Humoral Immune Response to Fungal and Bacterial Pathogens (Drosophila melanogaster)

From WikiPathways

Jump to: navigation, search
1PlasmatocyteThiolester ProteinsFungal B-1-3-glucansFat Body CellProteolytic cascadeLysine type PPGFungal and Bacterial Virulence FactorsDap Type PPGHemolymphJNK Signalingupd3PGRP-SApllPGRP-SDDiap2Myd88imdspztubTak1keyGNBP3ird5GNBP1TlJakFaddSPEpshimdRelDreddDiptericinTab2PGRP-LCDomelessPPStatStatStatStatStatNucleusDifDorsalcactDifDorsalcactDifPDorsalRelPRelDrosomycinAntimicrobial proteins


Description

Pathways regulating Drosophila's humoral response to bacterial and fungal pathogens. Pathogens such as fungal B-1-3-glucans and virulence factors illicit signalling pathways through receptors on body fat cells of Drosophila Melanogaster (Protein Toll, PGRP-LC, and Domeless). The activation of receptors initiates pathways that increase transcription of antimicrobial agents and thioester proteins. This pathway is based on figure 1 from Igboin et al.

Quality Tags

Ontology Terms

 

Bibliography

  1. Igboin CO, Griffen AL, Leys EJ; ''The Drosophila melanogaster host model.''; J Oral Microbiol, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
90080view05:03, 13 October 2016Khanspersoverhaul
90079view23:52, 12 October 2016KhanspersModified title
88668view15:31, 12 August 2016JmeliusOntology Term : 'immune response pathway' added !
88667view15:31, 12 August 2016JmeliusOntology Term : 'PW:0000004' removed !
88666view15:31, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
85929view18:26, 21 June 2016AAR&CoModified description
85823view19:22, 15 June 2016AAR&CoModified description
85822view18:57, 15 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Diap2GeneProductFBgn0015247 (Ensembl)
DifGeneProductFBgn0011274 (Ensembl)
DiptericinProteinP24492 (Uniprot-TrEMBL)
DomelessGeneProductFBgn0043903 (Ensembl)
DorsalProteinC7LA93 (Uniprot-TrEMBL) Dorsal Not Specified
DreddGeneProductFBgn0020381 (Ensembl)
DrosomycinProteinP41964 (Uniprot-TrEMBL)
FaddGeneProductFBgn0038928 (Ensembl)
GNBP1GeneProductFBgn0040323 (Ensembl)
GNBP3GeneProductFBgn0040321 (Ensembl)
JNK SignalingPathway
JakGeneProductFBgn0004864 (Ensembl)
Myd88GeneProductFBgn0033402 (Ensembl)
PGRP-LCGeneProductFBgn0035976 (Ensembl)
PGRP-SAGeneProductFBgn0030310 (Ensembl)
PGRP-SDGeneProductFBgn0035806 (Ensembl)
RelGeneProductFBgn0014018 (Ensembl)
SPEGeneProductFBgn0039102 (Ensembl)
StatGeneProductFBgn0016917 (Ensembl)
Tab2GeneProductFBgn0086358 (Ensembl)
Tak1GeneProductFBgn0026323 (Ensembl)
TlGeneProductFBgn0262473 (Ensembl)
cactGeneProductFBgn0000250 (Ensembl)
imdGeneProductFBgn0013983 (Ensembl)
ird5GeneProductFBgn0024222 (Ensembl)
keyGeneProductFBgn0041205 (Ensembl)
pllGeneProductFBgn0010441 (Ensembl)
pshGeneProductFBgn0030926 (Ensembl)
spzGeneProductFBgn0003495 (Ensembl)
tubGeneProductFBgn0003882 (Ensembl)
upd3GeneProductFBgn0053542 (Ensembl)

Annotated Interactions

No annotated interactions

Personal tools