Crystal Toxin Triggered Necrosis Pathway (Caenorhabditis elegans)

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1Increase in intracellular [Ca2+]Cytosolic AcidificationLysosomal RuptureCell NecrosisASP-1Cysteine ProteaseCry6AaCalpain TRA-3ASP-4Killer Cathepsin ProteaseASP-3ATPITR-1 ChannelVHA-12H+Ca2+


This pathway is modeled on a description provided in Zhang et al. under the title "A deficiency in the necrosis pathway confers tolerance to Cry6Aa". Cry6Aa binds to the calcium channel ITR-1 and increases intracellular Ca2+ levels. Ca2+ binds to and activates Calpain TRA-3 which promotes cysteine protease activity. Cysteine Protease activates VHA-12 that uses ATP to increase pH of the cytosol. The increase in H+ concentration signals to the ASP-1/ASP-3/ASP-4 complex which leads to activation of killer cathepsin protease and leads to cell necrosis.

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Ontology Terms



  1. Zhang F, Peng D, Cheng C, Zhou W, Ju S, Wan D, Yu Z, Shi J, Deng Y, Wang F, Ye X, Hu Z, Lin J, Ruan L, Sun M; ''Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1).''; PLoS Pathog, 2016 PubMed Europe PMC Scholia


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106027view11:55, 16 August 2019MaintBotHMDB identifier normalization
89743view23:47, 29 September 2016KhanspersModified title
89742view23:47, 29 September 2016KhanspersModified title
88453view15:41, 8 August 2016AAR&CoModified Datanode
88452view15:37, 8 August 2016AAR&CoModified Datanode
88201view12:59, 31 July 2016AAR&CoAdded Datanode
88199view12:44, 31 July 2016AAR&CoNew Datanode
88198view12:41, 31 July 2016AAR&CoWork in Progress
88197view12:36, 31 July 2016AAR&CoWork in Progress
88196view12:35, 31 July 2016AAR&CoWork in Progress
88194view12:31, 31 July 2016AAR&CoAdded New Datanode
87901view12:54, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
87469view14:24, 22 July 2016AAR&CoFixed Data Nodes
87276view16:39, 20 July 2016AAR&CoOntology Term : 'gas gangrene' added !
87272view16:23, 20 July 2016AAR&CoFixed Asthetics
87271view16:22, 20 July 2016AAR&CoFixed Interactions
87270view16:20, 20 July 2016AAR&CoModified description
87269view16:12, 20 July 2016AAR&CoFixed Unconnected Line and Labels
87267view16:08, 20 July 2016AAR&CoOntology Term : 'necrosis pathway' added !
85620view12:51, 3 June 2016AAR&CoQuick edit to datanode annotation or property
85604view16:01, 2 June 2016AAR&CoAdded Citation
85603view15:59, 2 June 2016AAR&CoFinishing Pathway
85602view15:51, 2 June 2016AAR&CoPeriodical save, work in progress
85601view15:40, 2 June 2016AAR&CoPeriodical save, work in progress
85600view15:30, 2 June 2016AAR&CoPeriodical save, work in progress
85599view15:19, 2 June 2016AAR&CoFurther Work
85598view15:12, 2 June 2016AAR&CoPeriodical save, work in progress
85595view22:17, 1 June 2016AAR&CoPeriodical save, work in progress
85594view22:05, 1 June 2016AAR&CoSpecify description
85593view22:03, 1 June 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
ASP-1GeneProductWBGene00000214 (Ensembl)
ASP-3GeneProductWBGene00000216 (Ensembl)
ASP-4GeneProductWBGene00000217 (Ensembl)
ATPMetaboliteHMDB0001532 (HMDB)
Ca2+Metabolite271 (PubChem-compound)
Calpain TRA-3GeneProductWBGene00006606 (Ensembl)
Cry6AaGeneProductQ45757 (Uniprot-TrEMBL)
Cysteine ProteaseGeneProductWBGene00000543 (Ensembl)
H+Metabolite1038 (PubChem-compound)
ITR-1 ChannelGeneProductWBGene00002173 (Ensembl)
Killer Cathepsin ProteaseGeneProductWBGene00000783 (Ensembl)
VHA-12GeneProductWBGene00006921 (Ensembl)

Annotated Interactions

No annotated interactions

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