Toll-like Receptor Signaling related to MyD88 (Homo sapiens)

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This pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography). TLR and NFkB are important in inflammation in the body and in the cancerous cells. TLR signaling pathways are usually connected with MyD88 dependent pathways and MyD88 independent pathways. TLR pathways that involve MyD88 dependent pathways such as this one involve IRAK complexes. The finding of TLR or NFkB genes within the body usually correlates with breast cancer within the person. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Ontology Terms



  1. Resler AJ, Malone KE, Johnson LG, Malkki M, Petersdorf EW, McKnight B, Madeleine MM; ''Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.''; BMC Cancer, 2013 PubMed Europe PMC


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107438view06:58, 8 October 2019DeSlOntology Term : 'cancer' added !
107437view06:57, 8 October 2019DeSlOntology Term : 'cancer pathway' added !
107436view06:57, 8 October 2019DeSlOntology Term : 'immune response pathway' added !
107435view06:54, 8 October 2019DeSlModified title
105843view23:12, 15 August 2019KhanspersModified description
89945view14:11, 6 October 2016EgonwModified description
89752view00:05, 30 September 2016KhanspersModified title
89634view23:28, 21 September 2016Khansperschanged to humna based on lit ref
89633view23:22, 21 September 2016Khansperswork in progress
88838view15:19, 15 August 2016AAR&CoAdded Labels and groups
88455view17:17, 8 August 2016AAR&CoFix excess space
88219view00:46, 1 August 2016AAR&CoAdded Identifier
88218view00:44, 1 August 2016AAR&CoIdentifier Modified
87419view11:32, 22 July 2016MkutmonOntology Term : 'breast cancer pathway' added !
87418view11:31, 22 July 2016MkutmonOntology Term : 'disease pathway' added !
87417view11:31, 22 July 2016MkutmonOntology Term : 'Toll-like receptor signaling pathway' added !
87304view20:47, 20 July 2016EgonwMouse pathway? It's all mouse genes.
87288view18:46, 20 July 2016AAR&CoModified description
87287view18:27, 20 July 2016AAR&CoAdded Literature Reference
87286view17:42, 20 July 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
CHUKGeneProductENSG00000213341 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IRAK1GeneProductENSG00000184216 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
RELAGeneProduct5970 (Entrez Gene)
RELBGeneProduct5971 (Entrez Gene)
TBK1GeneProductENSG00000183735 (Ensembl)
TICAM1GeneProductENSG00000127666 (Ensembl)
TICAM2GeneProductENSG00000243414 (Ensembl)
TIRAPGeneProductENSG00000150455 (Ensembl)
TLR1GeneProductENSG00000174125 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR3GeneProductENSG00000164342 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR5GeneProductENSG00000187554 (Ensembl)
TLR6GeneProductENSG00000174130 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TLR9GeneProductENSG00000239732 (Ensembl)
TOLLIPGeneProductENSG00000078902 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
c-RELGeneProduct5966 (Entrez Gene)

Annotated Interactions

No annotated interactions

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