Crabtree effect (Saccharomyces cerevisiae)

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Description

Named after the English biochemist Herbert Grace Crabtree, the Crabtree effect describes the phenomenon whereby the yeast, Saccharomyces cerevisiae, produces ethanol (alcohol) in aerobic conditions and high external glucose concentrations rather than producing biomass via the tricarboxylic acid (TCA) cycle, the usual process occurring aerobically in most yeasts e.g. Kluyveromyces spp. This phenomenon is observed in most species of the Saccharomyces, Schizosaccharomyces, Debaryomyces, Brettanomyces, Torulopsis, Nematospora, and Nadsonia genera. Increasing concentrations of glucose accelerates glycolysis (the breakdown of glucose) which results in the production of appreciable amounts of ATP through substrate-level phosphorylation. This reduces the need of oxidative phosphorylation done by the TCA cycle via the electron transport chain and therefore decreases oxygen consumption. The phenomenon is believed to have evolved as a competition mechanism (due to the antiseptic nature of ethanol) around the time when the first fruits on Earth fell from the trees. The crabtree effect works by repressing respiration by the fermentation pathway, dependent on the substrate. Description source: Wikipedia

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Bibliography

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History

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CompareRevisionActionTimeUserComment
95369view15:38, 10 December 2017Marvin M2Connected the last 2 unconnected lines. They were hidden underneath nodes.
95076view14:33, 11 November 2017EgonwAdded missing ID for acetate.
94919view05:27, 13 October 2017Khanspersannotated nodes
94918view05:12, 13 October 2017Khanspersconnected interactions
94917view05:03, 13 October 2017KhanspersModified description
93004view18:50, 21 July 2017KhanspersModified description
87205view14:06, 19 July 2016SusanOntology Term : 'energy metabolic pathway' added !
85080view12:15, 12 April 2016AldarodriguesPeriodical save, work in progress
85079view12:01, 12 April 2016AldarodriguesPeriodical save, work in progress
85078view11:51, 12 April 2016AldarodriguesPeriodical save, work in progress
85077view10:51, 12 April 2016AldarodriguesPeriodical save, work in progress
85031view07:20, 7 April 2016AldarodriguesCrabtree_3
85017view13:46, 5 April 2016Aldarodriguescrabtree_corrected
85016view11:02, 5 April 2016Aldarodriguescrabtree_without_title
85015view10:47, 5 April 2016AldarodriguesPeriodical save, work in progress
85014view10:36, 5 April 2016AldarodriguesPeriodical save, work in progress
85013view10:26, 5 April 2016AldarodriguesPeriodical save, work in progress
85012view10:16, 5 April 2016AldarodriguesPeriodical save, work in progress
85011view09:56, 5 April 2016AldarodriguesPeriodical save, work in progress
85010view09:46, 5 April 2016AldarodriguesPeriodical save, work in progress
85000view21:37, 4 April 2016Aldarodriguescrabtree_1
84999view21:31, 4 April 2016AldarodriguesPeriodical save, work in progress
84998view21:21, 4 April 2016AldarodriguesPeriodical save, work in progress
84997view21:11, 4 April 2016AldarodriguesPeriodical save, work in progress
84996view21:00, 4 April 2016AldarodriguesPeriodical save, work in progress
84995view20:50, 4 April 2016AldarodriguesPeriodical save, work in progress
84993view20:39, 4 April 2016AldarodriguesPeriodical save, work in progress
84990view20:29, 4 April 2016AldarodriguesNew pathway

External references

Datanodes

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NameTypeDatabase referenceComment
3-PhosphoglycerateMetaboliteCHEBI:17794 (ChEBI)
ADH1 Protein
AcetaldehydeMetaboliteHMDB00990 (HMDB)
AcetateMetaboliteCHEBI:30089 (ChEBI)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
Dihydroxyacetone phosphate MetaboliteHMDB01473 (HMDB)
EthanolMetaboliteHMDB00108 (HMDB)
Fructose 1,6-PhosphateMetaboliteHMDB01058 (HMDB)
Fructose 6-PhosphateMetaboliteHMDB00124 (HMDB)
FumarateMetaboliteCHEBI:18012 (ChEBI)
GDP1 Protein
GDP2Protein
Glucose 6-PhosphateMetaboliteHMDB01401 (HMDB)
GlucoseMetaboliteHMDB00122 (HMDB)
Glyceraldehyde 3-PhosphateMetaboliteHMDB01112 (HMDB)
Glycerol 3-PhosphateMetaboliteHMDB00126 (HMDB)
GlycerolMetaboliteHMDB00131 (HMDB)
GlyoxylateMetaboliteCHEBI:5509 (ChEBI)
L-malateMetaboliteCHEBI:15589 (ChEBI)
OxaloacetateMetaboliteCHEBI:30744 (ChEBI)
PDC2 Protein
PhosphoenolpyruvateMetaboliteCHEBI:8147 (ChEBI)
TPI1 Protein
alpha-ketoglutarateMetaboliteCHEBI:16810 (ChEBI)
isocitrateMetaboliteCHEBI:16087 (ChEBI)
pyruvateMetaboliteCHEBI:15361 (ChEBI)
succinateMetaboliteCHEBI:30031 (ChEBI)

Annotated Interactions

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