Myometrial Relaxation and Contraction Pathways (Mus musculus)

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1-3Pi + Adenylyl CyclasesCa2+NOPredicted Cxn43Ets complexMg2+Pathways of Myometrial ContractionPKCRGSGbgMyometrial ContractionAdenylyl CyclasesCalcium InfluxSRTR Phospholipase-CPKC inhibitor 1Phospholipase-CMAPKTranscription FactorsPTranscriptional RegulationAP-1 complexTRCamk2TRLPANa+Camk2NucleusRegulators of G-proteinsignaling (RGS)Cell GrowthIP3Pge2Activation via CRH and cAMPPip2Myometrial RelaxationPKCIGFBPIGFBPCalcium MobilizationNa+Predicted OT-RGbgPKC inhibitor 1Pathways of Myometrial RelaxationGbgCa2+DAGRamp1Cald1Crhr1ADPPlcb3GnaqGrk5Igfbp6PrkcgCorinRgs5PkiaRxfp2Gng2YwhaeRyr1Atf3Lpar1Gng11Gng13CNN2Rgs9Cyclic AMPMylk2Grk4Ramp2Gng4Gpr182Rgs16Rgs19Prkar1aArrb2ATPGng12OxtrOxtrIl1bPlcd1Gng8FosAtf5CrhAdcy9Gng3DgkzCrcpActg1Plcg2Adcy2Arrb1Rgs3Nfkb1PRKACAGrk4Itpr1Cnn1Igfbp2Cyclic 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 GMPPrkceCALM2Gng5ActbRgs10CalcaIl6Gabpa


