MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ (Homo sapiens)

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This pathway is based on the figure 24.1 of "In Vitro Signaling by MAPK and NFκB Pathways Inhibited by Yersinia YopJ" (see bibliography). In the MAPK and NFkB pathways, YopJ is the main inhibitor of Raf and TRAF6, NIK, or MEKK1. YopJ, in the NFkB pathway, may inhibit TRAF6,NIK, or MEKK. The pathway is activated by the stimulus of the genes TRAF6, NIK, or MEKK1, or the stimulus on the interactions between Ras to Raf. In the NFkB pathway along with the MAPK pathway, with the use of activators such as kinases, G-proteins, and E3 ligases, are catalysts to initiate of signaling cascades with a concentrated lysate.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms



  1. Mukherjee S, Orth K; ''In vitro signaling by MAPK and NFkappaB pathways inhibited by Yersinia YopJ.''; Methods Enzymol, 2008 PubMed Europe PMC


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106636view21:00, 12 September 2019KhanspersModified description
105640view05:07, 10 August 2019KhanspersModified description
89943view13:57, 6 October 2016EgonwModified description
89751view00:03, 30 September 2016KhanspersModified title
89639view21:20, 22 September 2016Khanspersupdated incorrect lit ref, updated layout and some xrefs
88745view18:23, 14 August 2016AAR&CoOntology Term : 'bubonic plague' added !
88744view18:22, 14 August 2016AAR&CoAdded Data Nodes
88741view18:17, 14 August 2016AAR&CoPeriodical save, work in progress
88740view18:09, 14 August 2016AAR&CoEdited Interactions
88597view19:50, 11 August 2016Mkutmonfix unconnected lines
87410view11:28, 22 July 2016MkutmonOntology Term : 'mitogen activated protein kinase signaling pathway' added !
87273view16:29, 20 July 2016AAR&CoModified description
87099view15:33, 18 July 2016AAR&CoAdded Identifier
87098view15:27, 18 July 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
CHUKGeneProductENSG00000213341 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IkBGeneProductP25963 (Uniprot-TrEMBL) IkB Not Specified
MAPKGeneProductENSG00000100030 (Ensembl) MAPK not specified
MEKK1GeneProductQ13233 (Uniprot-TrEMBL)
MKKGeneProductP52564 (Uniprot-TrEMBL) MKK Not Specified
NFKBGeneProductENSG00000109320 (Ensembl) NFKB Not Specified
NIKGeneProductQ99558 (Uniprot-TrEMBL)
RAFGeneProductENSG00000132155 (Ensembl)
RasGeneProductENSG00000126458 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)

Annotated Interactions

No annotated interactions

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