Programmed Cell Death (Caenorhabditis elegans)

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34, 11ProgrammedCell Death9-1-1 complexPCD Signal:DNA damagePCD Signal:Somatic developmentPCD Signal: germlinedevelopmentcep-1mrt-2ced-4gld-1ape-1gld-3ced-9pax-2ced-13akt-1hus-1hpr-9clk-2egl-38fsn-1egl-1ced-3abl-197, 102185612


Programmed Cell Death pathway. Based on conference notes, european worm meeting 2004

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  1. Gao MX, Liao EH, Yu B, Wang Y, Zhen M, Derry WB; ''The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans.''; Cell Death Differ, 2008 PubMed Europe PMC
  2. Schumacher B, Hanazawa M, Lee MH, Nayak S, Volkmann K, Hofmann ER, Hengartner M, Schedl T, Gartner A; ''Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis.''; Cell, 2005 PubMed Europe PMC
  3. Gartner A, Boag PR, Blackwell TK; ''Germline survival and apoptosis.''; WormBook, 2008 PubMed Europe PMC
  4. Hofmann ER, Milstein S, Boulton SJ, Ye M, Hofmann JJ, Stergiou L, Gartner A, Vidal M, Hengartner MO; ''Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.''; Curr Biol, 2002 PubMed Europe PMC
  5. Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE, Lu X; ''iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.''; Nat Genet, 2003 PubMed Europe PMC
  6. Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, Conradt B, Shaham S; ''C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage.''; Cell Death Differ, 2005 PubMed Europe PMC
  7. Schumacher B, Hofmann K, Boulton S, Gartner A; ''The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis.''; Curr Biol, 2001 PubMed Europe PMC
  8. Quevedo C, Kaplan DR, Derry WB; ''AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans.''; Curr Biol, 2007 PubMed Europe PMC
  9. Deng X, Hofmann ER, Villanueva A, Hobert O, Capodieci P, Veach DR, Yin X, Campodonico L, Glekas A, Cordon-Cardo C, Clarkson B, Bornmann WG, Fuks Z, Hengartner MO, Kolesnick R; ''Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation.''; Nat Genet, 2004 PubMed Europe PMC
  10. Derry WB, Putzke AP, Rothman JH; ''Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.''; Science, 2001 PubMed Europe PMC
  11. Gartner A, Milstein S, Ahmed S, Hodgkin J, Hengartner MO; ''A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans.''; Mol Cell, 2000 PubMed Europe PMC
  12. Ahmed S, Alpi A, Hengartner MO, Gartner A; ''C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein.''; Curr Biol, 2001 PubMed Europe PMC


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68478view20:43, 5 July 2013MaintBotUpdated to 2013 gpml schema
67605view11:32, 26 June 2013DdiglesOntology Term : 'apoptotic cell death pathway' added !
40631view19:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
32410view17:05, 15 August 2009MaintBotFixed text labels
32066view13:35, 14 August 2009MaintBotFixed group labels
29816view22:47, 2 June 2009Khansperschanges gene symbols to IDs
21447view11:31, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:Programmed Cell Death]] moved to [[Pathway:WP367]]: Moved to stable identifier
19607view11:43, 9 October 2008MartijnVanIerselConnected lines to boxes
19605view11:41, 9 October 2008MartijnVanIerselpax genes, influence cell death in germline according to wormbook
19603view11:39, 9 October 2008MartijnVanIerselPeriodical save, work in progress
19140view10:59, 19 September 2008MartijnVanIerselModified categories
17683view05:07, 26 July 2008MartijnVanIerseladded a few missing wormbase links
17680view20:28, 25 July 2008WBDerryPeriodical save, work in progress
17678view20:18, 25 July 2008WBDerryPeriodical save, work in progress
17676view20:07, 25 July 2008WBDerryPeriodical save, work in progress
17674view19:57, 25 July 2008WBDerryPeriodical save, work in progress
17423view16:24, 22 July 2008WBDerryadded new genes
16666view20:46, 25 June 2008MartijnVanIerselModified description
16663view20:42, 25 June 2008MartijnVanIerselNew pathway

External references


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NameTypeDatabase referenceComment
abl-1GeneProductM79.1 (WormBase)
akt-1GeneProductC12D8.10 (WormBase)
ape-1GeneProductF46F3.4 (WormBase)
ced-13GeneProductR09F10.9 (WormBase)
ced-3GeneProductC48D1.2 (WormBase)
ced-4GeneProductC35D10.9 (WormBase)
ced-9GeneProductT07C4.8 (WormBase)
cep-1GeneProductF52B5.5 (WormBase)
clk-2GeneProductC07H6.6 (WormBase)
egl-1GeneProductF23B12.9 (WormBase)
egl-38GeneProductC04G2.7 (WormBase)
fsn-1GeneProductC26E6.5 (WormBase)
gld-1GeneProductT23G11.3 (WormBase)
gld-3GeneProductT07F8.3 (WormBase)
hpr-9GeneProductY39A1A.23 (WormBase)
hus-1GeneProductH26D21.1 (WormBase)
mrt-2GeneProductY41C4A.14 (WormBase)
pax-2GeneProductK06B9.5 (WormBase)

Annotated Interactions

No annotated interactions

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