Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)

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6, 9, 12, 13, 15...1014, 18, 41, 46, 6610, 25, 351, 522418, 4222, 23, 29, 41, 46...8, 671, 18, 528, 38, 39, 55521118, 19, 31, 35, 424, 7, 17, 502, 18, 33, 42, 46...2, 4, 7, 18, 50...18, 4225, 355, 37, 5822, 54, 57, 6518, 41, 42, 46, 668, 25, 35, 3934, 36, 42, 46, 6618, 42645220, 25, 3552144318, 42cytosolnucleoplasmPKNOX1 CTCF KDM6A H2BFS H2AFV NCOR1 HOXA2 bivalentchromatinHIST1H4 HIST1H2AD HIST2H2AA3 CTCF H2AFJ HOXB3 gene WDR5 H2AFJ H2AFZ HIST1H2AJ RBBP4 SUZ12 POLR2J HOXA3Me3K5-HIST2H3A HIST1H2BC HIST1H2BD POLR2F HIST3H2BB POLR2H EGR2 POLR2G H2AFV POLR2E HIST1H2BA Me3K5-H3F3A KMT2D HIST1H2BD H2AFJ RBBP5 H2AFZ Me3K-28-HIST2H3A POLR2G HIST1H2AD POLR2F HIST2H2AC HIST2H2BE HIST1H2AJ atRA:RARA,B:RXRA atactive HOXD4chromatinKMT2C Me3K-28-HIST1H3A POLR2G Me3K5-HIST1H3A HOXA1 gene HIST1H2BL EZH2 HIST2H2BE EED POLR2J EZH2 HIST1H2AC POLR2K atRA:RARA,B:RXRA atactive HOXA4chromatinHIST2H2AC HIST1H2BJ HIST1H2BJ HIST1H2BH H2AFZ POLR2F H2AFJ HIST1H2BB HIST1H2BO HIST1H2BD KMT2D HIST1H2AC NCOA6 HIST1H2BD HIST2H2AC HIST2H2BE RARA HIST1H2BA HIST3H2BB HIST1H2BH HOXB1:PBX1:PKNOX1and MEIS1 at activeHOXB1 chromatinMe3K-28-HIST1H3A RBBP5 HIST1H2BN Me3K5-HIST1H3A HIST2H2AC POLR2K HIST2H2BE H2AFX HIST1H4 HIST1H2BJ KDM6A Me3K5-H3F3A HIST1H2BD WDR5 HIST2H2AC PKNOX1 Me3K-28-H3F3A HIST1H4 HIST1H2BK HIST1H2BK HIST1H2AB H2AFB1 Me3K5-HIST2H3A HIST1H2BD HIST1H2AD NCOA3 HIST1H2AB H2AFB1 NCOA6 POLR2E HIST1H2BJ POLR2F POLR2K HIST1H2AD H2AFB1 POLR2D HIST1H2BL HIST1H2AB HIST1H2BJ Me3K5-HIST2H3A HIST1H2BO ASH2L H2AFZ HIST3H2BB HIST1H2BA POLR2G EGR2POLR2J H2AFX YY1 H2AFZ HIST1H2BO POLR2L EZH2 HOXD1 gene HOXD3 bivalentchromatinPOLR2I H2AFX HIST1H2AB HOXB1 HIST2H2AC POLR2A HIST1H4 ASH2L HIST1H2BH PBX1:PKNOX1Me3K5-HIST1H3A Me3K5-HIST2H3A MEIS1 H2AFX HIST1H2BL H2AFZ POLR2C POLR2E HIST1H2AJ HIST1H2BA H2AFV HIST1H2BC HIST1H2BC HIST1H2BC ZNF335 H2AFV POLR2G H2AFV H2AFB1 HIST1H2BD HIST1H2AB HIST1H2BH HOXA2 gene RARA EED HOXA2 geneHIST2H2BE POLR2B HIST1H2BH SUZ12 RARA HOXA1H2AFZ HIST3H2BB HIST2H2AA3 POLR2B HIST1H2BH HIST1H2BB KMT2D HIST1H2AD PAXIP1 HIST1H2AC H2AFJ HIST1H2AJ HIST1H2BK HIST1H2AJ HIST1H2AD HIST1H2BL HOXB4 gene