Description

This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial muscle cells or act upon the myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gestation. These signaling events act to suppress coordinated contractions to prevent the early onset of labor at term, largely via activation of the adenylyl-cyclase thrhough G-protein coupled receptors. On the right side of this pathway are signaling componets involved in the activation of uterine contractions at labor, in particular, activation of calcium mobilization via Oxytocin mediated binding to the Oxytocin G-protein coupled receptor. Additional genes implicated in this pathway, based on microarray expression profiling of gestation, term and postpartum of term mice are also included (e.g., Guca2b, Rdc1, Edg2) have also been included. For a detailed description of this pathway see: http://genomebiology.com/2005/6/2/R12.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP289 (r89548) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR; ''Identifying genetic networks underlying myometrial transition to labor.''; Genome Biol, 2005 PubMed Europe PMC
  2. Aggelidou E, Hillhouse EW, Grammatopoulos DK; ''Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC
  3. Méhats C, Tanguy G, Dallot E, Cabrol D, Ferré F, Leroy MJ; ''Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium?''; J Clin Endocrinol Metab, 2001 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106886view13:36, 17 September 2019MaintBotHMDB identifier normalization
95806view14:53, 19 January 2018MkutmonHomology conversion update
87897view12:53, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
72108view22:11, 24 October 2013AlexanderPicoupdating label: Prkcc to Prkcg
72046view16:46, 24 October 2013Mkutmonupdated annotations
69916view19:38, 11 July 2013MaintBotModified description
69913view19:37, 11 July 2013MaintBotupdating to 2013 schema
47969view13:36, 23 April 2012MartijnVanIerseladded cell
47968view13:34, 23 April 2012MartijnVanIersellayout, added nucleus
47772view05:36, 6 April 2012Khanspersupdated xref
41284view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
35258view20:16, 11 February 2010Thomasmoved references from comment to bibliography
34385view22:49, 9 December 2009MaintBotAutomatic update of empty xrefs
32693view23:21, 31 August 2009KhanspersAdded ATP xref
32692view23:20, 31 August 2009Khanspersadded xrefs
32417view17:07, 15 August 2009MaintBotFixed text labels
32074view13:37, 14 August 2009MaintBotFixed group labels
31445view21:08, 13 August 2009MaintBotFixed text labels
30819view23:57, 29 July 2009MaintBotConverted from Homo sapiens
21488view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:Smooth muscle contraction]] moved to [[Pathway:WP385]]: Moved to stable identifier
8398view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Smooth muscle contraction]] moved to [[Pathway:Mus musculus:Smooth muscle contraction]]: Renaming species
7816view16:19, 18 December 2007MaintBotfixed category names
7489view12:42, 4 November 2007MaintBotAdded categories to GPML
6495view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Smooth_muscle_contraction]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA2GeneProductNo homologues found for original id L:59
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
Ackr3GeneProductENSMUSG00000044337 (Ensembl)
  • PMID: 10614663
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:57007
Acta1GeneProductENSMUSG00000031972 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:58
ActbGeneProductENSMUSG00000029580 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:60
Actc1GeneProductENSMUSG00000068614 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:70
Actg1GeneProductENSMUSG00000062825 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:71
Adcy1GeneProductENSMUSG00000020431 (Ensembl)
  • CYA1 HUMAN
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:107
Adcy2GeneProductENSMUSG00000021536 (Ensembl)
  • There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:108
Adcy3GeneProductENSMUSG00000020654 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:109
Adcy4GeneProductENSMUSG00000022220 (Ensembl)
  • There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:196883
Adcy5GeneProductENSMUSG00000022840 (Ensembl)
  • There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:111
Adcy6GeneProductENSMUSG00000022994 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:112
Adcy7GeneProductENSMUSG00000031659 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:113
Adcy8GeneProductENSMUSG00000022376 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:114
Adcy9GeneProductENSMUSG00000005580 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:115
AdmGeneProductENSMUSG00000030790 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:133
Arrb1GeneProductENSMUSG00000018909 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:408
Arrb2GeneProductENSMUSG00000060216 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:409
Atf1GeneProductENSMUSG00000023027 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:466
Atf2GeneProductENSMUSG00000027104 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1386
Atf3GeneProductENSMUSG00000026628 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:467
Atf4GeneProductENSMUSG00000042406 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:468
Atf5GeneProductENSMUSG00000038539 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:22809
Atf6bGeneProductENSMUSG00000015461 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1388
Atp2a2GeneProductENSMUSG00000029467 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:488
Atp2a3GeneProductENSMUSG00000020788 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:489
CALM1GeneProductNo homologues found for original id L:801
CALM2GeneProductMultiple homologues found: En:ENSMUSG00000019370;En:ENSMUSG00000019370;
CNN2GeneProductNo homologues found for original id L:1265
Cacnb3GeneProductENSMUSG00000003352 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:784
CalcaGeneProductENSMUSG00000030669 (Ensembl)
  • CRF HUMAN PMID: 11854458
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:796
Cald1GeneProductENSMUSG00000029761 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:800
Calm3GeneProductENSMUSG00000019370 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:808
Camk2aGeneProductENSMUSG00000024617 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:815
Camk2bGeneProductENSMUSG00000057897 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:816
Camk2dGeneProductENSMUSG00000053819 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:817
Camk2gGeneProductENSMUSG00000021820 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:818
Cnn1GeneProductENSMUSG00000001349 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1264
CorinGeneProductENSMUSG00000005220 (Ensembl)
  • MGI:97367
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10699
CrcpGeneProductENSMUSG00000025532 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:27297
Creb1GeneProductENSMUSG00000025958 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1385
Creb3GeneProductENSMUSG00000028466 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10488
CrhGeneProductENSMUSG00000049796 (Ensembl)
  • CRF HUMAN PMID: 11854458
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1392
Crhr1GeneProductENSMUSG00000018634 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1394
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
Cyclic GMPMetaboliteHMDB0001314 (HMDB)
DgkzGeneProductENSMUSG00000040479 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8525
Ets2GeneProductENSMUSG00000022895 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2114
FosGeneProductENSMUSG00000021250 (Ensembl)
  • PMID: 10218980 PMID: 7628395 [
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2353
GUCY2EGeneProductPMID: 11854458
GabpaGeneProductENSMUSG00000008976 (Ensembl)
  • Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun.

    Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS.

    PMID: 10218980
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2551
Gabpb1GeneProductENSMUSG00000027361 (Ensembl)
  • Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun.

    Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS.

    PMID: 10218980
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2553
Gja1GeneProductENSMUSG00000050953 (Ensembl)
  • Endogenous nitric oxide suppresses rat myometrial connexin 43 gap junction protein expression during pregnancy.

    Sladek SM, Westerhausen-Larson A, Roberts JM.

    PMID: 10377025
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2697
GnaqGeneProductENSMUSG00000024639 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2776
GnasGeneProductENSMUSG00000027523 (Ensembl)
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2778
Gnb1GeneProductENSMUSG00000029064 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2782
Gnb2GeneProductENSMUSG00000029713 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2783
Gnb3GeneProductENSMUSG00000023439 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2784
Gnb4GeneProductENSMUSG00000027669 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:59345
Gnb5GeneProductENSMUSG00000032192 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10681
Gng11GeneProductENSMUSG00000032766 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2791
Gng12GeneProductENSMUSG00000036402 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:55970
Gng13GeneProductENSMUSG00000025739 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:51764
Gng2GeneProductENSMUSG00000043004 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:54331
Gng3GeneProductENSMUSG00000071658 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2785
Gng4GeneProductENSMUSG00000021303 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2786
Gng5GeneProductENSMUSG00000068523 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2787
Gng7GeneProductENSMUSG00000048240 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2788
Gng8GeneProductENSMUSG00000063594 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:94235
Gngt1GeneProductENSMUSG00000029663 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2792
Gpr182GeneProductENSMUSG00000058396 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:11318
Grk4GeneProductENSMUSG00000052783 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2868
Grk5GeneProductENSMUSG00000003228 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2869
Grk6GeneProductENSMUSG00000074886 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2870
Gsto1GeneProductENSMUSG00000025068 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9446
Guca2aGeneProductENSMUSG00000023247 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2980
Guca2bGeneProductENSMUSG00000032978 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2981
Gucy1a3GeneProductENSMUSG00000033910 (Ensembl)
  • PMID: 11854458
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2982
Igfbp1GeneProductENSMUSG00000020429 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3484
Igfbp2GeneProductENSMUSG00000039323 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3485
Igfbp3GeneProductENSMUSG00000020427 (Ensembl)
  • Relaxin is a member of the Insulin Growth Factor family of proteins. IGFBP-3 binds IGFII preferentially. (SwissProt).
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3486
Igfbp4GeneProductENSMUSG00000017493 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3487
Igfbp5GeneProductENSMUSG00000026185 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3488
Igfbp6GeneProductENSMUSG00000023046 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3489
Il1bGeneProductENSMUSG00000027398 (Ensembl)
  • Structure, characterization, and expression of the rat oxytocin receptor gene.

    Rozen F, Russo C, Banville D, Zingg HH PMID: 7816817 quote: The presence of APREs in the OTR gene promoter suggests that the acute induction of OTR expression at the onset of parturition may be a phenomenon mechanistically similar to the fast induction of acute phase response genes. This notion is strengthened by the observation that the uterus is populated by macrophages and other specific lymphocytes (19,20). Specifically, at term, nearly half of the decidual cells are of bone marrow origin (20). IL-1beta released from macrophages stimulates the production and release of IL-6 by uterine stromal cells (21,22). Moreover, IL- is a central pathophysiological mediator of infection-induced premature delivery (23), and preterm delivery can be prevented by an IL-1 antagonist in mice (24). We speculate that under physiological as well as phathophysiological conditions, inflammatory cytokines are important inducers of labor and that this mechanism involves the cytokine-induced transcriptional activation of the OTR gene. :end quote

    19. Hunt, J.S. (1994) Biol. Reprod. 50, 461-466 20. Vince, G.S., et al. (1990) J. Immunol. Methods 132, 181-189. 21. Tabibzadeh, S. (1991) Endocr. Rev, 12, 272-290. 22. Dudley, D.Jl, et. Al. (1992) J. Clin. Endocrinol. Metab. 74, 884-889

    23. Romero, R., et. Al, Am. J. Obstet. Gynecol. 167, 863-872.
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3553
Il6GeneProductENSMUSG00000025746 (Ensembl)
  • Structure, characterization, and expression of the rat oxytocin receptor gene.

