Turbo design of glycolysis (Saccharomyces cerevisiae)

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1HMPATPADPGlcFru 1,6 P2Tre 6 P


Description

Many catabolic pathways begin with an ATP-requiring activation step, after which further metabolism yields a surplus of ATP. Such a 'turbo' principle is useful but also contains an inherent risk. This is illustrated by a detailed kinetic analysis of glycolysis in a Saccharomyces cerevisiae mutant.

The model has been converted to GPML using the PathSBML plugin from PathVIsio, importing the model BIOMD0000000253 from the BioModels Database directly. The layout has been improved manually.

Quality Tags

Ontology Terms

 

Bibliography

  1. Teusink B, Walsh MC, van Dam K, Westerhoff HV; ''The danger of metabolic pathways with turbo design.''; Trends Biochem Sci, 1998 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
107022view13:47, 17 September 2019MaintBotHMDB identifier normalization
86057view23:18, 28 June 2016KhanspersOntology Term : 'glycolysis pathway' added !
85138view02:01, 19 April 2016AnweshaModified description
85133view01:51, 19 April 2016AnweshaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Fru 1,6 P2MetaboliteHMDB0001058 (HMDB)
GlcMetaboliteCHEBI:17925 (ChEBI)
HMPMetaboliteCHEBI:17665 (ChEBI)
Tre 6 PMetaboliteCHEBI:18283 (ChEBI)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ADP13068 (Rhea)
ADPlower (WikiPathways)
ATP13068 (Rhea)
ATPR00756 (KEGG Reaction)
ATPR02848 (KEGG Reaction)
Fru 1,6 P2R00756 (KEGG Reaction)
Fru 1,6 P2lower (WikiPathways)
GlcR02848 (KEGG Reaction)
HMPR00756 (KEGG Reaction)
HMPR02848 (KEGG Reaction)
Tre 6 PR02848 (KEGG Reaction)
lower (WikiPathways)
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