BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation (Homo sapiens)

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1FOXO1 TargetsSMAD-mediated signalingDKKsSMAD1SMAD5FOXO1WNT4BMP2SMAD8Differentiation of Human Endometrial Stromal CellsB-CateninDCNSSTcAMPSFRPsBCL2L11LEFTY2


This pathway is based on figure 6 from Li et al. BMP2 is activated by cAMP which promotes WNT4 expression in Human Primary Endometrial Stromal Cells (HPESCs) through SMAD1/5/8. WNT4 then induces FOXO1 function through B-Catenin which indirectly stimulates HPESC differentiation. DKKs and SFRPs are activated by BMP2 inhibit WNT4 and stop downstream signaling. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Li Q, Kannan A, Das A, Demayo FJ, Hornsby PJ, Young SL, Taylor RN, Bagchi MK, Bagchi IC; ''WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal celldifferentiation.''; Endocrinology, 2013 PubMed Europe PMC Scholia


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106755view13:23, 17 September 2019MaintBotHMDB identifier normalization
106308view17:46, 20 August 2019KhanspersModified description
105539view06:06, 9 August 2019KhanspersModified description
94744view15:12, 5 October 2017Mkutmonfix unconnected line
90122view04:37, 14 October 2016Khanspersfixed unconnected
89273view05:11, 29 August 2016Khanspersupdated layout, added nodes
89060view06:40, 19 August 2016Fehrhartconnected line
88814view22:41, 14 August 2016AAR&CoOntology Term : 'Wnt signaling pathway' added !
88813view22:41, 14 August 2016AAR&CoOntology Term : 'stromal cell' added !
88812view22:39, 14 August 2016AAR&CoModified description
88811view22:31, 14 August 2016AAR&CoModified title
88810view22:31, 14 August 2016AAR&CoModified description
88809view22:30, 14 August 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
B-CateninProteinB4DGU4 (Uniprot-TrEMBL)
BCL2L11GeneProductENSG00000153094 (Ensembl)
BMP2GeneProductENSG00000125845 (Ensembl)
DCNGeneProductENSG00000011465 (Ensembl)
DKKsGeneProductO94907 (Uniprot-TrEMBL) Protein Family
Differentiation of Human Endometrial Stromal CellsPathwayWP2848 (WikiPathways)
FOXO1GeneProductENSG00000150907 (Ensembl)
LEFTY2GeneProductENSG00000143768 (Ensembl)
SFRPsGeneProductENSG00000104332 (Ensembl) Protein Family
SMAD1GeneProductENSG00000170365 (Ensembl)
SMAD5GeneProductENSG00000113658 (Ensembl)
SMAD8GeneProductENSG00000120693 (Ensembl)
SSTGeneProductENSG00000157005 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions

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