    Rozen F, Russo C, Banville D, Zingg HH PMID: 7816817 quote: The presence of APREs in the OTR gene promoter suggests that the acute induction of OTR expression at the onset of parturition may be a phenomenon mechanistically similar to the fast induction of acute phase response genes. This notion is strengthened by the observation that the uterus is populated by macrophages and other specific lymphocytes (19,20). Specifically, at term, nearly half of the decidual cells are of bone marrow origin (20). IL-1beta released from macrophages stimulates the production and release of IL-6 by uterine stromal cells (21,22). Moreover, IL- is a central pathophysiological mediator of infection-induced premature delivery (23), and preterm delivery can be prevented by an IL-1 antagonist in mice (24). We speculate that under physiological as well as phathophysiological conditions, inflammatory cytokines are important inducers of labor and that this mechanism involves the cytokine-induced transcriptional activation of the OTR gene. :end quote

    19. Hunt, J.S. (1994) Biol. Reprod. 50, 461-466 20. Vince, G.S., et al. (1990) J. Immunol. Methods 132, 181-189. 21. Tabibzadeh, S. (1991) Endocr. Rev, 12, 272-290. 22. Dudley, D.Jl, et. Al. (1992) J. Clin. Endocrinol. Metab. 74, 884-889

    23. Romero, R., et. Al, Am. J. Obstet. Gynecol. 167, 863-872.
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3569
Itpr1GeneProductENSMUSG00000030102 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3708
Itpr2GeneProductENSMUSG00000030287 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3709
Itpr3GeneProductENSMUSG00000042644 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3710
JunGeneProductENSMUSG00000052684 (Ensembl)
  • PMID: 10218980
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725
Lpar1GeneProductENSMUSG00000038668 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1902
MaffGeneProductENSMUSG00000042622 (Ensembl)
  • OMIM: Inoue et al. (1994) demonstrated that the US-2 element in the promoter of the human oxytocin receptor gene (OXTR; 167055) binds specifically nuclear proteins from human myometrium at parturition. Using the US-2 element in a yeast 1-hybrid system to screen a human myometrium cDNA library, Kimura et al. (1999) isolated a full-length cDNA encoding the homolog of chicken MafF. Human MAFF encodes a deduced 164-amino acid protein with a predicted molecular mass of 17.8 kD. Like other small MAF proteins (e.g., MAFG, 602020), it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. Northern blot analysis showed a strong 2.6-kb signal in mRNA from term myometrium and from kidney, but not from nonpregnant myometrium. The MAFF protein is also preferentially expressed in term myometrium. The authors concluded that MAFF plays a role in OXTR gene upregulation at term.
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:23764
Myl2GeneProductENSMUSG00000013936 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4633
Myl4GeneProductENSMUSG00000061086 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4635
Mylk2GeneProductENSMUSG00000027470 (Ensembl)
  • KML2 MOUSE
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:85366
Nfkb1GeneProductENSMUSG00000028163 (Ensembl)
  • Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene. Echetebu CO, Ali M, Izban MG, MacKay L, Garfield RE. PMID: 10421804
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4790
Nos1GeneProductENSMUSG00000029361 (Ensembl)
  • PMID: 11854458
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4842
Nos3GeneProductENSMUSG00000028978 (Ensembl)
  • PMID: 11854458
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4846
OxtGeneProductENSMUSG00000027301 (Ensembl)
  • MGI:97453
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5020
OxtrGeneProductENSMUSG00000049112 (Ensembl)
  • Sladek SM, Westerhausen-Larson A, Roberts JM. PMID: 10377025
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5021
PRKACAGeneProductNo homologues found for original id L:5566
Pde4bGeneProductENSMUSG00000028525 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5142
Pde4dGeneProductENSMUSG00000021699 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5144
PkiaGeneProductENSMUSG00000027499 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5569
PkibGeneProductENSMUSG00000019876 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5570
PkigGeneProductENSMUSG00000035268 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:11142
Plcb3GeneProductENSMUSG00000024960 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331
Plcd1GeneProductENSMUSG00000010660 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5333
Plcg1GeneProductENSMUSG00000016933 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5335
Plcg2GeneProductENSMUSG00000034330 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5336
PrkacbGeneProductENSMUSG00000005034 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5567
