BDNF-TrkB Signaling (Homo sapiens)

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Brain-derived neurotrophic factor (BDNF) is an important neurotrophin for the regulation of synaptic activity. BDNF-TrkB signaling, TrkB being the receptor of BDNF, is involved in transcription, translation, and trafficking of proteins in the various stages of synaptic development and evidence indicates that it also plays a significant role in synaptic plasticity, the ability of synapses to strengthen or weaken over time. Synaptic plasticity has been associated with learning and memory development. These functions are carried out through three pathways: mitogen-activated protein kinase (MAPK), phospholipase CG (PLC/PLCG), and phosphatidylinositol 3-kinase (PI3K). Pi3K and MAPK have crucial roles in the protein translation and transport caused by synaptic activity. PLCG regulates intracellular levels of Ca2+, which drives gene transcription through cyclic AMP. Evidence strongly indicates that abnormal levels of BDNF leads to significant developmental and neurodegenerative diseases by disrupting neural development and function. An understanding of how the BDNF-TrkB pathway regulates synaptic activity and plasticity is essential to an understanding of how we can effectively treat genetic disruptions of this pathway that lead to terrible neurodevelopmental diseases. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Yoshii A, Constantine-Paton M; ''Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease.''; Dev Neurobiol, 2010 PubMed Europe PMC Scholia


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106307view17:46, 20 August 2019KhanspersModified description
105538view06:05, 9 August 2019KhanspersModified description
94186view14:04, 25 August 2017Mkutmonadded missing metabolite identifier
89741view23:42, 29 September 2016KhanspersModified title
88594view19:41, 11 August 2016Mkutmonfix unconnected lines
87117view18:26, 18 July 2016AAR&CoReverted to version '01:18, 18 July 2016' by AAR&Co
87116view18:25, 18 July 2016AAR&CoReverted to version '13:09, 1 July 2016' by AAR&Co
87067view01:18, 18 July 2016AlexanderPicoOntology Term : 'neuron' added !
87066view01:18, 18 July 2016AlexanderPicoOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
87065view01:18, 18 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87064view01:17, 18 July 2016AlexanderPicoAdded cellular labels
87063view01:14, 18 July 2016AlexanderPicoSimplified into single diagram
86132view13:09, 1 July 2016AAR&CoModified description
86131view13:08, 1 July 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
4E-BP1GeneProductENSG00000187840 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
ARCGeneProductENSG00000198576 (Ensembl)
Adenyl Cyclase GeneProductENSG00000164742 (Ensembl)
BDNFGeneProductENSG00000176697 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CamMKIIIGeneProductENSG00000103319 (Ensembl)
DAGMetaboliteQ161466 (Wikidata) diacylglycerol
GAB1GeneProductENSG00000109458 (Ensembl)
GAB2GeneProductENSG00000033327 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
HOMERGeneProductENSG00000152413 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IP3Metabolite388562 (Chemspider) Inositol 1, 4, 5- triphosphate
KRASGeneProductENSG00000133703 (Ensembl)
MAPK/ErkGeneProductENSG00000100030 (Ensembl)
MEKGeneProductENSG00000169032 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
Mnk1GeneProductENSG00000079277 (Ensembl)
NMDARGeneProductENSG00000176884 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PI3K GeneProductENSG00000105851 (Ensembl)
PKCGeneProductprotein kinase C
PLCGGeneProductENSG00000124181 (Ensembl)
PSD95GeneProductENSG00000132535 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RskGeneProductENSG00000117676 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
TRPC3GeneProductENSG00000138741 (Ensembl)
TRPC6GeneProductENSG00000137672 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TrkBGeneProductENSG00000148053 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)
p70S6GeneProductENSG00000108443 (Ensembl)

Annotated Interactions

No annotated interactions

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