SK UDPglcnac (Escherichia coli)

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GlmUglmU213nagApgiglmMglmSglpKmurGnagZNagKExtracellular spaceN-acetylglucosamine-1-PGlycolysisompFptsGN-AcetylglucosamineN-acetylglucosamineglpFAcetyl-CoAElectron transport chainmurAN-acetylglucosamine-6PGluconeogenesisNagPKrebs cycleampGGlycerol-3PftsWnagEGlcNAc-1PUDP-N-acetylglucosamineGlucosamine-1PpeptidoglycanCOSGlcNAcNodCGlucosamine-6PN-acetylglucosamineglucoseGlycerolGlycerolGlycerolGlucoseGlucose-6PFructose-6POmpFUTPPeriplasmCytoplasmnagBGlutamineATPATPATPATPAcetatemurJNagKUTPUDP-GlcNActrGlmU


Description

"Escherichia coli (E. Coli) contains a specific acyltransferase that derivatizes UDP-GlcNAc, which is the first obligatory reaction in the formation of lipid A (1-3), a unique glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane of gramnegative bacteria." (rephrased from Anderson et al (1993)[1] ).

Quality Tags

Ontology Terms

 

Bibliography

  1. Xiaolong Liu, Nils Y. Meiresonne, Ahmed Bouhss, Tanneke den Blaauwen; ''FtsW activity and lipid II synthesis are required for recruitment of MurJ to midcell during cell division in Escherichia coli''; Molecular microbiology 109.6: 855-884, 2018
  2. Anderson MS, Bull HG, Galloway SM, Kelly TM, Mohan S, Radika K, Raetz CR; ''UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable.''; J Biol Chem, 1993 PubMed Europe PMC
  3. Xiaolong Liu, Nils Y. Meiresonne, Ahmed Bouhss, Tanneke den Blaauwen; ''FtsW activity and lipid II synthesis are required for recruitment of MurJ to midcell during cell division in Escherichia coli''; Molecular microbiology 109.6: 855-884, 2018

