Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none cytosolnucleoplasmMLL2,3 complexRARA,G:RXRA at HOXA1bivalent chromatinRNA Polymerase IIholoenzyme complex(generic)NCOA3EP300atRAatRA:RARA,G:RXRA atactive HOXA1chromatinPRC2 (EZH2) CoreNCOR1HOXA1 mRNAHOXA1RARA,G:RXRA at HOXB1bivalent chromatinatRA:RARA,G:RXRA atactive HOXB1chromatinHOXB1 mRNAHOXB1HOXD1 bivalentchromatinHOXD1 activechromatinHOXD1 mRNAHOXD1HOXA2 bivalentchromatinEGR2EGR2 at active HOXA2chromatinHOXB1:PBX1:PKNOX1 atactive HOXA2chromatinHOXA2 mRNAHOXA2HOXB2 bivalentchromatinEGR2 at active HOXB2chromatinHOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatinHOXB2 mRNAHOXB2HOXA3 bivalentchromatinMAFBMAFB,HOXB1:PBX1:PKNOX1at active HOXA3chromatinHOXA3 mRNAHOXA3HOXB3 bivalentchromatinJUNMAFB:JUN and EGR2 atactive HOXB3chromatinHOXB3 mRNAHOXB3HOXD3 bivalentchromatinHOXD3 activechromatinHOXD3 mRNAHOXD3RARA,B:RXRA at HOXA4bivalent chromatinatRA:RARA,B:RXRA atactive HOXA4chromatinHOXA4 mRNAHOXA4RARA,B:RXRA at HOXB4bivalent chromatinatRA:RARA,B:RXRA atactive HOXB4chromatinHOXB4 mRNAHOXB4HOXC4 bivalentchromatinHOXC4 activechromatinHOXC4 mRNAHOXC4RARA,B:RXRA at HOXD4bivalent chromatinPAX6CREBBPatRA:RARA,B:RXRA atactive HOXD4chromatinPCGF2HOXD4 mRNAHOXD4HOXA1 geneHOXB1 geneHOXD1 geneHOXA2 geneHOXB2 geneHOXA3 geneHOXB3 geneHOXD3 geneHOXA4 geneHOXB4 geneHOXC4 geneHOXD4 geneAJUBAHDAC3EGR2EGR2PBX1:PKNOX1PBX1:PKNOX1,MEIS1HOXB1:PBX1:PKNOX1and MEIS1 at activeHOXB1 chromatinPBX1:PKNOX1PBX1:PKNOX1RQCD1CNOT6:ZNF335PIAS2HOXA2 activechromatinHOXB2 activechromatinHOXA3 activechromatinMEIS1HOXB3 activechromatinEGR2ASH2LNCOA6RBBP5WDR5KMT2CKMT2DPAGR1PAXIP1KDM6AMe3K-28-HIST2H3AMe3K-28-H3F3AMe3K-28-HIST1H3AMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AH2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSHIST1H4HOXA1 geneRXRARARARARGNCOR1EEDEZH2SUZ12RBBP4RBBP7AJUBAHDAC3POLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LPOLR2AHOXA1 geneRXRAatRARARARARGEP300NCOA3POLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LPOLR2AASH2LNCOA6RBBP5WDR5KMT2CKMT2DPAGR1PAXIP1KDM6AHIST1H4H2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AEEDEZH2SUZ12RBBP4RBBP7Me3K-28-HIST2H3AMe3K-28-H3F3AMe3K-28-HIST1H3AMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AH2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSHIST1H4RXRARARARARGNCOR1EEDEZH2SUZ12RBBP4RBBP7HOXB1 geneRXRAatRARARARARGEP300NCOA3POLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LPOLR2AHOXB1 geneHIST1H4H2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AASH2LNCOA6RBBP5WDR5KMT2CKMT2DPAGR1PAXIP1KDM6AMe3K-28-HIST2H3AMe3K-28-H3F3AMe3K-28-HIST1H3AMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AH2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSHIST1H4EEDEZH2SUZ12RBBP4RBBP7HOXD1 genePOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LPOLR2AHOXD1 geneHIST1H4H2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AMe3K-28-HIST2H3AMe3K-28-H3F3AMe3K-28-HIST1H3AMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AH2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSHIST1H4EEDEZH2SUZ12RBBP4RBBP7HOXA2 genePOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LPOLR2AHOXA2 geneEGR2HIST1H4H2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AASH2LNCOA6RBBP5WDR5KMT2CKMT2DPAGR1PAXIP1KDM6APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LPOLR2AHOXA2 geneHIST1H4H2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AASH2LNCOA6RBBP5WDR5KMT2CKMT2DPAGR1PAXIP1KDM6AHOXB1PBX1PKNOX1Me3K-28-HIST2H3AMe3K-28-H3F3AMe3K-28-HIST1H3AMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AH2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSHIST1H4EEDEZH2SUZ12RBBP4RBBP7HOXB2 genePOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LPOLR2AHOXB2 geneEGR2ASH2LNCOA6RBBP5WDR5KMT2CKMT2DPAGR1PAXIP1KDM6AHIST1H4H2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LPOLR2AHOXB2 geneHOXB1PBX1MEIS1PKNOX1ASH2LNCOA6RBBP5WDR5KMT2CKMT2DPAGR1PAXIP1KDM6AHIST1H4H2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BBHIST1H2BAHIST1H2BCHIST1H2BDHIST1H2BLHIST1H2BNHIST1H2BMHIST1H2BBHIST1H2BHHIST1H2BOHIST2H2BEHIST1H2BJH2BFSMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AMe3K-28-HIST2H3AMe3K-28-H3F3AMe3K-28-HIST1H3AMe3K5-H3F3AMe3K5-HIST1H3AMe3K5-HIST2H3AH2AFB1HIST1H2ABHIST1H2AJHIST1H2ADHIST1H2ACHIST2H2AA3HIST2H2ACH2AFJH2AFVH2AFXH2AFZHIST1H2BKHIST3H2BB