Pentose Phosphate Pathway (Saccharomyces cerevisiae)

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1[NOTE: TKL1, TKL2, Glyceraldehyde-3-phosphate,are duplicated for clarity, but are part of theD-6-Phospho-glucono-delta-lactonesame cytoplasmic pool.]Fructose-6-phosphate, and Xylulose-5-phosphate6-PhosphogluconateNADPHD-Ribose-5-PhosphateErythrose-4-phosphateTKL1TKL1GND1SOL3GND2TKL2SOL4Xylulose-5-phosphateGlucose-6-phosphateRibulose-5-phosphateSedoheptulose-7-phosphateTAL1H2ONADPH+Glyceraldehyde-3-phosphateRKI1Glyceraldehyde-3-phosphateZWF1RPE1Fructose-6-phosphateXylulose-5-phosphateNADPNADPHH+[CO2]Net Reaction Equation: 3 glucose 6-P + 6 NADP+ + 3H2O = 6 NADPH + 6 H+ + 3 CO2 + glyceraldehyde 3-P + 2 beta-D-fructose-6P


Description

The pentose phosphate pathway is important for generating NADPH, which is a source of reducing energy, as well as a variety of sugar molecules that are required for the biosynthesis of nucleic acids and amino acids. (CITS:[8929392])(CITS:[8910528])(CITS:[9813062])(CITS:[ 11298766])(CITS:[1628611])(CITS:[15960801])(CITS:[7916691])(CITS:[14690456]). This pathway is also important for protecting yeast from oxidative stress, since NADPH is an essential cofactor for glutathione- and thioredoxin-dependent enzymes that defend cells against oxidative damage (CITS:[8929392])(CITS:[8910528])(CITS:[11557322])(CITS:[16179340]). The pentose phosphate pathway is of industrial interest for the fermentation of xylose to ethanol (CITS:[11916674]). Xylose is the predominant sugar found in biomass such as agricultural wastes, wood, municipal solid wastes, and wastes from pulp and paper industries, and possibly could serve as a low-cost and abundant raw material for fuel ethanol production (CITS:[8534086]). Saccharomyces cerevisiae does not naturally metabolize xylose, but recombinant S. cerevisiae strains containing the xylose reductase and xylitol dehydrogenase genes from Pichia stipitis are able to metabolize xylose via the pentose phosphate pathway (CITS:[15630585])(CITS:[8534086]). Changes in the levels of enzymes in the pentose phosphate pathway effect the fitness, ethanol production, and amount of xylose metabolized by these recombinant xylose-utilizing strains. The pentose phosphate pathway is also of medical interest because mutations in the human homologs of some yeast pentose phosphate genes are associated with a variety of diseases. Zwf1p is homologus to human glucose-6-phosphate dehydrogenase (G6PD), which has been implicated in neonatal jaundice and haemolytic anemia. Sol3p and Sol4p have similarity to human PGLS, which is associated with 6- phosphogluconolactonase deficiency and may contribute to some forms of G6PD-associated hemolytic anemia (CITS:[10518023]). Sol3p and Sol4p also have similarity to human H6PD, which is associated with cortisone reductase deficiency (CITS:[10518023]). Gnd1p and Gnd2p have similarity to human PGD, mutation in which may also contribute to some forms of G6PD-associated hemolytic anemia (CITS:[10518023]). Tal1p is similar to human TALDO1, mutation in which has been reported to be associated with transaldolase deficiency and hepatosplenomegaly (CITS:[ 8300619]). Rki1p has similarity to human RPIA, which has been associated with ribose 5-phosphate isomerase deficiency, leukoencephalopathy and peripheral neuropathy (CITS:[16054529]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP notes 

Based on Glycolysis and Gluconeogenesis Pathways at SGD and on Kruckeberg, AL and Dickinson, JR (2004) Carbon Metabolism in The Metabolism and Molecular Physiology of Saccharomyces cerevisiae, Dickinson, JR and Schweizer, M, eds, CRC Press.

GenMAPP remarks 

Right click here for references

Quality Tags

Ontology Terms

 

Bibliography

  1. ''''; http://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PENTOSE-P-PWY&detail-level=2,

History

View all...
CompareRevisionActionTimeUserComment
96415view12:02, 13 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94661view11:34, 4 October 2017DeSlchanged label of ribose-5-phosphate to D-ribose-5-phosphate
94062view12:57, 17 August 2017DeSlAdded missing metabolite nodes, annotated all of the nodes.
94061view12:40, 17 August 2017DeSl2nd attempt; connected all interaction lines now; added IDs for 2 metabolites (previously text labels)
94060view12:11, 17 August 2017DeSlReverted to version '17:25, 11 July 2013' by DeSl
94059view11:38, 17 August 2017DeSlConnected several lines.
69863view17:25, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69645view20:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
67582view11:29, 26 June 2013DdiglesOntology Term : 'pentose phosphate pathway' added !
58988view19:35, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41883view04:52, 2 March 2011MaintBotRemoved redundant pathway information and comments
36610view22:30, 9 April 2010MaintBotDescription and bibliography added from SGD
29895view11:20, 9 June 2009Thomas
21455view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Pentose Phosphate Pathway]] moved to [[Pathway:WP369]]: Moved to stable identifier
12806view08:03, 17 May 2008MaintBotautomated metabolite conversion
10997view20:22, 2 March 2008MaintBotyeast id converter
8867view14:11, 7 January 2008MaintBotAdded to category $category
8865view14:10, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-PhosphogluconateMetaboliteCHEBI:48928 (ChEBI)
D-6-Phospho-glucono-delta-lactoneMetaboliteCHEBI:16938 (ChEBI)
D-Ribose-5-PhosphateMetabolite3615-55-2 (CAS)
Erythrose-4-phosphateMetabolite585-18-2 (CAS)
Fructose-6-phosphateMetabolite643-13-0 (CAS)
GND1GeneProductYHR183W (Ensembl)
GND2GeneProductYGR256W (Ensembl)
Glucose-6-phosphateMetabolite59-56-3 (CAS)
Glyceraldehyde-3-phosphateMetabolite591-57-1 (CAS)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
NADPMetaboliteCHEBI:44409 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
RKI1GeneProductYOR095C (Ensembl)
RPE1GeneProductYJL121C (Ensembl)
Ribulose-5-phosphateMetabolite4151-19-3 (CAS)
SOL3GeneProductYHR163W (Ensembl)
SOL4GeneProductYGR248W (Ensembl)
Sedoheptulose-7-phosphateMetabolite2646-35-7 (CAS)
TAL1GeneProductYLR354C (Ensembl)
TKL1GeneProductYPR074C (Ensembl)
TKL2GeneProductYBR117C (Ensembl)
Xylulose-5-phosphateMetabolite60802-29-1 (CAS)
ZWF1GeneProductYNL241C (Ensembl)
[CO2]MetaboliteCHEBI:16526 (ChEBI)

Annotated Interactions

No annotated interactions
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