IL-1 Signaling Pathway (Mus musculus)

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InhibitionCY -> NUAcetylationPalmitoylationControlDesumoylationGolgi apparatusCY->EXReceptorDeacetylationActivationCY -> NURecruitmentLigandDSumoylationEnzyme complexProteins in a complex interactionDCY->EXDemethylationAutophosphorylationPhosphorylationMTUbiquitinationCytoplasmMolecular associationDENExtracellularDProteolytic cleavageDNucleusReaction through unknown mechanisms/molecules(Protein-protein interaction)DMolecule in the pathwayPMEndosomeAccession Number: NetPath 13ECPM -> CYCY -> NUGlycosylationNUPlasma membraneGODeubiquitinationMitochondriaTranslocationDephosphorylationMethylationPM -> CYDCYIl1rapSirpaPELI1Irak1Irak2MAPK1Irak4MAP3K14NFKBIAMAP2K1Irak1CHUKMAP3K7RELAIl1bIl1aTraf6Il1r1SirpaIl1rnIRAK3Il1aMAPK3CAPN1MAPK1IRAK4Irak1MAP3K7IP2NFKBIAPLCG1Il1r1Traf6MAP3K14PRKCZMAP3K7IP1MAP3K7IP1Il1aCHUKMAP3K7IP2NFKB1Traf6MAP3K7IP2MAP3K7MAP3K7MAP3K7IP2CAPNS1Irak1Irak1NFKBIBMAP3K7MAP3K7IP2Il1r1Gene SymbolIl1r2Il1r2PTPN11MAPK8Traf6CASP1SQSTM1IKBKAPIl1r2PTPN11RELAIl1bMAP3K7IP1Il1rapIl1rnMAP3K7IP2TOLLIPTraf6AKT1TOLLIPMAP3K7Myd88PELI1Traf6Irak1MAP3K7IRAK4Il1bIl1bIl1a


Description

The interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor, IL1R2. Upon binding to the ligands, interleukin-1 alpha or beta, IL1R1 interacts with IL-1 receptor accessory protein (IL1RAP) to activate the MAPK/JNK signaling modules. The MAPK pathway leads to activation of NFkB complex. As both IL-1 and TNF alpha stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_13

Comments

GenMAPP notes 
NetPath 13: IL-1 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
97052view15:15, 26 April 2018Olivier.traetsLine changes
69141view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67365view10:42, 26 June 2013Christine ChichesterOntology Term : 'interleukin-1 signaling pathway' added !
41331view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35778view06:16, 13 February 2010MaintBotAdded description
20755view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:IL-1 NetPath 13]] moved to [[Pathway:WP37]]: Moved to stable identifier
8160view13:46, 7 January 2008MaintBot[[Pathway:Mouse:IL-1 NetPath 13]] moved to [[Pathway:Mus musculus:IL-1 NetPath 13]]: Renaming species
7700view16:10, 18 December 2007MaintBotfixed category names
7239view12:41, 4 November 2007MaintBotAdded categories to GPML
6458view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:IL-1_NetPath_13]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct11651 (Entrez Gene)
CAPN1GeneProduct12333 (Entrez Gene)
CAPNS1GeneProduct12336 (Entrez Gene)
CASP1GeneProduct12362 (Entrez Gene)
CHUKGeneProduct12675 (Entrez Gene)
Gene SymbolGeneProduct
IKBKAPGeneProduct230233 (Entrez Gene)
IRAK3GeneProduct73914 (Entrez Gene)
IRAK4GeneProduct266632 (Entrez Gene)
Il1aGeneProduct16175 (Entrez Gene)
Il1aGeneProductENSMUSG00000027399 (Ensembl)
Il1bGeneProduct16176 (Entrez Gene)
Il1bGeneProductENSMUSG00000027398 (Ensembl)
Il1r1GeneProduct16177 (Entrez Gene)
Il1r2GeneProduct16178 (Entrez Gene)
Il1rapGeneProduct16180 (Entrez Gene)
Il1rnGeneProduct16181 (Entrez Gene)
Irak1GeneProduct16179 (Entrez Gene)
Irak2GeneProduct108960 (Entrez Gene)
Irak4GeneProduct266632 (Entrez Gene)
MAP2K1GeneProduct26395 (Entrez Gene)
MAP3K14GeneProduct53859 (Entrez Gene)
MAP3K7GeneProduct26409 (Entrez Gene)
MAP3K7IP1GeneProduct66513 (Entrez Gene)
MAP3K7IP2GeneProduct68652 (Entrez Gene)
MAPK1GeneProduct26413 (Entrez Gene)
MAPK3GeneProduct26417 (Entrez Gene)
MAPK8GeneProduct26419 (Entrez Gene)
Myd88GeneProduct17874 (Entrez Gene)
NFKB1GeneProduct18033 (Entrez Gene)
NFKBIAGeneProduct18035 (Entrez Gene)
NFKBIBGeneProduct18036 (Entrez Gene)
PELI1GeneProduct67245 (Entrez Gene)
PLCG1GeneProduct18803 (Entrez Gene)
PRKCZGeneProduct18762 (Entrez Gene)
PTPN11GeneProduct19247 (Entrez Gene)
RELAGeneProduct19697 (Entrez Gene)
SQSTM1GeneProduct18412 (Entrez Gene)
SirpaGeneProduct19261 (Entrez Gene)
TOLLIPGeneProduct54473 (Entrez Gene)
Traf6GeneProduct22034 (Entrez Gene)

Annotated Interactions

No annotated interactions
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