Novel Jun-Dmp1 Pathway (Mus musculus)

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1MitogenAP-1Growth Arrest or ApoptosisDmp1Map2k1JunKrasp53Ink4aMycCcnd1Raf1ArfEts1Mapk1E2f1Mdm2Ets2JunbCdk4Rb1S PhaseEts2Ets1RrasNrasHrasArafBrafMap2k2Mapk3JunFosAP-1JunFos


Ras-Raf-MEK-ERK pathway interacting with Arf/Mdm2/p53 cell cycle pathway to regulate cell growth and proliferation. The signalling of a mitogen acts through the Ras-Raf-MEK-ERK pathway to inhibit the Rb protein and allow Myc and E2fs to continue into S phase and inhibits the Arf/Mdm2/p53 pathway leading to growth arrest or apoptosis. The Ras-Raf-MEK-ERK pathway also directly acts on the Arf/Mdm2/p53 pathway with Dmp1 to prevent tumor formation by activating Arf. Arf inhibits Mdm2 allowing p53 to lead the cell to growth arrest or apoptosis. This pathway is based on figure 7 from Sreeramaneni et al.

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Ontology Terms



  1. Sreeramaneni R, Chaudhry A, McMahon M, Sherr CJ, Inoue K; ''Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia


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90077view23:30, 12 October 2016KhanspersModified title
90076view23:30, 12 October 2016Khanspersdefine AP-1 transcription factor
90071view20:02, 11 October 2016KhanspersModified title
90070view20:01, 11 October 2016KhanspersExpanded Ras-Raf-MEK cascade, cleaned up
89114view19:03, 22 August 2016AAR&CoChanged data node
89113view19:01, 22 August 2016AAR&CoChanged data node
88469view23:19, 9 August 2016AAR&CoOntology Term : 'cell cycle pathway, mitotic' added !
88468view23:18, 9 August 2016AAR&CoAdded New Data Nodes
88467view23:15, 9 August 2016AAR&CoEdited Interactions and Labels
87629view08:54, 25 July 2016LindarieswijkOntology Term : 'Ras superfamily mediated signaling pathway' added !
87402view11:05, 22 July 2016MaintBotadded missing graphids
85921view18:10, 21 June 2016AAR&CoModified description
85920view18:09, 21 June 2016AAR&CoAdded Citation
85782view21:53, 12 June 2016AAR&CoModified description
85781view21:50, 12 June 2016AAR&CoEdit interaction
85780view21:36, 12 June 2016AAR&CoUnconnected Lines Fixed
85779view20:10, 12 June 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
ArafGeneProductENSMUSG00000001127 (Ensembl)
ArfGeneProductENSMUSG00000048076 (Ensembl) Arf Not Specified
BrafGeneProductENSMUSG00000002413 (Ensembl)
Ccnd1GeneProductENSMUSG00000070348 (Ensembl)
Cdk4GeneProductENSMUSG00000006728 (Ensembl)
Dmp1GeneProductENSMUSG00000029307 (Ensembl)
E2f1GeneProductENSMUSG00000027490 (Ensembl)
Ets1GeneProductENSMUSG00000032035 (Ensembl)
Ets2GeneProductENSMUSG00000022895 (Ensembl)
FosGeneProductENSMUSG00000021250 (Ensembl)
Growth Arrest or ApoptosisPathwayWP1254 (WikiPathways)
HrasGeneProductENSMUSG00000025499 (Ensembl) Ras Not Specified
Ink4aGeneProductENSMUSG00000044303 (Ensembl)
JunGeneProductENSMUSG00000052684 (Ensembl)
JunbGeneProductENSMUSG00000052837 (Ensembl)
KrasGeneProductENSMUSG00000030265 (Ensembl) Ras Not Specified
Map2k1GeneProductENSMUSG00000004936 (Ensembl)
Map2k2GeneProductENSMUSG00000035027 (Ensembl)
Mapk1GeneProductENSMUSG00000063358 (Ensembl)
Mapk3GeneProductENSMUSG00000063065 (Ensembl)
Mdm2GeneProductENSMUSG00000020184 (Ensembl)
MycGeneProductENSMUSG00000022346 (Ensembl)
NrasGeneProductENSMUSG00000027852 (Ensembl) Ras Not Specified
Raf1GeneProductENSMUSG00000000441 (Ensembl)
Rb1GeneProductENSMUSG00000022105 (Ensembl)
RrasGeneProductENSMUSG00000038387 (Ensembl) Ras Not Specified
S PhasePathwayWP413 (WikiPathways)
p53GeneProductENSMUSG00000059552 (Ensembl)

Annotated Interactions

No annotated interactions

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