Photodynamic therapy-induced AP-1 survival signaling. (Homo sapiens)

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Photodynamic therapy may induce an acute stress response mediated by mitogen-activated protein kinase kinase kinase 5 (MAP3K5), its downstream MAPKs that target c-Jun N-terminal kinase (JNK, MAPK8) and p38MAPK, and the transcription factors of the activator protein 1 (AP-1) family.

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  1. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M; ''Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies.''; Cancer Metastasis Rev, 2015 PubMed Europe PMC Scholia
  2. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, Moerland PD, van Kampen AH, van Gulik TM, Heger M; ''Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.''; BMC Cancer, 2015 PubMed Europe PMC Scholia


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90923view02:44, 18 December 2016AlexanderPicoOntology Term : 'PW:0000263' removed !
88314view15:36, 1 August 2016FehrhartOntology Term : 'altered regulatory pathway' added !
88313view15:36, 1 August 2016FehrhartOntology Term : 'altered regulatory pathway' added !
86065view23:30, 28 June 2016KhanspersOntology Term : 'cancer' added !
84548view19:18, 1 March 2016MaintBotmore groups and connections
84542view19:04, 1 March 2016MaintBotConnected interactions
84530view20:02, 29 February 2016RuudweijerAdded reference
84503view07:42, 26 February 2016RuudweijerModified description
84502view07:38, 26 February 2016RuudweijerModified title
84457view18:09, 25 February 2016RuudweijerAdded literature reference
84446view08:30, 25 February 2016RuudweijerModified description
84445view08:30, 25 February 2016RuudweijerNew pathway

External references


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NameTypeDatabase referenceComment
ATF2GeneProduct1386 (Entrez Gene)
BAK1GeneProduct578 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BCL2L11GeneProduct10018 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
BCL3GeneProduct602 (Entrez Gene)
BIDGeneProduct637 (Entrez Gene)
BMFGeneProduct90427 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CFLARGeneProduct8837 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
FASGeneProduct355 (Entrez Gene)
FASLGGeneProduct356 (Entrez Gene)
FGF7GeneProduct2252 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
HBEGFGeneProduct1839 (Entrez Gene)
HSP90AA1GeneProduct3320 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
JUNBGeneProduct3726 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MCL1GeneProduct4170 (Entrez Gene)
MMP2GeneProduct4313 (Entrez Gene)
NFE2L2GeneProduct4780 (Entrez Gene)
PDGFRAGeneProduct5156 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TNFRSF1AGeneProduct7132 (Entrez Gene)
TNFSF10GeneProduct8743 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TRAF2GeneProduct7186 (Entrez Gene)
TRAF5GeneProduct7188 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)

Annotated Interactions

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