 June 2018AMTanOntology Term : 'breast cancer' added !
94799view23:22, 5 October 2017AlexanderPicoConnected interactions
94710view05:04, 5 October 2017EgonwRemoved redundant newlines.
94709view05:04, 5 October 2017EgonwReplaced the PubChem CID from the salt with that of the parent compound.
90124view04:52, 14 October 2016Khanspersswitched the two panels
90123view04:49, 14 October 2016Khansperssimplified
88971view22:40, 17 August 2016AAR&CoModified title
88970view22:40, 17 August 2016AAR&CoOntology Term : 'breast cancer pathway' added !
88969view22:39, 17 August 2016AAR&CoModified description
88968view22:35, 17 August 2016AAR&CoAdded labels
88967view22:33, 17 August 2016AAR&CoAdded additional related pathway
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88857view16:01, 16 August 2016AAR&CoModified description
88855view15:54, 16 August 2016AAR&CoAdded Literature Reference
88852view15:51, 16 August 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
4-HydroxytamoxifenMetabolite449459 (PubChem-compound)
AICA Riboside Compound CMetabolite17513 (PubChem-compound)
AKTGeneProductENSG00000142208 (Ensembl)
AMPKGeneProductQ13131 (Uniprot-TrEMBL)
Cap-Independent Translation Initiation of p27 mRNA Through its 5'UTRPathwayIdentifier not found
DexamethasoneMetabolite5743 (PubChem-compound)
EIF4EBP1GeneProductENSG00000187840 (Ensembl)
ERK Inhibitor IMetabolite3377241 (PubChem-compound)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
LY 294, 002Metabolite3973 (PubChem-compound)
MEK1GeneProductENSG00000169032 (Ensembl)
MEK2GeneProductENSG00000126934 (Ensembl)
MKK3GeneProductENSG00000034152 (Ensembl)
MKK6GeneProductENSG00000108984 (Ensembl)
MNK1GeneProductENSG00000079277 (Ensembl)
MNK2GeneProductENSG00000099875 (Ensembl)
MTOR Protein Kinase Signaling PathwayPathwayWP3318 (WikiPathways)
Mlk3GeneProductENSG00000173327 (Ensembl)
NSC119889Metabolite274104 (PubChem-compound)
PBKGeneProductENSG00000168078 (Ensembl)
PD98059Metabolite4713 (PubChem-compound)
RafGeneProductENSG00000132155 (Ensembl)
Retinoic Acids?MetaboliteHMDB0001852 (HMDB)
RotenoneMetabolite6758 (PubChem-compound)
SB202190Metabolite5353940 (PubChem-compound)
TSCGeneProductENSG00000165699 (Ensembl)
TriciribineMetabolite65399 (PubChem-compound)
eIF4EGeneProductENSG00000151247 (Ensembl)
mTORGeneProductENSG00000198793 (Ensembl)
p38MAPKGeneProductENSG00000197442 (Ensembl)

Annotated Interactions

No annotated interactions

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