Insulin signalling in human adipocytes (normal condition) (Homo sapiens)

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1IRS1mTORC2INSRAS160INSRS6KpGLUT4mAS160pINSRIRS1p307mTORC2ainsulinPKB308pIRS1pINSRS6mTORC1aXINSRmTORC1PKB308p473pS6KIRS1307XS6pGLUT4PPKBPKB473pPinsulin


Description

The paper describes insulin signalling in human adipocytes under normal and diabetic states using mathematical models based on experimental data. This model corresponds to insulin signalling under normal condition. Insulin signalling under diabetic condition is represented in WP3635.

The model has been converted to GPML using the PathSBML plugin from PathVIsio, importing the model BIOMD0000000448 from the BioModels Database directly. The layout has been improved manually.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Brännmark C, Nyman E, Fagerholm S, Bergenholm L, Ekstrand EM, Cedersund G, Strålfors P; ''Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.''; J Biol Chem, 2013 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106618view20:46, 12 September 2019KhanspersModified description
105627view05:02, 10 August 2019KhanspersModified description
104380view02:49, 23 May 2019RyanmillerUpdated interaction that had used the wrong Database Name. Changed name to KeGG Compound.
102467view05:59, 24 December 2018EgonwFixed data sources.
102466view05:57, 24 December 2018EgonwFixed a data source.
97676view13:08, 1 June 2018AMTanOntology Term : 'fat cell' added !
86060view23:22, 28 June 2016KhanspersOntology Term : 'insulin signaling pathway' added !
85136view01:56, 19 April 2016AnweshaModified description
85134view01:53, 19 April 2016AnweshaModified description
85131view01:45, 19 April 2016AnweshaModified title
85130view01:36, 19 April 2016AnweshaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AS160ProteinO60343 (Uniprot-TrEMBL)
AS160pGeneProductPATO:0002220 (pato)
GLUT4ProteinP14672 (Uniprot-TrEMBL)
GLUT4mProteinP14672 (Uniprot-TrEMBL)
INSRProteinP06213 (Uniprot-TrEMBL) Tyrosine phosphorylated
IRS1307ProteinP35568 (Uniprot-TrEMBL)
IRS1ProteinP35568 (Uniprot-TrEMBL)
IRS1p307ProteinP35568 (Uniprot-TrEMBL)
IRS1pProteinP35568 (Uniprot-TrEMBL)
PMetaboliteCHEBI:28659 (ChEBI)
PKB308p473pProteinP31751 (Uniprot-TrEMBL)
PKB308pProteinP31751 (Uniprot-TrEMBL)
PKB473pProteinP31751 (Uniprot-TrEMBL)
PKBProteinP31751 (Uniprot-TrEMBL)
S6KProteinP23443 (Uniprot-TrEMBL)
S6KpProteinP23443 (Uniprot-TrEMBL)
S6ProteinP62753 (Uniprot-TrEMBL)
S6pProteinP62753 (Uniprot-TrEMBL)
XMetaboliteC00562 (KEGG Compound) active feedback protein
XMetaboliteCHEBI:36080 (ChEBI) inactive feedback protein
insulinMetaboliteCHEBI:5931 (ChEBI)
mTORC1ProteinP42345 (Uniprot-TrEMBL)
mTORC1aProteinP42345 (Uniprot-TrEMBL)
mTORC2ProteinP42345 (Uniprot-TrEMBL)
mTORC2aProteinP42345 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
AS160O60343 (Uniprot-TrEMBL)
AS160pPATO:0002220 (pato)
C00562 (KEGG Compound)
GLUT4P14672 (Uniprot-TrEMBL)
GLUT4mP14672 (Uniprot-TrEMBL)
INSRP06213 (Uniprot-TrEMBL)
IRS1307P35568 (Uniprot-TrEMBL)
IRS1P35568 (Uniprot-TrEMBL)
IRS1p307P35568 (Uniprot-TrEMBL)
IRS1pP35568 (Uniprot-TrEMBL)
P06213 (Uniprot-TrEMBL)
PKB308p473pP31751 (Uniprot-TrEMBL)
PKB308pP31751 (Uniprot-TrEMBL)
PKB473pP31751 (Uniprot-TrEMBL)
PKBP31751 (Uniprot-TrEMBL)
R02584 (KEGG Reaction)
S6KP23443 (Uniprot-TrEMBL)
S6KpP23443 (Uniprot-TrEMBL)
S6P62753 (Uniprot-TrEMBL)
S6pP62753 (Uniprot-TrEMBL)
XCHEBI:36080 (ChEBI)
mTORC1P42345 (Uniprot-TrEMBL)
mTORC1aP42345 (Uniprot-TrEMBL)
mTORC2P42345 (Uniprot-TrEMBL)
mTORC2aP42345 (Uniprot-TrEMBL)
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