Prkar1aGeneProductENSMUSG00000020612 (Ensembl)
  • KAP0 HUMAN
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5573
Prkar1bGeneProductENSMUSG00000025855 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5575
Prkar2aGeneProductENSMUSG00000032601 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5576
Prkar2bGeneProductENSMUSG00000002997 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5577
PrkcaGeneProductENSMUSG00000050965 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5578
PrkcbGeneProductENSMUSG00000052889 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5579
PrkcdGeneProductENSMUSG00000021948 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5580
PrkceGeneProductENSMUSG00000045038 (Ensembl)
  • This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5581
PrkcgGeneProductENSMUSG00000078816 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5582
PrkchGeneProductENSMUSG00000021108 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5583
PrkcqGeneProductENSMUSG00000026778 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5588
PrkczGeneProductENSMUSG00000029053 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5590
Prkd1GeneProductENSMUSG00000002688 (Ensembl)
  • KPCM HUMAN
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5587
Ramp1GeneProductENSMUSG00000034353 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10267
Ramp2GeneProductENSMUSG00000001240 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10266
Ramp3GeneProductENSMUSG00000041046 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10268
Rgs10GeneProductENSMUSG00000030844 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6001
Rgs11GeneProductENSMUSG00000024186 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8786
Rgs14GeneProductENSMUSG00000052087 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10636
Rgs16GeneProductENSMUSG00000026475 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6004
Rgs17GeneProductENSMUSG00000019775 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:26575
Rgs18GeneProductENSMUSG00000026357 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:64407
Rgs19GeneProductENSMUSG00000002458 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10287
Rgs1GeneProductENSMUSG00000026358 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5996
Rgs20GeneProductENSMUSG00000002459 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8601
Rgs2GeneProductENSMUSG00000026360 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5997
Rgs3GeneProductENSMUSG00000059810 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5998
Rgs4GeneProductENSMUSG00000038530 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5999
Rgs5GeneProductENSMUSG00000026678 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8490
Rgs6GeneProductENSMUSG00000021219 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9628
Rgs7GeneProductENSMUSG00000026527 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6000
Rgs9GeneProductENSMUSG00000020599 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8787
Rln1GeneProductENSMUSG00000039097 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6013
Rxfp1GeneProductENSMUSG00000034009 (Ensembl)
  • PMID: 11809971
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:59350
Rxfp2GeneProductENSMUSG00000053368 (Ensembl)
  • PMID: 11809971 LGR8 MOUSE
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:122042
Ryr1GeneProductENSMUSG00000030592 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6261
Ryr2GeneProductENSMUSG00000021313 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6262
Ryr3GeneProductENSMUSG00000057378 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6263
SfnGeneProductENSMUSG00000047281 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2810
Slc8a1GeneProductENSMUSG00000054640 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6546
Sp1GeneProductENSMUSG00000001280 (Ensembl)
  • Promoter activity of the rat connexin 43 gene in NRK cells.

    Fernandez-Cobo M, Stewart D, Drujan D, De Maio A.

    Division of Pediatric Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

    PMID: 11255234
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6667
YwhabGeneProductENSMUSG00000018326 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7529
YwhaeGeneProductENSMUSG00000020849 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7531
YwhagGeneProductENSMUSG00000051391 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7532
YwhahGeneProductENSMUSG00000018965 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7533
YwhaqGeneProductENSMUSG00000076432 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10971
YwhazGeneProductENSMUSG00000022285 (Ensembl)
  • PMID: 9861170 PMID: 1317796
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7534

Annotated Interactions

No annotated interactions
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