LncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)

From WikiPathways

Jump to: navigation, search
1Drug-resistantcancer cellsTransporterexpressionChemotherapyCell survivalImpaired drug expulsionHCC cellsHIF1ATP53Cell proliferationApoptosislinc-VLDLRWNT6AK126698G0/G1 cell cycle arrestp21P-gpMEG3HOTAIRlinc-RoRMRULUCA1Bcl-xlHypoxiaRecipient cellsEVsEV linc-RoREV linc-VLDLR


Description

LncRNA-mediated mechanisms of therapeutic resistance. Mechanisms of tumor cell resistance to chemotherapy or hypoxia involving lncRNA include modulation of drug transporters and elimination, survival signaling pathways, cell cycle progression and DNA repair, sensitization to apoptosis, and modulation of intercellular communication mediated by extracellular vesicles.

This pathway is based on Fig 6 from Parasramka et al: http://www.ncbi.nlm.nih.gov/pubmed/27013343

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Parasramka MA, Maji S, Matsuda A, Yan IK, Patel T; ''Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.''; Pharmacol Ther, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
108191view10:55, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106632view20:56, 12 September 2019KhanspersModified description
105511view06:02, 8 August 2019KhanspersModified description
96967view01:39, 24 April 2018AlexanderPicocondensed layout
87395view11:05, 22 July 2016MaintBotadded missing graphids
86056view23:01, 28 June 2016KhanspersModified description
86053view21:46, 28 June 2016KhanspersOntology Term : 'antineoplastic drug pathway' added !
86052view21:44, 28 June 2016KhanspersOntology Term : 'long non-coding RNA pathway' added !
86051view21:43, 28 June 2016KhanspersOntology Term : 'hepatocellular carcinoma' added !
86050view21:41, 28 June 2016Khanspersupdated data node color and type
86049view21:40, 28 June 2016KhanspersModified description
86048view21:39, 28 June 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AK126698RnaENSG00000203601 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
Bcl-xlGeneProductENSG00000171552 (Ensembl)
Cell proliferationPathway
EV linc-RoRRnaENSG00000258609 (Ensembl)
EV linc-VLDLRRna401491 (Entrez Gene)
G0/G1 cell cycle arrestPathway
HIF1AGeneProductENSG00000100644 (Ensembl)
HOTAIRRnaENSG00000228630 (Ensembl)
MEG3RnaENSG00000214548 (Ensembl)
MRULRna
P-gpGeneProductENSG00000085563 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
UCA1RnaENSG00000214049 (Ensembl)
WNT6GeneProductENSG00000115596 (Ensembl)
linc-RoRRnaENSG00000258609 (Ensembl)
linc-VLDLRRna401491 (Entrez Gene)
p21GeneProductENSG00000124762 (Ensembl)

Annotated Interactions

No annotated interactions

Personal tools