Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex (Homo sapiens)

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1Key HSC Transcription FactorsDownregulationPhysiological AffectsGABP Complex AutoregulationLegendHypothetical InteractionsDNMT3BEP300PTENHSC SurvivalChromatin Remodeling and Epigenetic ModificationsGZMBZFXFoxo3aBCL2L1MCL1DNMT3AFLT3SMARCA4ATMHSC DifferentiationBCL2HSC Self RenewalETV6DNMT1GABPAGABPBHSC QuiescenceHSC AgingSMAD4TERF2CREBBP


Description

GABP alpha/beta complex mediates the maintenance of hematopoietic stem cells (HSCs) through control of proteins necessary for epigenetic modification and transcription regulation. The activation of key transcription factors and proteins required for HSC survival, self renewal, quiescence, differentiation, and aging is controlled by the GABP alpha/beta complex. This complex also down-regulates GZMB, protein important for inhibiting HSC survival. This pathway is based on figure 7 from Yu et al.

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Ontology Terms

 

Bibliography

  1. Yu S, Cui K, Jothi R, Zhao DM, Jing X, Zhao K, Xue HH; ''GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.''; Blood, 2011 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
89276view06:49, 29 August 2016Khansperslayout, added auto-regulatory loop
89067view08:39, 19 August 2016FehrhartFixed unconnected line
88493view22:44, 10 August 2016AAR&CoSpecify description
88491view22:41, 10 August 2016AAR&CoFixed Legend
88490view22:40, 10 August 2016AAR&CoFixed Legend
88486view22:28, 10 August 2016AAR&CoOntology Term : 'DNA modification pathway' added !
88485view22:25, 10 August 2016AAR&CoOntology Term : 'hematopoietic stem cell' added !
88484view22:24, 10 August 2016AAR&CoFixed Labels and interactions
88481view22:16, 10 August 2016AAR&CoPeriodical Save
88479view22:08, 10 August 2016AAR&CoPeriodical save, work in progress
87198view11:46, 19 July 2016EgonwChanged the species to human, as all genes had human IDs.
85925view18:17, 21 June 2016AAR&CoFixed unconnected lines
85924view18:15, 21 June 2016AAR&CoModified description
85802view23:39, 14 June 2016AAR&CoModified description
85797view22:12, 14 June 2016AAR&CoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATMGeneProductENSG00000149311 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
Chromatin Remodeling and Epigenetic ModificationsPathwayWP3362 (WikiPathways)
DNMT1GeneProductENSG00000130816 (Ensembl)
DNMT3AGeneProductENSG00000119772 (Ensembl)
DNMT3BGeneProductENSG00000088305 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
ETV6GeneProductENSG00000139083 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
Foxo3aProteinO43524 (Uniprot-TrEMBL)
GABPAGeneProductENSG00000154727 (Ensembl)
GABPBGeneProductENSG00000104064 (Ensembl) GABPB Not Specified
GZMBGeneProductENSG00000100453 (Ensembl)
HSC AgingPathwaymap04213 (KEGG Pathway) Identifier Not Found
HSC DifferentiationPathwayWP2849 (WikiPathways)
HSC QuiescencePathwayIdentifier Not Found
HSC Self RenewalPathwaymap04550 (KEGG Pathway)
HSC SurvivalPathwaymap04210 (KEGG Pathway)
MCL1GeneProductENSG00000143384 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SMARCA4GeneProductENSG00000127616 (Ensembl)
TERF2GeneProductENSG00000132604 (Ensembl)
ZFXGeneProductENSG00000005889 (Ensembl)

Annotated Interactions

No annotated interactions

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