TLR4 Signaling and Tolerance (Homo sapiens)

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This pathway is based on the figure 2 of "Toll-like Receptors: Novel Pharmacological Targets for the Treatment of Neurological Diseases" and figure 2 of "Toll-like receptor and its roles in myocardial ischemic/reperfusion injury" (see bibliography). The Toll-like receptors are used by mammals to recognize pathogen-associated molecules such as the cell wall components. The activation of TLR4 causes a cell's inability to produce TNFa. TLR4 deals with MyD88 independent and dependent pathways, and due to LPS tolerant cells, inhibitors of the MyD88 dependent pathway are increased. TLR is important in the creation of protective immune responses to cancers, and the protection of brain tissue from injury. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Ontology Terms



  1. Fang Y, Hu J; ''Toll-like receptor and its roles in myocardial ischemic/reperfusion injury.''; Med Sci Monit, 2011 PubMed Europe PMC
  2. Marsh BJ, Stenzel-Poore MP; ''Toll-like receptors: novel pharmacological targets for the treatment of neurological diseases.''; Curr Opin Pharmacol, 2008 PubMed Europe PMC


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105835view23:09, 15 August 2019KhanspersModified description
90114view22:52, 13 October 2016Khanspersconnected line
90021view19:30, 8 October 2016AlexanderPicoModified description
89944view13:58, 6 October 2016EgonwModified description
89753view00:08, 30 September 2016KhanspersModified title
89736view23:31, 29 September 2016Khanspersrestored lost information
89735view23:23, 29 September 2016Khanspersconnected interactions
89640view22:51, 22 September 2016Khansperscleanup and added interaction coloring
88719view17:59, 12 August 2016AAR&CoAdded Data Node
88718view17:55, 12 August 2016AAR&CoOntology Term : 'neurological disorder disease pathway' added !
88717view17:54, 12 August 2016AAR&CoAdded New Data Nodes
88716view17:45, 12 August 2016AAR&CoPeriodical save, work in progress
88712view17:35, 12 August 2016AAR&CoPeriodical save, work in progress
88709view17:24, 12 August 2016AAR&CoPeriodical save, work in progress
88576view19:04, 11 August 2016Mkutmonfix unconnected lines
87411view11:29, 22 July 2016MkutmonOntology Term : 'regulatory pathway' added !
87285view17:14, 20 July 2016AAR&CoModified description
87210view14:15, 19 July 2016AAR&CoAdded details from another source and cited
87206view14:08, 19 July 2016AAR&CoPeriodical save, work in progress
87183view19:57, 18 July 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
IFNBGeneProductENSG00000171855 (Ensembl)
IKKaGeneProductO15111 (Uniprot-TrEMBL)
IKKbGeneProductO14920 (Uniprot-TrEMBL)
IL6GeneProductENSG00000136244 (Ensembl)
IRAK-MGeneProductQ9Y616 (Uniprot-TrEMBL)
IRAK1GeneProductENSG00000184216 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
IkBaGeneProductP25963 (Uniprot-TrEMBL)
IkkiGeneProductQ14164 (Uniprot-TrEMBL)
MALGeneProductP58753 (Uniprot-TrEMBL)
MYD88GeneProductENSG00000172936 (Ensembl)
NAP1GeneProductP10145 (Uniprot-TrEMBL)
NEMOGeneProductQ9Y6K9 (Uniprot-TrEMBL)
NFKBGeneProductENSG00000109320 (Ensembl) NFKB not specified
RIP1GeneProductQ13546 (Uniprot-TrEMBL)
SHIP1GeneProductQ92835 (Uniprot-TrEMBL)
TAB1GeneProductENSG00000100324 (Ensembl)
TAB2GeneProductENSG00000055208 (Ensembl)
TAK1GeneProductO43318 (Uniprot-TrEMBL)
TBK1GeneProductENSG00000183735 (Ensembl)
TIRAPGeneProductENSG00000150455 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TNFaGeneProductP01375 (Uniprot-TrEMBL)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TRAMGeneProductENSG00000067167 (Ensembl) TRAM not specified
TRIFGeneProductQ8IUC6 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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