H2AFV HIST1H2BJ H2AFX HIST1H2BK WDR5 POLR2G RARA Me3K5-HIST1H3A HIST3H2BB HIST1H2BA HIST1H2BM HIST1H2BA HIST1H2AJ H2AFJ HIST1H2BL HIST1H2BM POLR2E HIST1H2BH Me3K5-HIST1H3A HIST1H2AB HIST1H2BL NCOR1POLR2J POLR2J KDM6A H2AFZ HIST1H2BA RARA,B:RXRA at HOXD4bivalent chromatinHIST2H2AC HIST1H2BD ASH2L PCGF2Me3K5-HIST1H3A SUZ12 H2AFV HOXA1 mRNAASH2L HIST1H2AB HIST1H2BN POLR2K Me3K-28-H3F3A RARB HIST1H2BB POLR2L MEIS1 HIST1H2BO HIST1H2AD HIST1H2AC POLR2K HIST1H2BB HIST2H2AA3 HIST1H2BB H2AFJ RQCD1SUZ12 HIST3H2BB HOXB1 POLR2H PAXIP1 HIST2H2AC POLR2L POLR2B HIST1H2AJ RXRA HIST1H2AB HIST1H2AD RBBP5 HOXA4 geneHIST1H2BM EP300 HIST1H2BL ASH2L HIST1H2AJ EP300 Me3K5-HIST1H3A HIST1H2AB HIST1H2BA H2BFS HIST1H2AB HIST1H2AD HIST1H2AJ H2AFB1 RARA HOXA4 mRNAHIST1H2BO HIST1H2BM Me3K5-HIST1H3A HIST1H2BA HIST1H2BM Me3K5-HIST2H3A SUZ12 HIST1H2BJ HIST1H2AD PRC2 (EZH2) CoreHIST1H2AC EGR2KMT2D POLR2D NCOA3 POLR2J Me3K5-HIST1H3A HIST2H2AC Me3K5-HIST1H3A HIST1H2AC HOXD4 mRNAHIST1H2BL PKNOX1 RBBP7 HIST1H2AJ HIST1H4 POLR2D HIST1H2AJ EED HIST1H2BM HOXD1 gene HIST1H2AB POLR2L HOXB3 bivalentchromatinRBBP4 PAGR1 CNOT6:ZNF335POLR2E HIST1H2BH HOXB1Me3K5-HIST1H3A Me3K5-H3F3A AJUBAMe3K-28-HIST1H3A HIST1H2BC HIST1H2AC HIST1H2BO H2AFV HIST1H2BN HOXD4 gene HIST1H2BJ PKNOX1 H2AFJ POLR2G PAGR1 Me3K-28-H3F3A EED H2AFB1 HIST1H2BO HIST1H2BK H2AFV HIST1H2BK RBBP5 POLR2F HIST2H2BE HIST1H2AB H2AFZ PAGR1 HIST2H2AA3 Me3K5-H3F3A Me3K5-H3F3A HIST1H2BB HIST1H2AJ RARB HIST1H4 EED HIST1H2AB atRA Me3K-28-H3F3A HIST2H2AA3 HIST3H2BB HIST1H2BJ HIST2H2AA3 HIST1H2BM HIST1H2BA AJUBA HIST1H2AJ POLR2D NCOR1 POLR2I Me3K-28-H3F3A Me3K5-HIST1H3A HIST1H2AC HOXA1 geneHIST1H2BH POLR2K EED NCOA6 HIST1H2BO HOXB2 gene HIST1H4 POLR2F HIST1H2AC H2AFJ RARB KMT2C HIST2H2AC PKNOX1 RARA HIST1H2BN Me3K5-H3F3A POLR2J H2BFS RBBP7 HIST2H2BE PAGR1 HIST1H2AB HIST1H4 H2AFV HIST1H2BK HIST1H2BC H2AFV Me3K5-HIST1H3A HIST1H2BN HOXA3 geneHIST1H2AD H2AFJ Me3K-28-HIST1H3A HIST1H2AB HIST1H2BD RXRA HIST1H2BM KMT2C POLR2G HIST2H2AC Me3K5-HIST2H3A H2AFX H2AFZ KDM6A HIST2H2BE HIST1H2AB HIST3H2BB atRA HIST1H2AD WDR5 HIST2H2AC HIST2H2BE NCOA3 PAXIP1 POLR2I HIST1H2AD WDR5 HIST1H2BJ PAXIP1 RBBP5 KDM6A HIST1H2BL Me3K5-H3F3A HOXB1:PBX1:PKNOX1 atactive HOXA2chromatinPOLR2J POLR2L HIST1H2BB