ATR Signaling (Homo sapiens)

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19-1-1 ComplexCell Arrest CycleOrigin FiringReplisome Stability1. ATR+ATRIP Recruitment3. Substrate Phosphorylation2. 9-1-1 & TOPBP1 Recruitment and ATR ActivationDNARAD9ARAD9BHUS1RAD1CHK1PPPRPAATRATRIPRPARPARPARPADNARPARPARPARPARPAATRATRIPDNARPARPARPARPARPAATRATRIPPTOPBP19-1-1 ComplexHUS1RAD9BRAD9ARAD1


This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Nam EA, Cortez D; ''ATR signalling: more than meeting at the fork.''; Biochem J, 2011 PubMed Europe PMC


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105872view04:48, 16 August 2019KhanspersModified description
105433view04:33, 8 August 2019KhanspersModified description
103010view15:20, 31 January 2019Mkutmonupdated outdated Ensembl identifier (ATRIP)
102151view19:01, 4 December 2018Khanspersupdated identifier for ATRIP
90121view04:33, 14 October 2016Khanspersupdated unconnected
89275view06:40, 29 August 2016Khansperslayout change etc
88959view21:29, 17 August 2016AAR&CoReduced White Space
88958view21:28, 17 August 2016AAR&CoAdded Steps of Complex Formation
88957view21:26, 17 August 2016AAR&CoPeriodical save, work in progress
88817view22:49, 14 August 2016AAR&CoOntology Term : 'DNA damage response pathway' added !
88816view22:48, 14 August 2016AAR&CoOntology Term : 'DNA replication pathway' added !
88815view22:48, 14 August 2016AAR&CoModified description
88808view22:29, 14 August 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
ATRGeneProductENSG00000175054 (Ensembl)
ATRIPGeneProductENSG00000164053 (Ensembl)
CHK1GeneProductENSG00000149554 (Ensembl)
HUS1GeneProductENSG00000136273 (Ensembl)
RAD1GeneProductENSG00000113456 (Ensembl)
RAD9AGeneProductENSG00000172613 (Ensembl)
RAD9BGeneProductENSG00000151164 (Ensembl)
RPAGeneProductENSG00000132383 (Ensembl)
TOPBP1GeneProductENSG00000163781 (Ensembl)

Annotated Interactions

No annotated interactions

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