Wnt Signaling Pathway NetPath (Rattus norvegicus)

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AcetylationD(Protein-protein interaction)DesumoylationDEndosomeCY->PMGolgi apparatusNUMolecule in the pathwayNucleusDDCY->NUProteolytic cleavageDDemethylationMethylationERCY->NUCY->PMAccession Number: NetPath 8; cellmap:8CY->PMGene SymbolPMGOLigandReceptorRecruitmentComplex formationExtracellularCY->NUPhosphorylationInhibitionMolecular AssociationControlPalmitoylationENEnzyme ComplexUbiquitinationCY->PMPlasma membraneCYCY->NUSumoylationDephosphorylationDDDeubiquitinationNU->CYGlycosylationPM->CYDeacetylationDECProteins in a complex interactionMitochondrionTranslocationAutophosphorylationCytoplasmActivationEndoplasmic reticulumMTCY->NUReaction through unknowm 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


Description

Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone.

Source: NethPath

Additional comments:

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
83028view02:01, 18 November 2015MkutmonFix outdated identifiers
71790view20:33, 17 October 2013MaintBotAutomated update of data sources
69401view19:00, 8 July 2013MaintBotUpdated to 2013 gpml schema
67760view11:59, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
41722view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
35028view09:17, 11 February 2010Thomasremoved old genmapp comments (moved to description)
35020view09:10, 11 February 2010ThomasModified description
34098view19:18, 9 December 2009MaintBotAutomatic update of empty xrefs
22594view13:42, 14 November 2008ThomasChanged pathway title (was duplicate of WP564)
21467view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Wnt NetPath 8]] moved to [[Pathway:WP375]]: Moved to stable identifier
8486view13:46, 7 January 2008MaintBot[[Pathway:Rat:Wnt NetPath 8]] moved to [[Pathway:Rattus norvegicus:Wnt NetPath 8]]: Renaming species
7859view16:23, 18 December 2007MaintBotfixed category names
7315view12:42, 4 November 2007MaintBotAdded categories to GPML
6609view22:20, 22 May 2007A.Pandeygpml file for [[Rat:Wnt_NetPath_8]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
ApcGeneProduct24205 (Entrez Gene)
Arrb1GeneProduct25387 (Entrez Gene)
Arrb2GeneProduct25388 (Entrez Gene)
Axin1GeneProduct
Axin1GeneProduct79257 (Entrez Gene)
Axin2GeneProduct29134 (Entrez Gene)
Bcl9GeneProductENSRNOG00000017516 (Ensembl)
Brd7GeneProduct361374 (Entrez Gene)
BtrcGeneProduct361765 (Entrez Gene)
CRYBB2GeneProduct25422 (Entrez Gene)
Camk2aGeneProduct25400 (Entrez Gene)
Camk2bGeneProduct24245 (Entrez Gene)
Camk2dGeneProduct24246 (Entrez Gene)
Camk2gGeneProduct171140 (Entrez Gene)
Ccnd1GeneProduct58919 (Entrez Gene)
Cdc25cGeneProduct307511 (Entrez Gene)
Cdc2aGeneProduct54237 (Entrez Gene)
Cdh1GeneProduct83502 (Entrez Gene)
Csnk1a1GeneProduct113927 (Entrez Gene)
Csnk1dGeneProduct64462 (Entrez Gene)
Csnk1eGeneProduct58822 (Entrez Gene)
Csnk2a1GeneProduct116549 (Entrez Gene)
Csnk2a2GeneProduct307641 (Entrez Gene)
Csnk2bGeneProduct81650 (Entrez Gene)
Ctbp1GeneProduct29382 (Entrez Gene)
Ctbp2GeneProduct81717 (Entrez Gene)