Me3K-28-HIST1H3A WDR5 HIST1H2BC H2AFX EP300 Me3K5-HIST1H3A RBBP5 RBBP5 POLR2B HIST1H2AJ HOXA2 gene SUZ12 H2AFB1 RARG HIST1H2AD HIST1H2BB HOXA4 gene HIST1H2AB RARB HIST1H2BJ Me3K5-HIST1H3A HIST1H2BC POLR2I H2AFZ H2AFZ POLR2D HIST1H2AJ HOXB2 mRNAHIST1H2BB Me3K5-H3F3A H2AFJ POLR2I PAGR1 atRA:RARA,G:RXRA atactive HOXB1chromatinKMT2D PAXIP1 HIST1H2BK ASH2L RBBP4 HIST1H4 HIST1H2BN RARA,B:RXRA at HOXB4bivalent chromatinMe3K5-H3F3A Me3K5-HIST2H3A POLR2A HIST1H2BM WDR5 KMT2D HIST1H2BK Me3K5-H3F3A KMT2C HIST1H2BB POLR2E WDR5 NCOR1 SUZ12 POLR2C HIST1H2BD HIST1H2AD Me3K5-HIST2H3A ASH2L HOXA1 gene Me3K-28-H3F3A HIST1H2BH H2AFJ PAX6HIST1H2BC PBX1 HOXD4 gene HIST1H2BK HIST2H2BE POLR2I HIST1H2BB HIST3H2BB POLR2I POLR2H H2BFS Me3K5-HIST1H3A HIST1H2BK RXRA HIST1H2AC HIST1H2BK H2AFZ HIST1H2BN H2AFB1 HIST1H2BD POLR2E Me3K-28-H3F3A HDAC3H2AFX H2AFV HIST1H2BC Me3K5-H3F3A ASH2L H2AFB1 H2AFZ HIST1H2AC POLR2D POLR2B POLR2A Me3K5-HIST2H3A RBBP7 POLR2A HOXB4 mRNANCOA6 HIST1H2BJ H2AFJ HIST1H2BL POLR2C HIST1H2AB HIST1H2AB H2BFS PBX1 POLR2A RARA H2AFX HOXB3 activechromatinMe3K5-HIST2H3A POLR2C HIST1H2BA HIST1H2BK HIST2H2BE HIST1H2BH HIST1H2BC EZH2 Me3K5-H3F3A HIST1H2AC HIST2H2BE POLR2G HIST1H2BD HIST2H2BE HIST1H2BJ H2BFS HIST1H4 HOXD3 mRNAHIST1H2BK HIST1H2BO H2BFS HIST1H2BJ Me3K5-H3F3A RBBP5 MEIS1 HIST2H2AC HIST1H2BO HIST1H2BM ASH2L HIST1H2BL EZH2 Me3K5-HIST1H3A H2BFS NCOA3 HIST2H2AC POLR2B HIST1H2AB HIST1H2BM HIST1H2AJ H2AFB1 HIST1H2BD HOXC4 geneMe3K5-HIST2H3A HIST3H2BB H2AFV HIST1H4 Me3K5-H3F3A HIST1H2BJ HIST2H2AC HIST1H2BN HIST1H2BN POLR2K POLR2H PAXIP1 HIST2H2AC HIST2H2AC HIST1H2BK H2AFX H2AFX HIST2H2BE HIST1H4 HIST1H2AB HIST1H4 KDM6A HIST1H2BD RBBP4 POLR2D POLR2L HIST1H2BJ HIST1H2BA HIST1H2BA Me3K5-H3F3A PAGR1 HIST1H2AJ SUZ12 HIST1H2BN H2BFS HIST1H2BH HIST1H2AC HIST1H2BM HIST1H2BJ HIST1H2AC KDM6A POLR2F POLR2D RXRA H2AFV HOXA3 activechromatinRARA Me3K5-H3F3A HIST1H2BC H2BFS H2AFJ HOXA4HIST1H2BO POLR2E EZH2 HIST1H2AB HIST1H2BM HIST1H2AB HIST1H2BB HIST1H2BL HIST1H2BK H2AFB1 HIST1H2BA HIST1H2AD Me3K5-HIST2H3A NCOA6 H2AFJ POLR2E HIST1H2BK HIST1H2BD H2AFX HIST1H2BM HIST1H2AJ H2AFJ NCOA6 POLR2C HOXA3 bivalentchromatinPOLR2B PAXIP1 HIST2H2AA3 POLR2C RBBP4 PKNOX1 Me3K-28-HIST2H3A H2BFS HOXB3 gene POLR2D HIST1H2BL HIST1H2BM