Sphingolipid Metabolism (Saccharomyces cerevisiae)

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1-4C26 fatty acidL-serineInositol-P-ceramidephytoceramideLAC1YSR3LCB4ADPNADPHInositol phosphateADPPhytosphingosine-1-PMIPCLCB3dihydrosphingosineO2YSR3H2OCoenzyme AATPYDC1LAG1LCB1SUR2MIP2CInositol phosphateADPpalmitaldehydeLCB5TSC10GDP-mannosephosphoryl-ethanolamineLCB3LCB4NADPHIPT1ATPATP3-ketodihydrosphoingosineAUR1ATPYPC1CSG2dihydrosphingosine 1-phosphatePhytosphingosinepalmityl-CoASUR1ADPLCB5LCB2NADPC26 fatty acid


Description

Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannose-(inositol phosphate)2-ceramide (M(IP)2C)(CITS: [12069845]). In the yeast plasma membrane sphingolipids concentrate with ergosterol to form lipid rafts, specialized membrane microdomains implicated in a variety of cellular processes, including sorting of membrane proteins and lipids, as well as organizing and regulating signaling cascades (CITS: [12452424]). Intermediates in sphingolipid biosynthesis have been shown to play important roles as signaling molecules and growth regulators. Sphingolipid long chain bases (LCBs), dihydrosphingosine (DHS) and phytosphingosine (PHS), have been implicated as secondary messengers in signaling pathways that regulate heat stress response (CITS: [9405471])(CITS: [11967828]). Other intermediates, phytoceramide and long-chain base phosphates (LCBPs), have been shown to be components of the tightly-controlled ceramide/LCBP rheostat, which regulates cell growth (CITS: [12684378]). Since phosphoinositol-containing sphingolipids are unique to fungi, the sphingolipid biosynthesis pathway is considered a target for antifungal drugs (CITS: [9092515])(CITS: [15578972]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

Quality Tags

Ontology Terms

 

Bibliography

  1. Vallée B, Riezman H; ''Lip1p: a novel subunit of acyl-CoA ceramide synthase.''; EMBO J, 2005 PubMed Europe PMC
  2. Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T; ''Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae.''; Mol Cell Biol, 2001 PubMed Europe PMC
  3. Kihara A, Igarashi Y; ''Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release.''; J Biol Chem, 2002 PubMed Europe PMC
  4. Dickson RC, Lester RL; ''Sphingolipid functions in Saccharomyces cerevisiae.''; Biochim Biophys Acta, 2002 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107023view13:47, 17 September 2019MaintBotHMDB identifier normalization
89668view05:51, 24 September 2016EgonwFixed a weird char in a reference.
89667view05:50, 24 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
76472view23:39, 9 July 2014Khanspersconnected interactions, updated layout, added metabolites
70269view21:49, 15 July 2013MaintBotupdated to 2013 schema
69865view17:27, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67651view11:44, 26 June 2013DdiglesOntology Term : 'sphingolipid metabolic pathway' added !
41874view04:52, 2 March 2011MaintBotRemoved redundant pathway information and comments
36667view23:09, 9 April 2010MaintBot
36644view22:37, 9 April 2010MaintBotDescription and bibliography added from SGD
21457view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Sphingolipid Metabolism]] moved to [[Pathway:WP370]]: Moved to stable identifier
12847view08:05, 17 May 2008MaintBotautomated metabolite conversion
8927view14:12, 7 January 2008MaintBotAdded to category $category
8925view14:12, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-ketodihydrosphoingosineMetabolite
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
AUR1GeneProductS000001487 (SGD)
C26 fatty acidMetabolite
CSG2GeneProductS000000240 (SGD)
Coenzyme AMetabolite64885-97-8 (CAS)
GDP-mannoseMetabolite
H2OMetaboliteHMDB0002111 (HMDB)
IPT1GeneProductS000002479 (SGD)
Inositol phosphateMetaboliteHMDB0002985 (HMDB)
Inositol-P-ceramideMetaboliteHMDB0012237 (HMDB)
L-serineMetabolite56-45-1 (CAS)
LAC1GeneProductS000001491 (SGD)
LAG1GeneProductS000000995 (SGD)
LCB1GeneProductS000004911 (SGD)
LCB2GeneProductS000002469 (SGD)
LCB3GeneProductS000003670 (SGD)
LCB4GeneProductS000005697 (SGD)
LCB5GeneProductS000004250 (SGD)
MIP2CMetabolite
MIPCMetabolite
NADPHMetabolite53-57-6 (CAS)
NADPMetaboliteHMDB0000217 (HMDB)
O2MetaboliteHMDB0001377 (HMDB)
Phytosphingosine-1-PMetaboliteHMDB0012280 (HMDB)
PhytosphingosineMetaboliteHMDB0004610 (HMDB)
SUR1GeneProductS000005978 (SGD)
SUR2GeneProductS000002705 (SGD)
TSC10GeneProductS000000469 (SGD)
YDC1GeneProductS000006008 (SGD)
YPC1GeneProductS000000387 (SGD)
YSR3GeneProductS000001761 (SGD)
dihydrosphingosineMetabolite
dihydrosphingosine 1-phosphateMetabolite
palmitaldehydeMetabolite629-80-1 (CAS)
palmityl-CoAMetabolite1763-10-6 (CAS)
phosphoryl-ethanolamineMetabolite
phytoceramideMetabolite

Annotated Interactions

No annotated interactions
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