ATR Signaling (Homo sapiens)

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1Origin Firing9-1-1 Complex3. Substrate PhosphorylationDNA1. ATR+ATRIP Recruitment2. 9-1-1 & TOPBP1 Recruitment and ATR ActivationReplisome StabilityCell Arrest CycleRAD1HUS1RAD9BRAD9ACHK1PPPRPAATRATRIPRPARPARPARPADNARPARPARPARPARPAATRATRIPDNARPARPARPARPARPAATRATRIPPTOPBP19-1-1 ComplexHUS1RAD9BRAD9ARAD1


This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress.

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Ontology Terms



  1. Nam EA, Cortez D; ''ATR signalling: more than meeting at the fork.''; Biochem J, 2011 PubMed Europe PMC


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103010view15:20, 31 January 2019Mkutmonupdated outdated Ensembl identifier (ATRIP)
102151view19:01, 4 December 2018Khanspersupdated identifier for ATRIP
90121view04:33, 14 October 2016Khanspersupdated unconnected
89275view06:40, 29 August 2016Khansperslayout change etc
88959view21:29, 17 August 2016AAR&CoReduced White Space
88958view21:28, 17 August 2016AAR&CoAdded Steps of Complex Formation
88957view21:26, 17 August 2016AAR&CoPeriodical save, work in progress
88817view22:49, 14 August 2016AAR&CoOntology Term : 'DNA damage response pathway' added !
88816view22:48, 14 August 2016AAR&CoOntology Term : 'DNA replication pathway' added !
88815view22:48, 14 August 2016AAR&CoModified description
88808view22:29, 14 August 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
ATRGeneProductENSG00000175054 (Ensembl)
ATRIPGeneProductENSG00000164053 (Ensembl)
CHK1GeneProductENSG00000149554 (Ensembl)
HUS1GeneProductENSG00000136273 (Ensembl)
RAD1GeneProductENSG00000113456 (Ensembl)
RAD9AGeneProductENSG00000172613 (Ensembl)
RAD9BGeneProductENSG00000151164 (Ensembl)
RPAGeneProductENSG00000132383 (Ensembl)
TOPBP1GeneProductENSG00000163781 (Ensembl)

Annotated Interactions

No annotated interactions

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