Acetate mediated promotion of metabolic syndrome (Rattus norvegicus)

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1PlasmaMicrobial cellinsulinparasympatheticnervous systemfatty acidacetategastrinHigh fat dietglucosefatty acidacetate


Acetates produced by gut microbes stimulates the parasympathetic nervous system which causes in an increase in the release of the gastrin hormone which triggers insulin release from beta-cells. Prolonged exposure to high acetate levels promote a state of metabolic syndrome.

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Ontology Terms



  1. Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI; ''Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome.''; Nature, 2016 PubMed Europe PMC


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93052view12:27, 27 July 2017DeSlChanged glucose ID to D-glucose ID.
89051view22:46, 18 August 2016AriuttaOntology Term : 'disease pathway' added !
85964view23:32, 21 June 2016KhanspersOntology Term : 'parasympathetic neuron' added !
85963view23:32, 21 June 2016KhanspersOntology Term : 'B cell' added !
85962view23:30, 21 June 2016KhanspersOntology Term : 'acquired metabolic disease' added !
85763view14:24, 11 June 2016EgonwNow has the rat IDs.
85762view14:15, 11 June 2016EgonwModified description
85761view14:13, 11 June 2016EgonwModified title
85760view14:12, 11 June 2016EgonwNew pathway

External references


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NameTypeDatabase referenceComment
High fat diet
acetateMetaboliteCHEBI:30089 (ChEBI)
fatty acidMetaboliteCHEBI:35366 (ChEBI)
gastrinProteinP04563 (Uniprot-TrEMBL)
glucoseMetaboliteCHEBI:17634 (ChEBI)
insulinProteinP01323 (Uniprot-TrEMBL)
parasympathetic nervous system

Annotated Interactions

No annotated interactions

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