History

View all...
CompareRevisionActionTimeUserComment
107104view14:18, 17 September 2019MaintBotChEBI identifier normalization
106104view12:01, 16 August 2019MaintBotHMDB identifier normalization
102505view13:37, 30 December 2018DeSlAdded info from WP3643 to this PW.
102504view13:19, 30 December 2018DeSlAdded more IDs.
102470view06:34, 24 December 2018EgonwReplaced secondary ChEBI IDs with primary IDs.
102439view13:32, 23 December 2018DeSlOntology Term : 'glucose transport pathway' added !
102438view13:32, 23 December 2018DeSlOntology Term : 'glucose metabolism disease' added !
102437view13:31, 23 December 2018DeSlOntology Term : 'PW:0001328' removed !
102436view13:31, 23 December 2018DeSlOntology Term : 'peptidoglycan biosynthetic pathway' added !
102435view13:28, 23 December 2018DeSlModified description
102434view13:27, 23 December 2018DeSlModified description
102433view13:25, 23 December 2018DeSlAdded lit ref
102432view13:21, 23 December 2018DeSl
102431view13:20, 23 December 2018DeSlAdded lit ref for specific interaction
102430view13:17, 23 December 2018DeSlAnnotated enzymes; added murJ and ftsW as separate nodes
102429view13:07, 23 December 2018DeSlAdded more metabolite IDs
102411view08:15, 23 December 2018EgonwReplaced secondary ChEBI IDs with primary IDs.
102406view19:02, 22 December 2018DeSlSTarted annotating nodes
102402view14:35, 22 December 2018DeSlChanged textlabels to protein nodes, and connected proteins to conversion arrow
102401view14:29, 22 December 2018DeSlChanged more lines to MIM type
102400view14:27, 22 December 2018DeSlChanged arrows to Conversion/Binding where appropriate
97049view15:10, 26 April 2018EgonwConnected two more lines (HT to Tina for the trick)
97041view15:02, 26 April 2018EgonwFixed some unconnected lines.
87672view08:55, 25 July 2016LindarieswijkOntology Term : 'uridine diphosphate glucose metabolic pathway' added !
85508view21:38, 23 May 2016SkrekelsSpecify description
85507view21:37, 23 May 2016SkrekelsSpecify description
85506view21:29, 23 May 2016SkrekelsSpecify description
85505view21:26, 23 May 2016SkrekelsPeriodical save, work in progress
85504view21:22, 23 May 2016SkrekelsSpecify description
85503view21:16, 23 May 2016SkrekelsPeriodical save, work in progress
85502view21:11, 23 May 2016SkrekelsSpecify description
85501view21:10, 23 May 2016SkrekelsSpecify description
85500view21:08, 23 May 2016SkrekelsSpecify description
85499view21:05, 23 May 2016SkrekelsSpecify description
85498view20:59, 23 May 2016SkrekelsSpecify description
85497view20:55, 23 May 2016SkrekelsPeriodical save, work in progress
85495view20:47, 23 May 2016SkrekelsSpecify description
85494view20:45, 23 May 2016SkrekelsPeriodical save, work in progress
85493view20:40, 23 May 2016SkrekelsSpecify description
85492view20:35, 23 May 2016SkrekelsPeriodical save, work in progress
85491view20:33, 23 May 2016SkrekelsSpecify description
85490view20:28, 23 May 2016SkrekelsSpecify description
85488view20:01, 23 May 2016SkrekelsSpecify description
85487view19:32, 23 May 2016SkrekelsPeriodical save, work in progress
85486view19:16, 23 May 2016SkrekelsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetaboliteCHEBI:15422 (ChEBI)
AcetateMetaboliteQ212527 (Wikidata)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
COSMetabolite
Electron transport chainPathway
Fructose-6PMetaboliteCHEBI:15946 (ChEBI)
GlcNAc-1PMetaboliteCHEBI:16446 (ChEBI)
GlcNAcMetaboliteCHEBI:506227 (ChEBI)
GlmUProteinb3730 (Ensembl)
GluconeogenesisPathway
Glucosamine-1PMetaboliteHMDB0001109 (HMDB)
Glucosamine-6PMetaboliteQ55168356 (Wikidata)
Glucose-6PMetaboliteQ32778969 (Wikidata)
GlucoseMetaboliteCHEBI:17234 (ChEBI)
GlutamineMetaboliteQ181619 (Wikidata)
Glycerol-3PMetaboliteCHEBI:26706 (ChEBI) Added CheBI-group as ID
GlycerolMetaboliteCHEBI:17754 (ChEBI)
GlycolysisPathway
Krebs cyclePathway
N-AcetylglucosamineMetaboliteCHEBI:506227 (ChEBI)
N-acetylglucosamine-1-PMetaboliteCHEBI:16446 (ChEBI)
N-acetylglucosamine-6PMetaboliteQ27098230 (Wikidata)
N-acetylglucosamineMetaboliteQ27225758 (Wikidata)
NagKProteinP75959 (Uniprot-TrEMBL)
NagKProtein
NagPProtein
NodCProtein
OmpFProteinb0929 (Ensembl)
UDP-GlcNAcMetaboliteCHEBI:16264 (ChEBI)
UDP-N-acetylglucosamineMetaboliteCHEBI:16264 (ChEBI)
UTPMetaboliteCHEBI:46398 (ChEBI)
ampGGeneProductb0433 (Ensembl)
ftsWGeneProductb0089 (Ensembl)
glmMGeneProductb3176 (Ensembl)
glmSGeneProductb3729 (Ensembl)
glmUGeneProductb3730 (Ensembl)
glpFGeneProductb3927 (Ensembl)
glpKGeneProductb3926 (Ensembl)
glucoseMetaboliteCHEBI:17234 (ChEBI)
murAGeneProductb3189 (Ensembl)
murGGeneProductb0090 (Ensembl)
murJGeneProductb1069 (Ensembl)
nagAGeneProductb0677 (Ensembl)
nagBGeneProductb0678 (Ensembl)
nagEGeneProductb0679 (Ensembl)
nagZGeneProductb1107 (Ensembl)
ompFGeneProductb0929 (Ensembl)
peptidoglycanMetaboliteCHEBI:8005 (ChEBI)
pgiGeneProductb4025 (Ensembl)
ptsGGeneProductb1101 (Ensembl)
trGlmUProtein

Annotated Interactions

No annotated interactions

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