HIST1H2AC EED HIST3H2BB Me3K-28-HIST2H3A HOXA4 gene HIST2H2AC H2AFV atRA KDM6A H2AFV POLR2B HIST1H4 HIST1H2BN HIST1H2BM HIST1H2BA RBBP5 HOXA2 gene POLR2L H2AFZ HIST1H4 HIST1H2BN POLR2H HIST2H2AA3 EZH2 HIST2H2AA3 NCOR1 RBBP4 HIST1H2BM HIST1H2BC HIST2H2AA3 HIST1H2BC HIST1H2AB HOXD4 geneMe3K-28-HIST2H3A HIST1H2AB HIST1H2BK HIST2H2AC HIST1H2BB HOXD1 bivalentchromatinHIST1H2AJ HIST1H2BD HIST2H2BE POLR2J HIST1H2BD HIST3H2BB Me3K5-H3F3A H2AFV POLR2E POLR2K HIST3H2BB HIST3H2BB RARB POLR2C HIST1H2BM HIST1H2AC HIST1H2BL KMT2C PAXIP1 RBBP7 HIST1H2AC HIST1H2BD Me3K5-H3F3A PAGR1 H2AFX RBBP4 WDR5 POLR2G HIST1H2AB KMT2C POLR2C H2AFJ PAXIP1 HIST1H2BJ POLR2H HIST3H2BB HIST1H2BM H2AFX HIST1H2BD POLR2G HIST1H2BB HIST2H2AC Me3K-28-H3F3A HIST3H2BB HIST1H2BH HIST1H2BN H2AFX HIST1H2BL HIST3H2BB Me3K-28-HIST1H3A Me3K5-HIST1H3A HOXB2 gene HIST1H2BN EZH2 H2AFZ HIST1H2BO HIST1H2AD HIST2H2AC PAGR1 EP300 Me3K5-HIST1H3A KMT2C HIST1H2BH H2AFJ H2AFZ HIST1H2AC HIST1H2BM HIST1H2BJ HIST1H2BK POLR2A POLR2E PAXIP1 NCOA6 HIST1H2BC HIST1H2BC NCOA6 HIST1H2BN HIST1H4 POLR2K ASH2L HIST1H2BH Me3K5-HIST1H3A PBX1 Me3K5-HIST1H3A RBBP4 EZH2 POLR2F EGR2 at active HOXB2chromatinHIST1H4 HIST1H2BC Me3K-28-HIST2H3A PAXIP1 POLR2D RBBP5 POLR2I HIST1H2BD RXRA HIST1H2BO H2BFS HIST1H2BD RBBP5 HIST1H2BM CNOT6 RBBP7 POLR2G HOXB4 geneHOXD1WDR5 HIST1H2AJ HIST1H2BJ HIST1H2AJ Me3K5-HIST2H3A KDM6A HIST1H2BB Me3K5-HIST1H3A HIST1H2BA ASH2L HIST1H2BC SUZ12 HIST1H2AJ HIST2H2BE Me3K5-H3F3A HOXB1 Me3K-28-HIST1H3A H2AFZ HIST2H2BE H2BFS SUZ12 HIST2H2BE H2AFV POLR2K Me3K5-HIST2H3A HIST1H2BO NCOA6 MLL2,3 complexPOLR2F HIST1H2BH HIST2H2BE HIST1H2BN HIST1H2AD POLR2H HIST1H2AC HIST1H2BC JUNHIST1H2BM HIST1H2BH POLR2B POLR2C ASH2L HIST1H4 HIST1H2AB HIST1H2BK POLR2D H2BFS HIST2H2AC H2AFB1 H2AFB1 HIST1H2AJ HIST2H2AC WDR5 SUZ12 Me3K5-HIST1H3A POLR2F ASH2L HIST1H2BM HIST1H2AD EGR2 at active HOXA2chromatinHIST1H2BJ H2AFJ HIST1H2BN KDM6A H2AFX HIST2H2AA3 HIST1H4 H2AFV H2AFV H2BFS Me3K-28-HIST1H3A HIST1H2BA H2AFZ HIST2H2AC HIST1H2BJ HIST1H2AJ NCOR1 HIST1H2BC H2AFB1 HIST1H2BN Me3K-28-H3F3A EED H2AFX H2BFS HIST2H2BE POLR2K HIST1H2BO PBX1 KDM6A POLR2I WDR5 HOXC4 activechromatinHOXB1 gene RARA,G:RXRA at HOXA1bivalent chromatinH2AFV H2AFZ HIST1H2AJ HIST1H2AC HIST1H2BB