Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling (Homo sapiens)

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1Skeletal muscle cellamino acidsTNFrecActRIIBJNKAMPKGSK3BAKT1S1NEBIntegrin B1IGF1recDEPTORFoxO IGF1NFKB1ILKSMAD2PLD1SMAD3AKT1MTORMAFbxPI3KTNFrecLC3PDK1PGC1MLST8IRS1EIF2B2PTENTNFAMPKActin polymerization& MyofibrillogenesisTWEAKmTORC1 complexS6KN-WASPProtein synthesisTNFMyostatin4EPBIGFBP5mTORC2 complexMURF1RPTORProtein degradationProtein synthesisMTORMLST8MAPKAP1RICTORMTOR


The signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth. The kinase Akt, or protein kinase B (PKB), is a central component in the pathway and is involved in both muscle synthesis, through mammalian target of rapmycin (mTOR) and glycogen synthase kinase 3B (GSK3B), and muscle degradation, through the transcription factors of the FoxO family. The pathway also involves several feedback loops such as the negative feedback of S6K, phosphorylated by mTORC1, which inhibits IRS, or the positive feedback of mTORC2, which is necessary to maximize the activation of Akt. A variety of other factors and pathways also influence the IGF1-Akt signaling pathway at various points. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Schiaffino S, Mammucari C; ''Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.''; Skelet Muscle, 2011 PubMed Europe PMC Scholia


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121711view04:51, 26 February 2022EweitzRefine graphics
121710view04:51, 26 February 2022EweitzUse gene symbol
110688view13:38, 28 May 2020Fehrhartaddec complex nodes and IDs
110686view13:30, 28 May 2020Fehrhartreplaced mTORC1 and 2 complex labels with complexes
106412view21:57, 28 August 2019KhanspersModified description
105592view04:46, 10 August 2019KhanspersModified description
88165view08:32, 29 July 2016Mkutmonunconnected line
87350view20:50, 21 July 2016AlexanderPicoOntology Term : 'cell of skeletal muscle' added !
87349view20:50, 21 July 2016AlexanderPicoOntology Term : 'CL:0000188' removed !
87125view18:40, 18 July 2016AlexanderPicoOntology Term : 'cell of skeletal muscle' added !
87124view18:40, 18 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87123view18:39, 18 July 2016AlexanderPicoOntology Term : 'insulin-like growth factor signaling pathway' added !
87121view18:39, 18 July 2016AlexanderPicoNew pathway

External references


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NameTypeDatabase referenceComment
4EPBGeneProductENSG00000151247 (Ensembl) EIF4E
AKT1GeneProductENSG00000142208 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AMPKGeneProductENSG00000111725 (Ensembl)
ActRIIBGeneProductENSG00000114739 (Ensembl)
Actin polymerization & MyofibrillogenesisPathway
DEPTORGeneProductENSG00000155792 (Ensembl)
EIF2B2GeneProductENSG00000119718 (Ensembl)
FoxO GeneProductfamily of transcription factors
GSK3BGeneProductENSG00000082701 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IGF1rec GeneProductENSG00000140443 (Ensembl)
IGFBP5GeneProductENSG00000115461 (Ensembl) most important of grup of IGF binding proteins that inhibit binding of IGF1 to its receptor
ILKGeneProductENSG00000166333 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl) not sure, because also 2, 3, 4
Integrin B1GeneProductENSG00000150093 (Ensembl)
JNKProteinA0A087WVY6 (Uniprot-TrEMBL)
LC3GeneProductENSG00000101460 (Ensembl)
MAFbxGeneProductENSG00000156804 (Ensembl) FBXO32/atrogin-1
MAPKAP1GeneProductENSG00000119487 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
  • effect of AKT on MTOR is indirect
  • Part of two multiprotein complexes, TORC 1 and TORC 2
MURF1 GeneProductENSG00000158022 (Ensembl) TRIM63
MyostatinGeneProductENSG00000138379 (Ensembl)
N-WASPGeneProductENSG00000106299 (Ensembl)
NEBGeneProductENSG00000183091 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PGC1 GeneProductENSG00000109819 (Ensembl)
PI3KGeneProductENSG00000105851 (Ensembl) phosphatidlinositol 3-kinase
PLD1GeneProductENSG00000075651 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
Protein degradation Pathway
Protein synthesisPathway
RICTORGeneProductENSG00000164327 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
S6KGeneProductENSG00000108443 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
TNFGeneProductENSG00000228978 (EcoGene)
TNFGeneProductENSG00000228978 (Ensembl)
TNFrecGeneProductENSG00000067182 (Ensembl)
TWEAKGeneProductENSG00000125657 (Ensembl)
amino acids Metabolite33709 (ChEBI)
mTORC1 complexComplexCPX-503 (Complex Portal)
mTORC2 complexComplexCPX-4402 (Complex Portal)

Annotated Interactions

No annotated interactions

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