lncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)

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1HCC cellsChemotherapyDrug-resistantcancer cellsImpaired drug expulsionTransporterexpressionCell survivalWNT6G0/G1 cell cycle arrestBcl-xlUCA1AK126698ApoptosisHOTAIRTP53Cell proliferationp21HIF1AMRULMEG3linc-RoRlinc-VLDLRP-gpHypoxiaRecipient cellsEVsEV linc-RoREV linc-VLDLR


LncRNA-mediated mechanisms of therapeutic resistance. Mechanisms of tumor cell resistance to chemotherapy or hypoxia involving lncRNA include modulation of drug transporters and elimination, survival signaling pathways, cell cycle progression and DNA repair, sensitization to apoptosis, and modulation of intercellular communication mediated by extracellular vesicles.

This pathway is based on Fig 6 from Parasramka et al: http://www.ncbi.nlm.nih.gov/pubmed/27013343

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Parasramka MA, Maji S, Matsuda A, Yan IK, Patel T; ''Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.''; Pharmacol Ther, 2016 PubMed Europe PMC Scholia


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123394view06:24, 23 July 2022EgonwMade a pathway clickable
117771view13:56, 22 May 2021EweitzModified title
108191view10:55, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106632view20:56, 12 September 2019KhanspersModified description
105511view06:02, 8 August 2019KhanspersModified description
96967view01:39, 24 April 2018AlexanderPicocondensed layout
87395view11:05, 22 July 2016MaintBotadded missing graphids
86056view23:01, 28 June 2016KhanspersModified description
86053view21:46, 28 June 2016KhanspersOntology Term : 'antineoplastic drug pathway' added !
86052view21:44, 28 June 2016KhanspersOntology Term : 'long non-coding RNA pathway' added !
86051view21:43, 28 June 2016KhanspersOntology Term : 'hepatocellular carcinoma' added !
86050view21:41, 28 June 2016Khanspersupdated data node color and type
86049view21:40, 28 June 2016KhanspersModified description
86048view21:39, 28 June 2016KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
AK126698RnaENSG00000203601 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
Bcl-xlGeneProductENSG00000171552 (Ensembl)
Cell proliferationPathway
EV linc-RoRRnaENSG00000258609 (Ensembl)
EV linc-VLDLRRna401491 (Entrez Gene)
G0/G1 cell cycle arrestPathway
HIF1AGeneProductENSG00000100644 (Ensembl)
HOTAIRRnaENSG00000228630 (Ensembl)
MEG3RnaENSG00000214548 (Ensembl)
P-gpGeneProductENSG00000085563 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
UCA1RnaENSG00000214049 (Ensembl)
WNT6GeneProductENSG00000115596 (Ensembl)
linc-RoRRnaENSG00000258609 (Ensembl)
linc-VLDLRRna401491 (Entrez Gene)
p21GeneProductENSG00000124762 (Ensembl)

Annotated Interactions

No annotated interactions

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