HIST1H2BA HIST1H2BC HOXB4POLR2L HIST3H2BB HIST1H2BB NCOA6 RXRA PAGR1 H2AFB1 KMT2D H2AFX RARA,B:RXRA at HOXA4bivalent chromatinHIST1H2BD H2AFX HIST1H2BL EED POLR2J H2AFJ Me3K5-H3F3A HIST1H2BD H2AFZ HOXB3 geneHIST1H2BK HIST1H2BM POLR2J HIST1H2BO HIST1H2BJ HIST2H2BE POLR2B HIST1H2AC POLR2A POLR2D H2AFJ HIST1H2BA HIST1H2AB PAXIP1 POLR2A KDM6A HIST1H2BA KMT2D POLR2A Me3K5-HIST2H3A RBBP4 HOXA2 activechromatinHIST1H2AC H2AFJ HIST1H2BN H2BFS HIST1H2BB HIST1H2BL HIST1H2BH HIST1H2AJ PBX1 PBX1 HIST1H2AC POLR2H KMT2D POLR2G POLR2B HIST1H4 WDR5 POLR2A POLR2L HIST2H2AA3 HOXB4 gene H2AFB1 WDR5 H2AFB1 RXRA HIST1H2BL POLR2H Me3K5-H3F3A NCOA6 EZH2 PBX1 HOXB1 gene RARA HIST3H2BB H2BFS HIST2H2AA3 HIST1H2BA HOXB3PAXIP1 H2AFV POLR2C HOXB2POLR2H HIST1H2BA RXRA MEIS1HIST1H2BH HIST1H2AJ HIST1H2BO HOXD4HIST1H2BB KMT2D NCOA6 HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatinRXRA HDAC3 RBBP7 PAGR1 RBBP4 PAX6 HIST1H2BC HIST2H2AA3 PAGR1 EED EGR2 H2BFS KMT2C HIST2H2BE Me3K5-HIST1H3A HIST2H2AA3 RBBP7 RBBP4 HIST1H2BC HIST1H2BL HIST1H2BO Me3K-28-HIST2H3A HOXD3 gene HIST1H2BH CREBBP HIST1H2AC H2AFB1 POLR2I HOXA2 gene HIST1H2BN HIST1H2AJ HIST2H2AC RBBP5 HOXA3 gene atRAHIST3H2BB HIST1H2BM HIST1H2BL POLR2K HIST1H2BL H2BFS Me3K5-HIST2H3A Me3K5-HIST2H3A KMT2D RBBP7 H2AFJ NCOA6 EZH2 H2AFV PBX1:PKNOX1H2AFZ POLR2H HIST1H2AD HIST1H2AC Me3K5-HIST2H3A EED HIST1H2BB HOXD3 activechromatinMe3K5-H3F3A HIST1H2BD Me3K5-HIST2H3A HIST1H2BC EZH2 HIST1H2BD Me3K5-HIST2H3A H2AFZ HIST3H2BB H2AFB1 H2AFX POLR2C HIST1H2BK YY1 H2AFZ HOXA2 mRNARARG MAFB PAGR1 H2AFZ PAXIP1 NCOA6 NCOA3 Me3K-28-HIST1H3A HIST2H2BE HOXB1 mRNAHIST1H2AC RNA Polymerase IIholoenzyme complex(generic)HIST1H2BL HIST1H2AJ CTCF POLR2I HIST2H2BE RBBP5 POLR2B H2AFJ HIST1H2BN HIST1H2BN PIAS2HIST1H2BB HIST2H2AA3 HIST3H2BB HIST2H2BE HIST1H4 HIST2H2BE NCOA6 H2AFB1 Me3K-28-HIST2H3A POLR2L Me3K-28-H3F3A atRA:RARA,G:RXRA atactive HOXA1chromatinMAFB:JUN and EGR2 atactive HOXB3chromatinMe3K-28-HIST2H3A H2AFB1 H2AFJ RBBP7 HIST1H2BH HIST2H2AC POLR2D H2AFB1 H2AFX HIST1H2BL HIST2H2AC POLR2B HOXC4 bivalentchromatinPOLR2F HIST1H2AD HIST1H2BC EGR2 KMT2C EZH2 POLR2H H2AFV HOXC4 gene HIST2H2AA3 POLR2J H2AFJ WDR5 atRA H2AFX HIST1H2BB atRA Me3K-28-HIST2H3A POLR2D HIST1H2AC POLR2K HIST1H2BA POLR2I