Fatty Acid Elongation, Saturated (Saccharomyces cerevisiae)

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palmitoyl-ACPtrans-delta2-enoyl-acyl-ACPacyl-ACPACP-SHACP-SHH2Oacyl(N+2)-ACPH+H2Omalonyl-ACPNADHPNADD-3-hydroxy-acyl-ACPNADPCO2H+beta-ketoacyl-ACPFAS1OAR1palmityl-CoAFAS2FAS2NADHFAS1CEM1


Description

Pyridoxal phosphate (PLP) is the active form of vitamin B6 and is a cofactor in many reactions of amino acid metabolism. Pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) are all forms of vitamin B6 that can be converted to PLP via the PLP salvage pathway. Most unicellular organisms and plants can synthesize PLP, whereas mammals cannot and require vitamin B6 in their diet. Thus far, three PLP biosynthetic pathways have been characterized: the de novo PLP biosynthesis pathway as characterized in Escherichia coli (CITS: [12686115]), the de novo PLP biosynthesis pathway as being studied in fungi (CITS: [15483325],[14764090]), and the PLP salvage pathway (CITS: [15483325], [17696614],[8764513],[9537380]). Saccharomyces cerevisiae synthesize PLP via the fungal type de novo PLP synthesis pathway and the PLP salvage pathway (CITS: [7896706], [17696614], [15483325], [14764090]). Extracellular PN, PL and PM are transported into the cell by Tpn1p, a member of the purine-cytosine permease family (CITS: [12649274]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

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Bibliography

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History

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CompareRevisionActionTimeUserComment
69867view17:46, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69636view20:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
67244view10:26, 26 June 2013Christine ChichesterOntology Term : 'fatty acid biosynthetic pathway' added !
41873view04:52, 2 March 2011MaintBotRemoved redundant pathway information and comments
36643view22:37, 9 April 2010MaintBotDescription and bibliography added from SGD
21478view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Fatty Acid Elongation Saturated]] moved to [[Pathway:WP380]]: Moved to stable identifier
12700view07:58, 17 May 2008MaintBotautomated metabolite conversion
8708view14:07, 7 January 2008MaintBotAdded to category $category
8706view14:07, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CEM1GeneProductS000000863 (SGD)
FAS1GeneProductS000001665 (SGD)
FAS2GeneProductS000006152 (SGD)
NADHMetabolite53-84-9 (CAS)
OAR1GeneProductS000001538 (SGD)
palmityl-CoAMetabolite1763-10-6 (CAS)

Annotated Interactions

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