Non-Oxidative Branch of the Pentose Pathway (Saccharomyces cerevisiae)

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1, 2NADPCO2NADPD-6-Phospho-glucono-delta-lactoneH+6-phospho-gluconateH2OH+GND2RPE1glyceraldehyde-3-phosphateribulose-5-phosphateTKL1xylulose-5-phosphatefructose-6-phosphateNADPHglyceraldehyde-3-phosphateTKL1TKL2xylulose degradationsedoheptulose-7-phosphateglucose-6-phosphateTAL1D-ribose-5-phosphateZWF1NADPHRKI1GND1erythrose-4-phosphate


The reactions of the non-oxidative branch of the pentose phosphate pathway are reversible and are important for generating ribose-5-phosphate, which is required for the biosynthesis of several biomolecules, including RNA and DNA. The flow of glucose 6-phosphate through glycolysis and the pentose phosphate pathway is linked through two enzymes of the non-oxidative branch of the pentose phosphate pathway, transketolase (Tkl1p and Tkl2p) and transaldolase (Tal1p). The ability of these enzymes to convert one type of sugar into another allows them to convert the byproduct of one pathway into the substrate of another pathway in order to meet the metabolic needs of the cell. For example, if the cell needs ribose 5-phosphate, glyceraldehyde 3-phosphate and fructose 6-phosphate will be converted to ribose 5-phosphate. If the cell needs NADPH or ATP more than ribose 5-phosphate, ribose 5-phosphate will be converted to glyceraldehyde 3-phosphate and fructose 6-phosphate for use by the oxidative branch of the pentose phosphate pathway or glycolysis, respectively.


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  1. Maaheimo H, Fiaux J, Cakar ZP, Bailey JE, Sauer U, Szyperski T; ''Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional (13)C labeling of common amino acids.''; Eur J Biochem, 2001 PubMed Europe PMC
  2. Blank LM, Kuepfer L, Sauer U; ''Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast.''; Genome Biol, 2005 PubMed Europe PMC


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96418view15:15, 13 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94662view11:36, 4 October 2017DeSlchanged label of ribose-5-phosphate to D-ribose-5-phosphate
94150view13:08, 24 August 2017DeSlAdded last missing IDs for metabolite nodes
94149view13:06, 24 August 2017DeSlModified description
94148view13:05, 24 August 2017DeSlConnected lines, changed textlabels to nodes, added IDs, changed faulty ID for sedoheptulose-7-phosphate, add literature refs.
89666view05:49, 24 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69866view17:28, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69618view20:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
67516view11:19, 26 June 2013DdiglesOntology Term : 'pentose phosphate pathway - non-oxidative phase' added !
41852view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
21476view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Pentose Pathway]] moved to [[Pathway:WP379]]: Moved to stable identifier
12804view08:03, 17 May 2008MaintBotautomated metabolite conversion
8864view14:10, 7 January 2008MaintBotAdded to category $category
8862view14:10, 7 January 2008M.BraymerUploaded new pathway

External references


View all...
NameTypeDatabase referenceComment
6-phospho-gluconateMetabolite42609787 (PubChem-compound)
CO2MetaboliteCHEBI:16526 (ChEBI)
D-6-Phospho-glucono-delta-lactoneMetaboliteCHEBI:16938 (ChEBI) ID is for closed form, should be open...
D-ribose-5-phosphateMetabolite3615-55-2 (CAS)
GND1GeneProductS000001226 (SGD)
GND2GeneProductS000003488 (SGD)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
NADPMetaboliteCHEBI:44409 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
RKI1GeneProductS000005621 (SGD)
RPE1GeneProductS000003657 (SGD)
TAL1GeneProductS000004346 (SGD)
TKL1GeneProductS000006278 (SGD)
TKL2GeneProductS000000321 (SGD)
ZWF1GeneProductS000005185 (SGD)
erythrose-4-phosphateMetaboliteCHEBI:48153 (ChEBI)
fructose-6-phosphateMetabolite26330295 (Chemspider)
glucose-6-phosphateMetabolite59-56-3 (CAS)
glyceraldehyde-3-phosphateMetabolite591-57-1 (CAS)
ribulose-5-phosphateMetabolite4151-19-3 (CAS)
sedoheptulose-7-phosphateMetabolite2646-35-7 (CAS)
xylulose degradationPathway
xylulose-5-phosphateMetaboliteCHEBI:27354 (ChEBI)

Annotated Interactions

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