Regulation of Apoptosis by Parathyroid Hormone-related Protein (Homo sapiens)

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1BCL-2 familyGrowth Factor ReceptorsPI3-KGSK3ABCL2L13BOKIntegrin A6BCL2A1BAXBCL2L10Intracrine PTHrPsiRNA B4MYCBCL2L14BIDBCL2L15GSK3BIntegrin B4ApoptosisMCL-1BCL-2 familyAKT1siRNA A6BCL2L1BCL2BCL2L2BAK1BCL2L12


This pathway is based on Figure 8 of "Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling."(See Bibliography). Parathyroid Hormone-related Protein Regulates Cell Survival Pathways via Integrin alpha6beta4-mediated Activation of PI3-K/Akt Signaling Intracrine PTHrP inhibits apoptosis by activating the PI3-K/Akt pathway by increasing levels of integrin A6B4, which signals in harmony with growth factor receptors. The activation of Akt increases the ratio of anti-apoptosis members to pro-apoptosis members in the Bcl-2 Family. The activation of Akt deactivates GSK-3 which leads to higher levels of c-myc, therefore leading to lower levels of apoptosis. Overall, intracrine PTHrP has the effect of increased cell survival on C4-2 cells. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Bhatia V, Mula RV, Weigel NL, Falzon M; ''Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling.''; Mol Cancer Res, 2009 PubMed Europe PMC


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106498view21:45, 4 September 2019KhanspersModified description
105802view22:50, 15 August 2019KhanspersModified description
89397view19:40, 10 September 2016AlexanderPicoModified title
89270view23:14, 28 August 2016Khansperstypo
89269view23:13, 28 August 2016Khanspersupdated layout and added BCL2 family
89268view19:13, 27 August 2016Khanspersreplaced label with pathwat node
89267view19:12, 27 August 2016Khanspersunified gene size, updated RNA node color, replaced label with gene
89104view14:28, 22 August 2016EgonwOntology Term : 'regulatory pathway' added !
89065view06:55, 19 August 2016FehrhartModified description
89064view06:53, 19 August 2016Fehrhartfixed greek characters in title
89063view06:50, 19 August 2016FehrhartMinor cosmetic changes
88798view20:40, 14 August 2016AAR&CoModified description
88797view20:39, 14 August 2016AAR&CoModified description
88796view20:38, 14 August 2016AAR&CoModified description
88795view20:36, 14 August 2016AAR&CoModified description
88794view20:32, 14 August 2016AAR&CoOntology Term : 'prostate cancer' added !
88793view20:31, 14 August 2016AAR&CoFix unconnected lines
88792view20:30, 14 August 2016AAR&CoModify Datanode
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88779view19:54, 14 August 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
Apoptosis PathwayWP254 (WikiPathways)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL-2 familyGeneProduct
BCL2A1GeneProductENSG00000140379 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl) Increases the ratio of anti-apoptosis members to pro-apoptosis members.
BCL2L10GeneProductENSG00000137875 (Ensembl)
BCL2L12GeneProductENSG00000126453 (Ensembl)
BCL2L13GeneProductENSG00000099968 (Ensembl)
BCL2L14GeneProductENSG00000121380 (Ensembl)
BCL2L15GeneProductENSG00000188761 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BCL2L2GeneProductENSG00000129473 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BOKGeneProductENSG00000176720 (Ensembl)
GSK3AGeneProductENSG00000105723 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
Growth Factor ReceptorsGeneProduct
Integrin A6 GeneProductENSG00000091409 (Ensembl)
Integrin B4 GeneProductENSG00000132470 (Ensembl)
Intracrine PTHrP GeneProductENSG00000087494 (Ensembl)
MCL-1ProteinQ07820 (Uniprot-TrEMBL)
MYCGeneProductENSG00000136997 (Ensembl)
PI3-KGeneProductENSG00000105851 (Ensembl)
siRNA A6 RnaIdentifier not found
siRNA B4RnaIdentifier not found

Annotated Interactions

No annotated interactions

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