Ctnnb1GeneProduct84353 (Entrez Gene)
Cul1GeneProduct362356 (Entrez Gene)
Cxxc4GeneProduct83824 (Entrez Gene)
DVL2GeneProduct303251 (Entrez Gene)
Daam1GeneProduct314212 (Entrez Gene)
Dab2GeneProduct79128 (Entrez Gene)
Dkk1GeneProduct293897 (Entrez Gene)
Dlgh1GeneProduct25252 (Entrez Gene)
Dlgh2GeneProduct64053 (Entrez Gene)
Dlgh4GeneProduct29495 (Entrez Gene)
Dvl1GeneProduct83721 (Entrez Gene)
Dvl3GeneProduct303811 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
FRAT1GeneProduct
FRAT2GeneProduct
FZD7GeneProduct301440 (Entrez Gene)
Fhl2GeneProduct63839 (Entrez Gene)
Fzd1GeneProduct58868 (Entrez Gene)
Fzd2GeneProduct64512 (Entrez Gene)
Fzd4GeneProduct64558 (Entrez Gene)
Fzd5GeneProduct317674 (Entrez Gene)
Fzd6GeneProduct282581 (Entrez Gene)
Fzd9GeneProduct266608 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
HIPK2GeneProduct362342 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
JupGeneProduct81679 (Entrez Gene)
LOC500430GeneProduct500430 (Entrez Gene)
LOC503000GeneProduct503000 (Entrez Gene)
Lef1GeneProduct161452 (Entrez Gene)
Lrp1GeneProduct299858 (Entrez Gene)
Lrp5GeneProduct293649 (Entrez Gene)
Lrp6GeneProduct312781 (Entrez Gene)
MGC112790GeneProduct364754 (Entrez Gene)
MYBGeneProduct293405 (Entrez Gene)
Magi3GeneProduct245903 (Entrez Gene)
Map1bGeneProduct29456 (Entrez Gene)
Map3k7GeneProduct313121 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapk8ipGeneProduct116457 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
Mark2GeneProduct60328 (Entrez Gene)
Nkd1GeneProduct364952 (Entrez Gene)
Nr5a1GeneProduct83826 (Entrez Gene)
Pax2GeneProduct293992 (Entrez Gene)
Pias4GeneProduct362827 (Entrez Gene)
Pin1GeneProduct298696 (Entrez Gene)
Ppp2caGeneProduct24672 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
Prkcb1GeneProduct25023 (Entrez Gene)
PrkccGeneProduct24681 (Entrez Gene)
RGD1561602GeneProduct497961 (Entrez Gene)
Rac1GeneProduct363875 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
RhoaGeneProduct117273 (Entrez Gene)
Ror2GeneProduct306782 (Entrez Gene)
Runx2GeneProduct367218 (Entrez Gene)
Ruvbl1GeneProduct65137 (Entrez Gene)
SMT3H2GeneProduct
SOX1GeneProduct
SOX9GeneProduct140586 (Entrez Gene)
Sall1GeneProduct307740 (Entrez Gene)
Senp2GeneProduct78973 (Entrez Gene)
Sfrp1GeneProduct84402 (Entrez Gene)
Sfrp2GeneProduct310552 (Entrez Gene)
Skp1aGeneProduct287280 (Entrez Gene)
Smad3GeneProduct25631 (Entrez Gene)
Smad4GeneProductENSRNOG00000051965 (Ensembl)
Sumo1GeneProduct301442 (Entrez Gene)
TAX1BP3GeneProduct360564 (Entrez Gene)
TbpGeneProduct117526 (Entrez Gene)
Tcf4GeneProduct84382 (Entrez Gene)
Tcfap2aGeneProduct306862 (Entrez Gene)
Tcfe2aGeneProduct171046 (Entrez Gene)
Vangl2GeneProduct289229 (Entrez Gene)
Wnt1GeneProduct24881 (Entrez Gene)
Wnt2GeneProduct114487 (Entrez Gene)
Wnt3GeneProduct24882 (Entrez Gene)
Wnt3aGeneProduct303181 (Entrez Gene)
Wnt4GeneProduct84426 (Entrez Gene)
Wnt5aGeneProduct64566 (Entrez Gene)
Wnt7aGeneProduct114850 (Entrez Gene)

Annotated Interactions

No annotated interactions

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